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Protein Overview: mlc-1

General Information:
Name(s) found: mlc-1 / CE34269 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00003369 locus:mlc-1 Myosin regulatory light chain 1 status:Confirmed UniProt:P19625 protein_id:CCD66901.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 170 amino acids

    Gene Ontology:
    Cellular Component: muscle myosin complex [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: muscle organ development [IGILink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IGILink to PubMed article]
    locomotion [IGILink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    regulation of muscle contraction [IGILink to PubMed article]
    Molecular Function: calcium ion binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKAAKKKSS KKRSGSEAAQ FDQKTIQEFK EAFGIMDQNK DGIIDKSDLK DLYASMGQIA  60
   61 PDSQIDAMIK EASGPINFTV FLTLFGERLT GTDPEATIIG AFAMFDKKDC GKIKEDDLIK 120
  121 ILQNKRGEPL DEDEVKAMYK GKPPIEGGEV DYKAFAHLIT TGAQDELASA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] PSI-BLAST 25.30103 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of muscle
    		•  6.34041234021534 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  6.31366142616096 bayes_pls_golite062009
  • N-terminal myristoylation domain binding
    		•  5.746886320739 bayes_pls_golite062009
  • microfilament motor activity
    		•  5.62061944255026 bayes_pls_golite062009
  • G-protein beta/gamma-subunit binding
    		•  5.51712867097471 bayes_pls_golite062009
  • myosin II heavy chain binding
    		•  5.49688740358168 bayes_pls_golite062009
  • actin binding
    		•  3.96919556235483 bayes_pls_golite062009
  • calcium ion binding
    		•  3.79609619542776 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  3.63014173976595 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • motor activity
    		•  3.25814691068414 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • cation binding
    		•  2.62077305565026 bayes_pls_golite062009
  • metal ion binding
    		•  2.62077305565026 bayes_pls_golite062009
  • ion binding
    		•  2.61312132078717 bayes_pls_golite062009
  • tubulin binding
    		•  2.51210014078446 bayes_pls_golite062009
  • troponin T binding
    		•  2.39237700612893 bayes_pls_golite062009
  • actin filament binding
    		•  2.35534489389161 bayes_pls_golite062009
  • myosin binding
    		•  2.34125070430971 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.29802198409541 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.28098452079347 bayes_pls_golite062009
  • calcium sensitive guanylate cyclase activator activity
    		•  2.25146252368284 bayes_pls_golite062009
  • microtubule binding
    		•  2.17136406283012 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.12961051741613 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.74951443813569 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.51057181410195 bayes_pls_golite062009
  • kinase activity
    		•  1.48008348280256 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.34982153616582 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.29595371278065 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.02715871704923 bayes_pls_golite062009
  • transferase activity
    		•  1.00143834284844 bayes_pls_golite062009
  • actin monomer binding
    		•  0.9954841049256 bayes_pls_golite062009
  • DNA binding
    		•  0.98588735736701 bayes_pls_golite062009
  • nitric-oxide synthase binding
    		•  0.965098383344279 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • cation channel activity
    		•  0.856991182112951 bayes_pls_golite062009
  • guanylate cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • structural molecule activity
    		•  0.800850121197479 bayes_pls_golite062009
  • hydrolase activity
    		•  0.460408471514041 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.438908712437433 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.366129174039334 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.341357838238159 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • myosin II binding
    		•  0.311147527050891 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.308919475701377 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.304496519713588 bayes_pls_golite062009
  • potassium channel activity
    		•  0.260530997378698 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • ER retention sequence binding
    		•  0.234166588492671 bayes_pls_golite062009
  • gated channel activity
    		•  0.175191914660841 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.157059988605635 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • channel activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • receptor binding
    		•  0.0645779132227158 bayes_pls_golite062009
  • ion channel activity
    		•  0.0166394982861724 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle