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View Structure Prediction Details

Protein: DPOLA_ARATH
Organism: Arabidopsis thaliana
Length: 1492 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPOLA_ARATH.

Description E-value Query
Range
Subject
Range
DPOLA_ORYSJ - DNA polymerase alpha catalytic subunit OS=Oryza sativa subsp. japonica GN=Os01g0868300 PE=2 SV=2
DPOLA_ORYSA - DNA polymerase alpha catalytic subunit (EC 2.7.7.7) - Oryza sativa (Rice)
1097.0 [0..2] [1492..5]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGDNSTETG RRRSRGAEAS SRKDTLERLK AIRQGGIRSA SGGGYDIRLQ KPIFDTVDDE  60
   61 EYDALVSRRR EEARGFVVED GEGGDLGYLD EGEEEDWSKP SGPESTDESD DGGRFSGRLK 120
  121 KKKKGKEQTQ QPQVKKVNPA LKAAATI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [148-260]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGEGRLSSMF TSSSFKKVKE TDKAQYEGIL DEIIAQVTPD ESDRKKHTRR KLPGTVPVTI  60
   61 FKNKKLFSVA SSMGMKESEP TPSTYEGDSV SMDNELMKEE DMKESEVIPS ETM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [261-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELLGSDIVKE DGSNKIRKTE VKSELGVKEV FTLNATIDMK EKDSALSATA GWKEAMGKVG  60
   61 TENGALLGSS SEGKTEFDLD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [341-1303]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADGSLRFFIL DAYEEAFGAS MGTIYLFGKV KMGDTYKSCC VVVKNIQRCV YAIPNDSIFP  60
   61 SHELIMLEQE VKDSRLSPES FRGKLHEMAS KLKNEIAQEL LQLNVSNFSM APVKRNYAFE 120
  121 RPDVPAGEQY VLKINYSFKD RPLPEDLKGE SFSALLGSHT SALEHFILKR KIMGPCWLKI 180
  181 SSFSTCSPSE GVSWCKFEVT VQSPKDITIL VSEEKVVHPP AVVTAINLKT IVNEKQNISE 240
  241 IVSASVLCFH NAKIDVPMPA PERKRSGILS HFTVVRNPEG TGYPIGWKKE VSDRNSKNGC 300
  301 NVLSIENSER ALLNRLFLEL NKLDSDILVG HNISGFDLDV LLQRAQACKV QSSMWSKIGR 360
  361 LKRSFMPKLK GNSNYGSGAT PGLMSCIAGR LLCDTDLCSR DLLKEVSYSL TDLSKTQLNR 420
  421 DRKEIAPNDI PKMFQSSKTL VELIECGETD AWLSMELMFH LSVLPLTLQL TNISGNLWGK 480
  481 TLQGARAQRI EYYLLHTFHS KKFILPDKIS QRMKEIKSSK RRMDYAPEDR NVDELDADLT 540
  541 LENDPSKGSK TKKGPAYAGG LVLEPKRGLY DKYVLLLDFN SLYPSIIQEY NICFTTIPRS 600
  601 EDGVPRLPSS QTPGILPKLM EHLVSIRKSV KLKMKKETGL KYWELDIRQQ ALKLTANSMY 660
  661 GCLGFSNSRF YAKPLAELIT LQGRDILQRT VDLVQNHLNL EVIYGDTDSI MIHSGLDDIE 720
  721 EVKAIKSKVI QEVNKKYRCL KIDCDGIYKR MLLLRKKKYA AVKLQFKDGK PCEDIERKGV 780
  781 DMVRRDWSLL SKEIGDLCLS KILYGGSCED VVEAIHNELM KIKEEMRNGQ VALEKYVITK 840
  841 TLTKPPAAYP DSKSQPHVQV ALRMRQRGYK EGFNAKDTVP YIICYEQGNA SSASSAGIAE 900
  901 RARHPDEVKS EGSRWLVDID YYLAQQIHPV VSRLCAEIQG TSPERLAECL GLDPSKYRSK 960
  961 SND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 149.0
Match: 1tgoA
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA primase activity 8.57378684936335 bayes_pls_golite062009
DNA-directed DNA polymerase activity 6.156872069104 bayes_pls_golite062009
DNA polymerase activity 6.10801780003354 bayes_pls_golite062009
nucleotidyltransferase activity 4.59418010473269 bayes_pls_golite062009
ribonuclease activity 2.66669472409706 bayes_pls_golite062009
DNA binding 2.53092801704688 bayes_pls_golite062009
nucleic acid binding 2.33765586478028 bayes_pls_golite062009
transcription regulator activity 2.3098494148191 bayes_pls_golite062009
RNA polymerase activity 2.29514625858236 bayes_pls_golite062009
DNA-directed RNA polymerase activity 2.29514625858236 bayes_pls_golite062009
binding 1.83109253387887 bayes_pls_golite062009
exonuclease activity 1.68989335095363 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.44884785815263 bayes_pls_golite062009
exoribonuclease activity 1.41353777396851 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.33509846387956 bayes_pls_golite062009
transcription factor activity 1.09234244981794 bayes_pls_golite062009
damaged DNA binding 1.08077297289305 bayes_pls_golite062009
catalytic activity 1.04899053677564 bayes_pls_golite062009
endonuclease activity 0.991569665925888 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.98331180621651 bayes_pls_golite062009
chromatin binding 0.953917901573139 bayes_pls_golite062009
3'-5' exonuclease activity 0.78558451404229 bayes_pls_golite062009
transferase activity 0.784455099927681 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
0.49473250705373 bayes_pls_golite062009
endodeoxyribonuclease activity 0.48776342704945 bayes_pls_golite062009
structure-specific DNA binding 0.433956339585542 bayes_pls_golite062009
protein binding 0.354190470641287 bayes_pls_golite062009
nuclease activity 0.332024848299731 bayes_pls_golite062009
DNA helicase activity 0.283883977748512 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.221046452145313 bayes_pls_golite062009
single-stranded DNA binding 0.206750180223289 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.19596408995795 bayes_pls_golite062009
5'-3' exonuclease activity 0.154583332107704 bayes_pls_golite062009
transcription activator activity 0.0244224367660355 bayes_pls_golite062009
endoribonuclease activity 0.016619833072142 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1304-1492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATSSDPSTSL LFATSDEESK KPATPETEES DSTFWLKLHC PKCQQEDSTG IISPAMIANQ  60
   61 VKRQIDGFVS MYYKGIMVCE DESCKHTTRS PNFRLLGERE RGTVCPNYPN CNGTLLRKYT 120
  121 EADLYKQLSY FCHILDTQCS LEKMDVGVRI QVEKAMTKIR PAVKSAAAIT RSSRDRCAYG 180
  181 WMQLTDIVI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle