Protein Overview: GCH1_ARATH

General Information:
Name(s) found:	GCH1_ARATH [Swiss-Prot]
Description(s) found: Found 13 descriptions. SHOW ALL	GTP cyclohydrolase 1 OS=Arabidopsis thaliana GN=GCH1 PE=1 SV=1 [Swiss-Prot]
Organism:	Arabidopsis thaliana
Length:	466 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA]
Biological Process:	tetrahydrofolate biosynthetic process [IEA] biosynthetic process [ISS]
Molecular Function:	GTP cyclohydrolase I activity [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGALDEGCLN LELDIGMKNG CIELAFEHQP ETLAIQDAVK LLLQGLHEDV NREGIKKTPF  60
   61 RVAKALREGT RGYKQKVKDY VQSALFPEAG LDEGVGQAGG VGGLVVVRDL DHYSYCESCL 120
  121 LPFHVKCHIG YVPSGQRVLG LSKFSRVTDV FAKRLQDPQR LADDICSALQ HWVKPAGVAV 180
  181 VLECSHIHFP SLDLDSLNLS SHRGFVKLLV SSGSGVFEDE SSNLWGEFQS FLMFKGVKTQ 240
  241 ALCRNGSSVK EWCPSVKSSS KLSPEVDPEM VSAVVSILKS LGEDPLRKEL IATPTRFLKW 300
  301 MLNFQRTNLE MKLNSFNPAK VNGEVKEKRL HCELNMPFWS MCEHHLLPFY GVVHIGYFCA 360
  361 EGSNPNPVGS SLMKAIVHFY GFKLQVQERM TRQIAETLSP LVGGDVIVVA EAGHTCMISR 420
  421 GIEKFGSSTA TIAVLGRFSS DNSARAMFLD KIHTTNALKT ESSSPF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..235]	FFAS03	8.45	Structure of GTP cyclohydrolase I from Thermus thermophilus HB8
2	View Details	[236..466]	PSI-BLAST	80.39794	GTP cyclohydrolase I

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
GTP cyclohydrolase I activity	4.58215881457764	bayes_pls_golite062009
cyclohydrolase activity	3.1225900680321	bayes_pls_golite062009
GTP cyclohydrolase activity	2.816522292063	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.34489533040902	bayes_pls_golite062009
catalytic activity	2.02879677696451	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.4000306436633	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.2538657804327	bayes_pls_golite062009
binding	1.23408359924301	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.627364990614658	bayes_pls_golite062009
protein binding	0.316566321438364	bayes_pls_golite062009

2

Term	Confidence	Notes
GTP cyclohydrolase I activity	5.27071565931386	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.94513271787536	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.96466418682643	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
binding	1.19587307204017	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
protein binding	0.298277659609786	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle