YRC Public Data Repository - Protein Structure Prediction

Protein:	HMX1
Organism:	Saccharomyces cerevisiae
Length:	317 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMX1.

Description	E-value	Query Range	Subject Range
HMX1 - ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxy... HMX1_YEAST - Heme-binding protein HMX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HMX1 PE=2 SV=3	4.0E-95	[1..317]	[1..317]
gi\|22297908, gi\|... - gi\|22297908\|ref\|NP_681155.1\| heme oxygenase 1 [Thermosynechococcus elongatus BP-1], gi\|22294086\|dbj\|...	2.0E-70	[14..284]	[2..234]
gi\|31415692 - gi\|31415692\|gb\|AAP45707.1\| heme oxygenase 1 [Expression vector pAT101]	1.0E-68	[14..284]	[25..256]
HO1_SYNY3 - Heme oxygenase 1 OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=pbsA1 PE=1 SV=1 gi\|7433265, gi\|5... - pir\|\|S74713 heme oxygenase (decyclizing) (EC 1.14.99.3) 1 - Synechocystis sp. (strain PCC 6803), gi... HO1_SYNY3 - Heme oxygenase 1 OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=pbsA1 PE=1 SV=1	2.0E-68	[14..284]	[1..232]
gi\|33864707, gi\|... - gi\|33864707\|ref\|NP_896266.1\| Heme oxygenase [Synechococcus sp. WH 8102], gi\|33632230\|emb\|CAE06686.1\|...	1.0E-67	[14..285]	[1..234]
gi\|56687204, gi\|... - gi\|56752245\|ref\|YP_172946.1\| heme oxygenase [Synechococcus elongatus PCC 6301], gi\|56687204\|dbj\|BAD8... gi\|45513325, gi\|... - gi\|81300667\|ref\|YP_400875.1\| Heme oxygenase (decyclizing) [Synechococcus elongatus PCC 7942], gi\|811...	7.0E-67	[14..284]	[1..232]
gi\|186681144, gi... - gi\|4105611\|gb\|AAD02479.1\| heme oxygenase; HO1 [Nostoc punctiforme], gi\|23124602\|ref\|ZP_00106581.1\| C...	8.0E-67	[14..284]	[1..233]
HMOX2_RAT - Heme oxygenase 2 OS=Rattus norvegicus GN=Hmox2 PE=1 SV=1	2.0E-66	[2..257]	[13..239]
HO1_NOSS1 - Heme oxygenase 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=pbsA1 PE=3 SV=1 gi\|25285771 - pir\|\|AC2043 heme oxygenase [imported] - Nostoc sp. (strain PCC 7120)	5.0E-66	[14..284]	[1..233]
gi\|2984776, gi\|6... - gi\|6754214\|ref\|NP_034573.1\| heme oxygenase (decycling) 2 [Mus musculus], gi\|2984776\|gb\|AAC82364.1\| h...	6.0E-66	[2..257]	[13..239]

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Predicted Domain #1

Region A:
Residues: [1-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSSNTIIP SPTDVGALAN RINFQTRDAH NKINTFMGIK MAIAMRHGFI YRQGILAYYY  60
   61 VFDAIEQEID RLLNDPVTEE ELQTSTILKQ FWLEDFRRST QIYKDLKLLY SNTFKSTESL 120
  121 NEFLATFQKP PLLQQFINNI HENIHKEPCT ILSYCHVLYL ALFAGGKLIR SNLYRRLGLF 180
  181 PNFEKLSQKE LVKKGTNFFT FSDLGPTEET RLKWEYKKNY ELATRTELTE AQKLQIISVA 240
  241 EGIFDWNFNI VAEIGELNRR ELMGKFSFKC ITYLYEEWMF NKDSATRRAL HTVMLLVLSI 300
  301 IAIWVLYFLV KSFLSIV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.522879
Match:	1n3uA_
Description:	Heme oxygenase-1 (HO-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
heme oxygenase (decyclizing) activity	6.01769064893884	bayes_pls_golite062009
phospholipase D activity	1.4947586862989	bayes_pls_golite062009
binding	1.17561038899526	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1.04224985135083	bayes_pls_golite062009
catalytic activity	0.476060647762462	bayes_pls_golite062009
protein binding	0.338386262372183	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: