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View Structure Prediction Details

Protein: toh-1
Organism: Caenorhabditis elegans
Length: 414 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for toh-1.

Description E-value Query
Range
Subject
Range
gi|187032015, gi... - gi|39580347|emb|CAE64502.1| Hypothetical protein CBG09229 [Caenorhabditis briggsae], gi|187032015|em...
gi|157775011 - gi|157775011|ref|XP_001665571.1| hypothetical protein CBG09229 [Caenorhabditis briggsae AF16]
292.0 [0..1] [411..1]

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Predicted Domain #1
Region A:
Residues: [1-194]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSSLVLILA PLALVAIGEA AFGNSSKIFE IPGLEVMASD KYPHFTTIET VSRTKVHRHR  60
   61 REVIAGQIYD WNSYEIPFQI WGGDYNFQSL IRRGIRMWED STCLRFKENQ QSRDAIRYVL 120
  121 EKGDSCFTEY IGRNGGHQDI IIGSECAEEY VVAHETGHAL GFWHTHQRPD RDRHISINWK 180
  181 NVMEEATASF MPFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.39794
Match: 1astA
Description: STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.87713655504947 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.50720289959102 bayes_pls_golite062009
metallopeptidase activity 2.55317823694462 bayes_pls_golite062009
endopeptidase activity 2.52973705827479 bayes_pls_golite062009
hydrolase activity 2.30803642767787 bayes_pls_golite062009
metalloendopeptidase activity 1.81132179546381 bayes_pls_golite062009
catalytic activity 1.26162753036584 bayes_pls_golite062009
exopeptidase activity 0.71491631246151 bayes_pls_golite062009
binding 0.499447555214981 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [195-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMLQAFGIRQ VSPRRVPYDY GSLMHYHAVA HAVKVSDFTI VPKELKYVTT MGTEKMAFLD  60
   61 AKVINDIYCP NACQGRNHLN CLAGGYPDPN NCNVCRCPEG LGGPDCGRLQ PSPCGGEIHA 120
  121 SDQWQTLSSP SGRDVHCYWR ISVPEGSRVR FRLSDGEFPC SYGCQSYVEI KHKLDVRLTG 180
  181 FRSCCYRPKE DTVSESNQIF VIYHPNGRTA RFSLRFRRQA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1nt0A
Description: Mannose-binding protein associated serine protease 2, MASP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 1.72322649047672 bayes_pls_golite062009
receptor binding 1.07208480206832 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.759649002808058 bayes_pls_golite062009
hydrolase activity 0.647380592098528 bayes_pls_golite062009
endopeptidase activity 0.58509255952441 bayes_pls_golite062009
catalytic activity 0.446188288878443 bayes_pls_golite062009
ErbB-2 class receptor binding 0.437338899624441 bayes_pls_golite062009
binding 0.297494662551346 bayes_pls_golite062009
ErbB-3 class receptor binding 0.17164197559882 bayes_pls_golite062009
growth factor activity 0.04792804882584 bayes_pls_golite062009

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