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Protein Overview: nas-27

General Information:
Name(s) found: nas-27 / CE36020 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00003545 locus:nas-27 Zinc metalloproteinase nas-27 status:Partially_confirmed UniProt:O17264 protein_id:CCD73622.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 428 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQILPIFFPL LITSLHAIPR GRRAVRNRNE GDINSLVGVG QYLYQGDIAV VKSRARRAVI  60
   61 RQKHKKWKLP MPYSFDRNFP SRSRQRVLEA MQFWSEKTCV TFHENRYVYP HVSIFEGNGC 120
  121 WSFVGKQPSL REQSLSLERS CTDHTFVVAH EIAHTLGFYH EHARGDRDQF ISIDYSNVNP 180
  181 NLTFAFAKES EKQLDHQEAA YEYGSVMHYS VDQFAVNTNR PVIYARDQKF AQAMGNRMRA 240
  241 TFQDVSRMNV LYNCHERCAN TLNRCQQGGY PAPSDCSQCV CPDGFGGNFC ETIEAHSVGQ 300
  301 KDNSDCGGVL WASETSQTFY GAVRTRVHSN SVLPTPEHCF WHIRASQGKS IEIQIKNIIS 360
  361 PCSMSCSFNA LELKLSNFTM TGPRFCCDEH IYNRYSQPKV FQSEGPLAVI GAYARYDYLD 420
  421 FNIEYRAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] PSI-BLAST 34.39794 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    2 View Details [179..428] PSI-BLAST 21.0 Mannose-binding protein associated serine protease 2, MASP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  3.87713655504947 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.50720289959102 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.55317823694462 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.52973705827479 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30803642767787 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.81132179546381 bayes_pls_golite062009
  • catalytic activity
    		•  1.26162753036584 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.71491631246151 bayes_pls_golite062009
    2
    Term Confidence Notes
  • peptidase activity
    		•  1.72322649047672 bayes_pls_golite062009
  • binding
    		•  0.945822943902565 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.759649002808058 bayes_pls_golite062009
  • hydrolase activity
    		•  0.647380592098528 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.58509255952441 bayes_pls_golite062009
  • protein binding
    		•  0.513051538906644 bayes_pls_golite062009
  • catalytic activity
    		•  0.34605294925773 bayes_pls_golite062009
  • receptor binding
    		•  0.0218857243240818 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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