Protein Overview: hht3, hht1, hht2

General Information:
Name(s) found:	hht2 / SPBC8D2.04 [Sanger Pombe] hht3 / SPBC1105.11c [Sanger Pombe] hht1 / SPAC1834.04 [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	pir\|\|HSZP3 histone H3.1 [similarity] - fission yeast (Schizosaccharomyces pombe) [NCBI NR] gi\|7019764\|emb\|CAB75772.1\| histone H3 h3.1 [Schizosaccharomyces pombe] [NCBI NR] gi\|5531473\|emb\|CAB50974.1\| histone H3 h3.3 [Schizosaccharomyces pombe] [NCBI NR] gi\|4970\|emb\|CAA28851.1\| Histone H3.1 [Schizosaccharomyces pombe] [NCBI NR] gi\|4963\|emb\|CAA28852.1\| unnamed protein product [Schizosaccharomyces pombe] [NCBI NR] gi\|2950491\|emb\|CAA17819.1\| histone H3 h3.2 [Schizosaccharomyces pombe] [NCBI NR] gi\|2257548\|dbj\|BAA21441.1\| histone H3.1 [Schizosaccharomyces pombe] [NCBI NR] gi\|224835\|prf\|\|1202262D histone H3.1 [NCBI NR] gi\|19115595\|ref\|NP_594683.1\| histone H3 h3.1 [Schizosaccharomyces pombe] [NCBI NR] gi\|19113259\|ref\|NP_596467.1\| histone H3 h3.3 [Schizosaccharomyces pombe] [NCBI NR] gi\|19112359\|ref\|NP_595567.1\| histone H3 h3.2 [Schizosaccharomyces pombe] [NCBI NR] ref\|NP_595557.1\| histone H3.1 [Schizosaccharomyces pombe] [NCBI NR] gi\|122065\|sp\|P09988.2\|H31_SCHPO RecName: Full=Histone H3.1/H3.2 [NCBI NR] histone H3 h3.2 [Sanger Pombe] histone H3 h3.3 [Sanger Pombe] histone H3 h3.1 [Sanger Pombe] Histone H3.1/H3.2 OS=Schizosaccharomyces pombe GN=hht1 PE=1 SV=2 [Swiss-Prot] HISTONE H3: P09988; [pompepVF.fasta] HISTONE H3: P10651; [pompepVF.fasta] \|h3.1\|hht1\|histone h3 [pompepnew.fasta] \|h3.3\|hht3\|histone h3 [pompepnew.fasta] \|h3.2\|hht2\|histone h3 [pompepnew.fasta] \|h3.3\|hht3\|histone H3\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] \|hht2\|h3.2\|histone H3\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] \|hht1\|\|histone H3\|Schizosaccharomyces pombe\|chr 1\|\|\|Manual [pombe041504.fasta] histone H3; histone fold; similar to S. pombe hht1 and hht3; amino terminus K9, K14, S8 are involved in centomeric silencing (IMP) (PMID 14561399); similar to S. cerevisiae YBR010W and YNL031C [Schizosaccharomyces pombe]gi\|19113259\|ref\|NP_596467.1\| histo [nrdb_11152004_Chlamydomonas] \|hht3\|h3.3\|histone H3 h3.3\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] \|hht2\|h3.2\|histone H3 h3.2\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] \|hht1\|\|histone H3 h3.1\|Schizosaccharomyces pombe\|chr 1\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] SPAC1834.04 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] Histone H3.1 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] histone H3 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] SPBC1105.11c [Schizosaccharomyces pombe] [nr-271106-contam.fasta] SPBC8D2.04 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] hypothetical protein SPBC1105.11c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] histone H3.1 [nr-271106-contam.fasta] histone H3.1 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] Histone H3.1/H3.2 [nr-271106-contam.fasta] unnamed protein product [Schizosaccharomyces pombe] [nr-271106-contam.fasta] hypothetical protein SPAC1834.04 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] Histone H3.1/H3.2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hht1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	136 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] nuclear nucleosome [NAS]
Biological Process:	chromatin silencing at centromere [IGI][IMP ] regulation of Ran protein signal transduction [TAS] chromatin assembly or disassembly [NAS] response to DNA damage stimulus [IGI][IMP] nucleosome assembly [IEA][NAS]
Molecular Function:	DNA binding [NAS]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MARTKQTARK STGGKAPRKQ LASKAARKAA PATGGVKKPH RYRPGTVALR EIRRYQKSTE 60 61 LLIRKLPFQR LVREIAQDFK TDLRFQSSAI GALQEAVEAY LVSLFEDTNL CAIHGKRVTI 120 121 QPKDMQLARR LRGERS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..136]	PSI-BLAST	57.09691	Crystal structure of the nucleosome core particle containing the histone domain of macroH2A

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	6.43582244485566	bayes_pls_golite062009
DNA binding	4.49118409263799	bayes_pls_golite062009
nucleic acid binding	4.35201412176948	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
binding	3.27510691458843	bayes_pls_golite062009
transcription factor activity	2.51581622888695	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.38228606466152	bayes_pls_golite062009
transcription repressor activity	2.3574713307436	bayes_pls_golite062009
transcription initiation factor activity	1.57176056919918	bayes_pls_golite062009
transcription corepressor activity	1.30859203490073	bayes_pls_golite062009
histone acetyltransferase activity	1.30425023787663	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.30425023787663	bayes_pls_golite062009
transcription activator activity	1.25487495162413	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
transcription coactivator activity	1.1297723528047	bayes_pls_golite062009
protein binding	1.07873333188144	bayes_pls_golite062009
centromeric DNA binding	1.03586371237592	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009
histone binding	0.218942897869955	bayes_pls_golite062009
sequence-specific DNA binding	0.0852726470007639	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle