Protein Overview: toh-1

General Information:
Name(s) found:	toh-1 / CE35909 [WormBase]
Description(s) found: Found 18 descriptions. SHOW ALL	WBGene00006591 locus:toh-1 Zinc metalloproteinase nas-26 status:Confirmed UniProt:Q22710 protein_id:CAA88882.4 [WormBase]
Organism:	Caenorhabditis elegans
Length:	414 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	proteolysis [IEA]
Molecular Function:	astacin activity [IEA] metallopeptidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSSLVLILA PLALVAIGEA AFGNSSKIFE IPGLEVMASD KYPHFTTIET VSRTKVHRHR  60
   61 REVIAGQIYD WNSYEIPFQI WGGDYNFQSL IRRGIRMWED STCLRFKENQ QSRDAIRYVL 120
  121 EKGDSCFTEY IGRNGGHQDI IIGSECAEEY VVAHETGHAL GFWHTHQRPD RDRHISINWK 180
  181 NVMEEATASF MPFRSMLQAF GIRQVSPRRV PYDYGSLMHY HAVAHAVKVS DFTIVPKELK 240
  241 YVTTMGTEKM AFLDAKVIND IYCPNACQGR NHLNCLAGGY PDPNNCNVCR CPEGLGGPDC 300
  301 GRLQPSPCGG EIHASDQWQT LSSPSGRDVH CYWRISVPEG SRVRFRLSDG EFPCSYGCQS 360
  361 YVEIKHKLDV RLTGFRSCCY RPKEDTVSES NQIFVIYHPN GRTARFSLRF RRQA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..194]	PSI-BLAST	37.39794	STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
2	View Details	[195..414]	PSI-BLAST	21.0	Mannose-binding protein associated serine protease 2, MASP2

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
peptidase activity	3.87713655504947	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.50720289959102	bayes_pls_golite062009
metallopeptidase activity	2.55317823694462	bayes_pls_golite062009
endopeptidase activity	2.52973705827479	bayes_pls_golite062009
hydrolase activity	2.30803642767787	bayes_pls_golite062009
metalloendopeptidase activity	1.81132179546381	bayes_pls_golite062009
catalytic activity	1.26162753036584	bayes_pls_golite062009
exopeptidase activity	0.71491631246151	bayes_pls_golite062009
binding	0.499447555214981	bayes_pls_golite062009

2

Term	Confidence	Notes
peptidase activity	1.72322649047672	bayes_pls_golite062009
receptor binding	1.07208480206832	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.759649002808058	bayes_pls_golite062009
hydrolase activity	0.647380592098528	bayes_pls_golite062009
endopeptidase activity	0.58509255952441	bayes_pls_golite062009
catalytic activity	0.446188288878443	bayes_pls_golite062009
ErbB-2 class receptor binding	0.437338899624441	bayes_pls_golite062009
binding	0.297494662551346	bayes_pls_golite062009
ErbB-3 class receptor binding	0.17164197559882	bayes_pls_golite062009
growth factor activity	0.04792804882584	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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