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Protein Overview: CP19C_ARATH

General Information:
Name(s) found: CP19C_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|84028861|sp|Q38867.2|CP19C_ARATH RecName: Full=Peptidyl-prolyl cis-trans isomerase CYP19-3; Short=PPIase CYP19-3; AltName: Full=Rotamase cyclophilin-2; AltName: Full=Cyclophilin of 19 kDa 3; AltName: Full=Cyclophilin-4 [NCBI NR]
  • gi|7572905|emb|CAB87406.1| peptidylprolyl isomerase [Arabidopsis thaliana] [NCBI NR]
  • gi|20465725|gb|AAM20331.1| putative peptidylprolyl isomerase [Arabidopsis thaliana] [NCBI NR]
  • gi|18175915|gb|AAL59950.1| putative peptidylprolyl isomerase [Arabidopsis thaliana] [NCBI NR]
  • gi|15228814|ref|NP_191166.1| ROC2 (ROTAMASE CYCLOPHILIN 2); cyclosporin A binding / peptidyl-prolyl cis-trans isomerase [Arabidopsis thaliana] [NCBI NR]
  • gi|145332871|ref|NP_001078301.1| ROC2 (ROTAMASE CYCLOPHILIN 2); cyclosporin A binding / peptidyl-prolyl cis-trans isomerase [Arabidopsis thaliana] [NCBI NR]
  • pir||T47724 peptidylprolyl isomerase (EC 5.2.1.8) ROC2 - Arabidopsis thaliana [NCBI NR]
  • Peptidyl-prolyl cis-trans isomerase CYP19-3 OS=Arabidopsis thaliana GN=CYP19-3 PE=2 SV=2 [Swiss-Prot]
  • (Q9LYN4) Putative peptidylprolyl isomerase (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) [athaliana3702.FASTAC.txt]
  • putative peptidylprolyl isomerase [Arabidopsis thaliana]gi|18175915|gb|AAL59950.1| putative peptidylprolyl isomerase [Arabidopsis thaliana]gi|7572905|emb|CAB87406.1| peptidylprolyl isomerase [Arabidopsis thaliana]gi|15228814|ref|NP_191166.1| peptidyl-p [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Peptidyl-prolyl cis-trans isomerase [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: ROC2 | ROC2 (rotamase CyP 2); peptidyl-prolyl cis-trans isomerase | chr3:20817966-20818496 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • | Symbols: ROC2 | ROC2 (rotamase CyP 2) | chr3:20817966-20818496 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • peptidylprolyl isomerase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • putative peptidylprolyl isomerase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Peptidyl-prolyl cis-trans isomerase CYP19-3 (PPIase CYP19-3) (Rotamase cyclophilin-2) (Cyclophilin of 19 kDa 3) (Cyclophilin-4) [nr-271106-contam.fasta]
  • ROC2; peptidyl-prolyl cis-trans isomerase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • ROC2 (ROTAMASE CYCLOPHILIN 2); cyclosporin A binding / peptidyl-prolyl cis-trans isomerase [Arabidopsis thaliana] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • | Symbols: ROC2 | rotamase cyclophilin 2 | chr3:20806987-20807517 REVERSE LENGTH=176 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 176 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS]
    Biological Process: signal transduction [ISS]
    response to cadmium ion [IEP]
    protein folding [ISS]
    Molecular Function: cyclosporin A binding [ISS]
    peptidyl-prolyl cis-trans isomerase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANPKVFFDI LIGKMKAGRV VMELFADVTP RTANNFRALC TGENGIGKAG KALHYKGSAF  60
   61 HRIIPGFMCQ GGDFTRGNGT GGESIYGSKF EDENFKLKHT GPGILSMANS GPNTNGSQFF 120
  121 ICTEKTSWLD GKHVVFGKVV DGYNVVKAME DVGSDMGNPS ERVVIEDCGE LKNPSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] PSI-BLAST 69.30103 Cyclophilin (eukaryotic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.46018233647024 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.130251391659493 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle