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View Structure Prediction Details

Protein: HMA1_ARATH
Organism: Arabidopsis thaliana
Length: 819 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMA1_ARATH.

Description E-value Query
Range
Subject
Range
gi|56419437, gi|... - gi|56419437|ref|YP_146755.1| heavy metal-transporting ATPase [Geobacillus kaustophilus HTA426], gi|5...
606.0 [0..4] [787..56]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPATLTRSS SLTRFPYRRG LSTLRLARVN SFSILPPKTL LRQKPLRISA SLNLPPRSIR  60
   61 LRAVEDHHHD HHHDDEQDHH NHHHHHHQHG CCSVELKAES KPQKMLFGFA KAIGWVRLAN 120
  121 YLREHLHLCC SAAAMFLAAA VCPYLAPEPY IKSLQNAFMI VGFPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1p6tA
Description: Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metal ion transmembrane transporter activity 5.4007166857771 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 4.79570221435856 bayes_pls_golite062009
cation transmembrane transporter activity 4.61622753861072 bayes_pls_golite062009
ion transmembrane transporter activity 4.52484959112186 bayes_pls_golite062009
copper chaperone activity 4.52005853558976 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.12792340516867 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 4.10264569844449 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 3.70964017127302 bayes_pls_golite062009
copper-transporting ATPase activity 3.5835731964035 bayes_pls_golite062009
copper-exporting ATPase activity 3.51025551246238 bayes_pls_golite062009
copper ion transmembrane transporter activity 3.4491370907439 bayes_pls_golite062009
copper ion binding 3.42682876539918 bayes_pls_golite062009
metallochaperone activity 3.38720397498211 bayes_pls_golite062009
copper-dependent protein binding 3.33681042012554 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3.27250923701445 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 2.98847682261773 bayes_pls_golite062009
transition metal ion binding 2.6049784579434 bayes_pls_golite062009
transporter activity 2.43435890488191 bayes_pls_golite062009
transmembrane transporter activity 2.32163502360862 bayes_pls_golite062009
substrate-specific transporter activity 2.28845421748925 bayes_pls_golite062009
superoxide dismutase copper chaperone activity 2.12771281719585 bayes_pls_golite062009
metal ion binding 1.84981492985167 bayes_pls_golite062009
cation binding 1.84981492985167 bayes_pls_golite062009
binding 1.84926272403445 bayes_pls_golite062009
ion binding 1.84670327188553 bayes_pls_golite062009
primary active transmembrane transporter activity 1.62116507842838 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 1.61680623728503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.59572740343301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 1.5925429451548 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 1.59219836319916 bayes_pls_golite062009
active transmembrane transporter activity 1.53883152283038 bayes_pls_golite062009
ATPase activity 1.12732384636594 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.1123150216263 bayes_pls_golite062009
pyrophosphatase activity 1.04872000948037 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.03270166246194 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.02977205960797 bayes_pls_golite062009
ATPase activity, coupled 1.02520458852568 bayes_pls_golite062009
cation-transporting ATPase activity 0.75722873989123 bayes_pls_golite062009
protein binding 0.670126340301284 bayes_pls_golite062009
hydrolase activity 0.00905715062495194 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [166-819]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGVSASLDAL MDIAGGKVNI HVLMALAAFA SVFMGNALEG GLLLAMFNLA HIAEEFFTSR  60
   61 SMVDVKELKE SNPDSALLIE VHNGNVPNIS DLSYKSVPVH SVEVGSYVLV GTGEIVPVDC 120
  121 EVYQGSATIT IEHLTGEVKP LEAKAGDRVP GGARNLDGRM IVKATKAWND STLNKIVQLT 180
  181 EEAHSNKPKL QRWLDEFGEN YSKVVVVLSL AIAFLGPFLF KWPFLSTAAC RGSVYRALGL 240
  241 MVAASPCALA VAPLAYATAI SSCARKGILL KGAQVLDALA SCHTIAFDKT GTLTTGGLTC 300
  301 KAIEPIYGHQ GGTNSSVITC CIPNCEKEAL AVAAAMEKGT THPIGRAVVD HSVGKDLPSI 360
  361 FVESFEYFPG RGLTATVNGV KTVAEESRLR KASLGSIEFI TSLFKSEDES KQIKDAVNAS 420
  421 SYGKDFVHAA LSVDQKVTLI HLEDQPRPGV SGVIAELKSW ARLRVMMLTG DHDSSAWRVA 480
  481 NAVGITEVYC NLKPEDKLNH VKNIAREAGG GLIMVGEGIN DAPALAAATV GIVLAQRASA 540
  541 TAIAVADILL LRDNITGVPF CVAKSRQTTS LVKQNVALAL TSIFLAALPS VLGFVPLWLT 600
  601 VLLHEGGTLL VCLNSVRGLN DPSWSWKQDI VHLINKLRSQ EPTSSSSNSL SSAH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 110.0
Match: 1iwoA
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle