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Protein Overview: gi|6579197, gi|1...

General Information:
Name(s) found: gi|6579197 [NCBI NR]
gi|15223158 [NCBI NR]
Description(s) found:
Found 8 descriptions.
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  • gi|6579197|gb|AAF18240.1|AC011438_2 T23G18.11 [Arabidopsis thaliana] [NCBI NR]
  • gi|15223158|ref|NP_172303.1| EMB2284/EMB529/POL2A/TIL1 (EMBRYO DEFECTIVE 2284); DNA-directed DNA polymerase [Arabidopsis thaliana] [NCBI NR]
    • Organism: Arabidopsis thaliana
    Length: 2271 amino acids

    Gene Ontology:
    Cellular Component: apoplast [IDA]
    epsilon DNA polymerase complex [IPI]
    Biological Process: embryonic development ending in seed dormancy [IMP][NAS]
    positive regulation of S phase of mitotic cell cycle [IMP]
    negative regulation of long-day photoperiodism, flowering [IMP]
    Molecular Function: nucleic acid binding [IEA]
    nucleotide binding [IEA]
    DNA binding [IEA]
    zinc ion binding [IEA]
    DNA-directed DNA polymerase activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGDNRRRDR KDTRWSKKPK VVNTAEDELE SKLGFGLFSE GETRLGWLLT FSSSSWEDRD  60
   61 TGKVYSCVDL YFVTQDGFSF KTKYKFRPYF YAATKDKMEL ELEAYLRRRY ERQVADIEIV 120
  121 EKEDLDLKNH LSGLQKKYLK ISFDTVQQLM EVKRDLLHIV ERNQAKFDAL EAYESILAGK 180
  181 REQRPQDCLD SIVDLREYDV PYHVRFAIDN DVRSGQWYNV SISSTDVILE KRTDLLQRAE 240
  241 VRVCAFDIET TKLPLKFPDA EYDQIMMISY MVDGQGFLII NREVTACVGE DVEDLEYTPK 300
  301 PEFEGYFKVT NVKNEVELLQ RWFYHMQELK PGIYVTYNGD FFDWPFIERR ASHHGIKMNE 360
  361 ELGFRCDQNQ GECRAKFACH LDCFAWVKRD SYLPQGSHGL KAVTKAKLGY DPLEVNPEDM 420
  421 VRFAMEKPQT MASYSVSDAV ATYYLYMTYV NPFIFSLATI IPMVPDEVLR KGSGTLCEML 480
  481 LMVEVSTYLP QAQAYKANVV CPNKNQADPE KFYQNQLLES ETYIGGHVEC LESGQLIDNL 540
  541 GRDLEYAITV EGKMRMDSIS NYDEVKDEIK EKLEKLRDDP IREEGPLIYH LDVAAMYPNI 600
  601 ILTNRLQVHL ISPPSIVTDE ICTACDFNRP GKTCLRKLEW VWRGVTFMGK KSDYYHLKKQ 660
  661 IESEFVDAGA NIMSSKSFLD LPKVDQQSKL KERLKKYCQK AYKRVLDKPI TEVREAGICM 720
  721 RENPFYVDTV RSFRDRRYEY KTLNKVWKGK LSEAKASGNS IKIQEAQDMV VVYDSLQLAH 780
  781 KCILNSFYGY VMRKGARWYS MEMAGVVTYT GAKIIQNARL LIERIGKPLE LDTDGIWCCL 840
  841 PGSFPENFTF KTIDMKKLTI SYPCVMLNVD VAKNNTNDQY QTLVDPVRKT YKSHSECSIE 900
  901 FEVDGPYKAM IIPASKEEGI LIKKRYAVFN HDGTLAELKG FEIKRRGELK LIKVFQAELF 960
  961 DKFLHGSTLE ECYSAVAAVA DRWLDLLDVC EISCFFWVIY LIGFLSHFLQ NQGKDIADSE1020
 1021 LLDYISESST MSKSLADYGE QKSCAVTTAK RLAEFLGVTM VKDKGLRCQY IVACEPKGTP1080
 1081 VSERAVPVAI FTTNPEVMKF HLRKWCKTSS DVGIRLIIDW SYYKQRLSSA IQKVITIPAA1140
 1141 MQKVANPVPR VLHPDWLHKK VREKDDKFRQ RKLVDMFSSA NKDVVLDTDL PVTKDNVEDI1200
 1201 EDFCKENRPS VKGPKPIARS YEVNKKQSEC EQQESWDTEF HDISFQNIDK SVNYQGWLEL1260
 1261 KKRKWKVTLE KKKKRRLGDL RSSNQVDTHE INQKVGQGRG GVGSYFRRPE EALTSSHWQV1320
 1321 CTIIQLVPSP QSGQFFAWVV VEGLMLKIPL SIPRVFYINS KVPIDEYFQG KCVNKILPHG1380
 1381 RPCYSLTEAC VKIQEDQFKK ESKKRAALLA DPGVEGIYET KVPLEFSAIC QIGCVCKIDN1440
 1441 KAKHRNTQDG WEVGELHMKT TTECHYLKRS IPLVYLYNST STGRAIYVLY CHVSKLMSAV1500
 1501 VVDPFNGNEL LPSALERQFR DSCLELSLDS LSWDGIRFQV HYVDHPEAAK KIIQRAISEY1560
 1561 REENCGPTVA VIECPDFTFM KEGIKALDDF PCVRIPFNDD DNSYQPVSWQ RPAAKIAMFR1620
 1621 CAAAFQWLDR RITQSRYAHV PLGNFGLDWL TFTIDIFLSR ALRDQQQVLW VSDNGVPDLG1680
 1681 GINNEEAFFA DEVQQTSLVF PGAYRKVSVE LKIHNLAVNA LLKSNLVNEM EGGGFMGFEQ1740
 1741 DVNPRGINSN DNTSFDETTG CAQAFRVLKQ LIHSCLTDVR KSKNIYADSI LQRLSWWLCS1800
 1801 PSSKLHDPAL HLMLHKVMQK VFALLLTDLR RLGAIIIYAD FSKVIIDTVK FDLSAAKAYC1860
 1861 ESLLSTVRNR LVSSLLDIHV YDLKSHGLHS FSCHDFCASP LTYNYAGIRA DDEISLDEVT1920
 1921 IEPKWSVARH LPEYIEVWRQ NPHSNQCSFS ENKKHVATHG PFFLDTDAFH LSWQRDFIII1980
 1981 IAKFIFDPWK FAIENKKGSS ESLEAQMIEY LREQIGSTFI NMLVKKVDDI MSHMKEINVS2040
 2041 DASRVSGQAP KGDYSLEFIQ VISAVLALDQ NVQQDVLLKT LFITDFIHKS NLISGNVVLE2100
 2101 TMFTNRAGFF FEWVMRKSLL KYIKVKECAA EAEFLDPGPS FILPNVACSN CDAYRDLDIC2160
 2161 RDPALLTEKE WSCADTQCGK IYDREQMESS LLEMVRQRER MYHMQDVVCI RCNQVKAAHL2220
 2221 TEQCECSGSF RCKESGSEFS KRMEIFMDIA KRQKFRLLEE YISWIIYGPS Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..62] PSI-BLAST 123.0 No description for 2gv9A was found.
    2 View Details [63..146] PSI-BLAST 105.0 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    3 View Details [147..1131] PSI-BLAST 70.0 CRYSTAL STRUCTURE OF ENTEROBACTERIA PHAGE RB69 GP43 DNA POLYMERASE COMPLEXED WITH 8-OXOGUANOSINE CONTAINING DNA
    4 View Details [1132..1242] deduced N/A No confident structure predictions are available.
    5 View Details [1243..2096] FFAS03 3.7 Crystal structure of ESCHERICHIA coli DNA Polymerase II
    6 View Details [2097..2271] MSA 2.038955 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  11.2781960093187 bayes_pls_golite062009
  • DNA polymerase activity
    		•  11.2285838712952 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  8.85826259809475 bayes_pls_golite062009
  • DNA primase activity
    		•  7.3506495327575 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.79232184185512 bayes_pls_golite062009
  • endonuclease activity
    		•  4.4589129578563 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  4.26114862034453 bayes_pls_golite062009
  • transferase activity
    		•  4.02382113115178 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.58611070700103 bayes_pls_golite062009
  • RNA polymerase activity
    		•  2.29514625858236 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  2.29514625858236 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.10426652514018 bayes_pls_golite062009
  • exonuclease activity
    		•  1.68989335095363 bayes_pls_golite062009
  • binding
    		•  1.63261093703427 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62213678119562 bayes_pls_golite062009
  • DNA binding
    		•  1.55767764828811 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.08077297289305 bayes_pls_golite062009
  • catalytic activity
    		•  1.04899053677564 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.863544378011356 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.85780161294346 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.78558451404229 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.78013028675591 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.433956339585542 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.43313823287883 bayes_pls_golite062009
  • chromatin binding
    		•  0.382725239240319 bayes_pls_golite062009
  • nuclease activity
    		•  0.332024848299731 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.283883977748512 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.262305398570872 bayes_pls_golite062009
  • protein binding
    		•  0.254364110020667 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.206750180223289 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.19596408995795 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.193854882336037 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.154583332107704 bayes_pls_golite062009
  • transcription factor activity
    		•  0.093362945686819 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  10.6911520838834 bayes_pls_golite062009
  • DNA polymerase activity
    		•  10.645713605123 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  8.39147983801981 bayes_pls_golite062009
  • DNA primase activity
    		•  6.94341770434315 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.49699229430126 bayes_pls_golite062009
  • endonuclease activity
    		•  4.05835176777658 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  4.04079853250282 bayes_pls_golite062009
  • transferase activity
    		•  3.80228208941612 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.53877834217178 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.98947494839394 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.98947494839394 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.65398017104387 bayes_pls_golite062009
  • binding
    		•  1.65023283997779 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.58132518850155 bayes_pls_golite062009
  • DNA binding
    		•  1.49092185389589 bayes_pls_golite062009
  • exonuclease activity
    		•  1.38951646742998 bayes_pls_golite062009
  • catalytic activity
    		•  0.985794797454925 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.903519456111979 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.883308266169681 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.431057665208185 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.430099678408149 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.427833022898625 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.35941349369351 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.280008381637593 bayes_pls_golite062009
  • protein binding
    		•  0.267061490746095 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.170862363182338 bayes_pls_golite062009
  • chromatin binding
    		•  0.154937729400031 bayes_pls_golite062009
  • nuclease activity
    		•  0.126991239633667 bayes_pls_golite062009
  • transcription factor activity
    		•  0.104696021012086 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.0394470752191727 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.024241485627603 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle