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Protein Overview: HMA1_ARATH

General Information:
Name(s) found: HMA1_ARATH [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Probable cadmium/zinc-transporting ATPase HMA1, chloroplastic OS=Arabidopsis thaliana GN=HMA1 PE=2 SV=2 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 819 amino acids

    Gene Ontology:
    Cellular Component: chloroplast [IDA]
    chloroplast envelope [IDA]
    Biological Process: cellular copper ion homeostasis [IMP]
    calcium ion transport [IGI]
    zinc ion homeostasis [IMP]
    response to light intensity [IMP]
    response to toxin [IGI]
    Molecular Function: ATPase activity [IMP]
    cadmium-transporting ATPase activity [IGI]
    copper-exporting ATPase activity [ISS]
    calcium-transporting ATPase activity [IGI]
    zinc transporting ATPase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPATLTRSS SLTRFPYRRG LSTLRLARVN SFSILPPKTL LRQKPLRISA SLNLPPRSIR  60
   61 LRAVEDHHHD HHHDDEQDHH NHHHHHHQHG CCSVELKAES KPQKMLFGFA KAIGWVRLAN 120
  121 YLREHLHLCC SAAAMFLAAA VCPYLAPEPY IKSLQNAFMI VGFPLVGVSA SLDALMDIAG 180
  181 GKVNIHVLMA LAAFASVFMG NALEGGLLLA MFNLAHIAEE FFTSRSMVDV KELKESNPDS 240
  241 ALLIEVHNGN VPNISDLSYK SVPVHSVEVG SYVLVGTGEI VPVDCEVYQG SATITIEHLT 300
  301 GEVKPLEAKA GDRVPGGARN LDGRMIVKAT KAWNDSTLNK IVQLTEEAHS NKPKLQRWLD 360
  361 EFGENYSKVV VVLSLAIAFL GPFLFKWPFL STAACRGSVY RALGLMVAAS PCALAVAPLA 420
  421 YATAISSCAR KGILLKGAQV LDALASCHTI AFDKTGTLTT GGLTCKAIEP IYGHQGGTNS 480
  481 SVITCCIPNC EKEALAVAAA MEKGTTHPIG RAVVDHSVGK DLPSIFVESF EYFPGRGLTA 540
  541 TVNGVKTVAE ESRLRKASLG SIEFITSLFK SEDESKQIKD AVNASSYGKD FVHAALSVDQ 600
  601 KVTLIHLEDQ PRPGVSGVIA ELKSWARLRV MMLTGDHDSS AWRVANAVGI TEVYCNLKPE 660
  661 DKLNHVKNIA REAGGGLIMV GEGINDAPAL AAATVGIVLA QRASATAIAV ADILLLRDNI 720
  721 TGVPFCVAKS RQTTSLVKQN VALALTSIFL AALPSVLGFV PLWLTVLLHE GGTLLVCLNS 780
  781 VRGLNDPSWS WKQDIVHLIN KLRSQEPTSS SSNSLSSAH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] PSI-BLAST 16.0 Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis
    2 View Details [166..819] PSI-BLAST 110.0 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • metal ion transmembrane transporter activity
    		•  5.4007166857771 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  4.79570221435856 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.61622753861072 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.52484959112186 bayes_pls_golite062009
  • copper chaperone activity
    		•  4.52005853558976 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.12792340516867 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  4.10264569844449 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  3.70964017127302 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  3.5835731964035 bayes_pls_golite062009
  • copper-exporting ATPase activity
    		•  3.51025551246238 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  3.4491370907439 bayes_pls_golite062009
  • copper ion binding
    		•  3.42682876539918 bayes_pls_golite062009
  • metallochaperone activity
    		•  3.38720397498211 bayes_pls_golite062009
  • copper-dependent protein binding
    		•  3.33681042012554 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.27250923701445 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.98847682261773 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.6049784579434 bayes_pls_golite062009
  • transporter activity
    		•  2.43435890488191 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.32163502360862 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.28845421748925 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  2.12771281719585 bayes_pls_golite062009
  • metal ion binding
    		•  1.84981492985167 bayes_pls_golite062009
  • cation binding
    		•  1.84981492985167 bayes_pls_golite062009
  • binding
    		•  1.84926272403445 bayes_pls_golite062009
  • ion binding
    		•  1.84670327188553 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.62116507842838 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.61680623728503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.59572740343301 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.5925429451548 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.59219836319916 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.53883152283038 bayes_pls_golite062009
  • ATPase activity
    		•  1.12732384636594 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.1123150216263 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.04872000948037 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.03270166246194 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.02977205960797 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.02520458852568 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.75722873989123 bayes_pls_golite062009
  • protein binding
    		•  0.670126340301284 bayes_pls_golite062009
  • hydrolase activity
    		•  0.00905715062495194 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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