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Protein Overview: DPOLA_ARATH

General Information:
Name(s) found: DPOLA_ARATH [Swiss-Prot]
Description(s) found:
Found 11 descriptions.
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  • DNA polymerase alpha catalytic subunit OS=Arabidopsis thaliana GN=POLA PE=3 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 1492 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: negative regulation of flower development [NAS]
    leaf morphogenesis [IMP]
    Molecular Function: DNA-directed DNA polymerase activity [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGDNSTETG RRRSRGAEAS SRKDTLERLK AIRQGGIRSA SGGGYDIRLQ KPIFDTVDDE  60
   61 EYDALVSRRR EEARGFVVED GEGGDLGYLD EGEEEDWSKP SGPESTDESD DGGRFSGRLK 120
  121 KKKKGKEQTQ QPQVKKVNPA LKAAATITGE GRLSSMFTSS SFKKVKETDK AQYEGILDEI 180
  181 IAQVTPDESD RKKHTRRKLP GTVPVTIFKN KKLFSVASSM GMKESEPTPS TYEGDSVSMD 240
  241 NELMKEEDMK ESEVIPSETM ELLGSDIVKE DGSNKIRKTE VKSELGVKEV FTLNATIDMK 300
  301 EKDSALSATA GWKEAMGKVG TENGALLGSS SEGKTEFDLD ADGSLRFFIL DAYEEAFGAS 360
  361 MGTIYLFGKV KMGDTYKSCC VVVKNIQRCV YAIPNDSIFP SHELIMLEQE VKDSRLSPES 420
  421 FRGKLHEMAS KLKNEIAQEL LQLNVSNFSM APVKRNYAFE RPDVPAGEQY VLKINYSFKD 480
  481 RPLPEDLKGE SFSALLGSHT SALEHFILKR KIMGPCWLKI SSFSTCSPSE GVSWCKFEVT 540
  541 VQSPKDITIL VSEEKVVHPP AVVTAINLKT IVNEKQNISE IVSASVLCFH NAKIDVPMPA 600
  601 PERKRSGILS HFTVVRNPEG TGYPIGWKKE VSDRNSKNGC NVLSIENSER ALLNRLFLEL 660
  661 NKLDSDILVG HNISGFDLDV LLQRAQACKV QSSMWSKIGR LKRSFMPKLK GNSNYGSGAT 720
  721 PGLMSCIAGR LLCDTDLCSR DLLKEVSYSL TDLSKTQLNR DRKEIAPNDI PKMFQSSKTL 780
  781 VELIECGETD AWLSMELMFH LSVLPLTLQL TNISGNLWGK TLQGARAQRI EYYLLHTFHS 840
  841 KKFILPDKIS QRMKEIKSSK RRMDYAPEDR NVDELDADLT LENDPSKGSK TKKGPAYAGG 900
  901 LVLEPKRGLY DKYVLLLDFN SLYPSIIQEY NICFTTIPRS EDGVPRLPSS QTPGILPKLM 960
  961 EHLVSIRKSV KLKMKKETGL KYWELDIRQQ ALKLTANSMY GCLGFSNSRF YAKPLAELIT1020
 1021 LQGRDILQRT VDLVQNHLNL EVIYGDTDSI MIHSGLDDIE EVKAIKSKVI QEVNKKYRCL1080
 1081 KIDCDGIYKR MLLLRKKKYA AVKLQFKDGK PCEDIERKGV DMVRRDWSLL SKEIGDLCLS1140
 1141 KILYGGSCED VVEAIHNELM KIKEEMRNGQ VALEKYVITK TLTKPPAAYP DSKSQPHVQV1200
 1201 ALRMRQRGYK EGFNAKDTVP YIICYEQGNA SSASSAGIAE RARHPDEVKS EGSRWLVDID1260
 1261 YYLAQQIHPV VSRLCAEIQG TSPERLAECL GLDPSKYRSK SNDATSSDPS TSLLFATSDE1320
 1321 ESKKPATPET EESDSTFWLK LHCPKCQQED STGIISPAMI ANQVKRQIDG FVSMYYKGIM1380
 1381 VCEDESCKHT TRSPNFRLLG ERERGTVCPN YPNCNGTLLR KYTEADLYKQ LSYFCHILDT1440
 1441 QCSLEKMDVG VRIQVEKAMT KIRPAVKSAA AITRSSRDRC AYGWMQLTDI VI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] deduced N/A No confident structure predictions are available.
    2 View Details [148..260] MSA 4.125996 View MSA. No confident structure predictions are available.
    3 View Details [261..340] deduced N/A No confident structure predictions are available.
    4 View Details [341..1303] PSI-BLAST 149.0 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    5 View Details [1304..1492] MSA 1.081987 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • DNA primase activity
    		•  8.57378684936335 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  6.156872069104 bayes_pls_golite062009
  • DNA polymerase activity
    		•  6.10801780003354 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  4.59418010473269 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.66669472409706 bayes_pls_golite062009
  • DNA binding
    		•  2.53092801704688 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.33765586478028 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3098494148191 bayes_pls_golite062009
  • RNA polymerase activity
    		•  2.29514625858236 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  2.29514625858236 bayes_pls_golite062009
  • binding
    		•  1.83109253387887 bayes_pls_golite062009
  • exonuclease activity
    		•  1.68989335095363 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44884785815263 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.41353777396851 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.33509846387956 bayes_pls_golite062009
  • transcription factor activity
    		•  1.09234244981794 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.08077297289305 bayes_pls_golite062009
  • catalytic activity
    		•  1.04899053677564 bayes_pls_golite062009
  • endonuclease activity
    		•  0.991569665925888 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.98331180621651 bayes_pls_golite062009
  • chromatin binding
    		•  0.953917901573139 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.78558451404229 bayes_pls_golite062009
  • transferase activity
    		•  0.784455099927681 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.708753843279937 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.598360955770972 bayes_pls_golite062009
    		• 0.49473250705373 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.433956339585542 bayes_pls_golite062009
  • protein binding
    		•  0.354190470641287 bayes_pls_golite062009
  • nuclease activity
    		•  0.332024848299731 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.283883977748512 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.221046452145313 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.206750180223289 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.19596408995795 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.154583332107704 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0244224367660355 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle