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Protein Overview: alh-6

General Information:
Name(s) found: alh-6 / CE33403 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00000112 locus:alh-6 status:Partially_confirmed UniProt:Q86N72 protein_id:CCD64342.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 512 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IEALink to PubMed article]
    Biological Process: cellular aldehyde metabolic process [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    proline metabolic process [IEALink to PubMed article]
    negative regulation of transcription [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    proline biosynthetic process [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    valine metabolic process [IEALink to PubMed article]
    betaine biosynthetic process [IEALink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    Molecular Function: 1-pyrroline-5-carboxylate dehydrogenase activity [IEALink to PubMed article]
    DNA binding [IEALink to PubMed article]
    betaine-aldehyde dehydrogenase activity [IEALink to PubMed article]
    proline dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    aldehyde dehydrogenase [NAD(P)+] activity [IEALink to PubMed article]
    methylmalonate-semialdehyde dehydrogenase (acylating) activity [IEALink to PubMed article]
    transcription repressor activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSFAARRSL ITQKCAASTY SGLTSADFLK KKTNEPILEY RKGSKERQDL EAALAFYSKN  60
   61 ITEVPLRIGD KKITNKLEQK QVIPSDHRST LAKYTYATGE QIQEAIDVAL QARGAWERKP 120
  121 LKERAEILLR AADLAAGKYR MKLNASTMLG QGKNIIQAEI DAACELIDFF RFNAVFAMEL 180
  181 EHYEPISTKI TKNTMQFRGM EGFVAAIAPF NFTAIGGNLP TAPALMGNVS LWKPSNTAVL 240
  241 SNYIIYELLE EAGMPPGILS FLPSDGPVFG DVITASPHLS AVNFTGSVPT FKTIWRKVAE 300
  301 NLDNYVTFPK LIGECGGKNF HFVHPSAHVD AVAAGTARSA WEYSGQKCSA CSRMYAPKSI 360
  361 WPKILEKISA IHKEIKLGDV RDGSVFLSAV IDDKAFARLK AYIDFAKTGA DGANVVLGGK 420
  421 CDDKTGYFIE PTLITVTDPK SKLLTEEMFG PVVTVLVYED SKVDEVLATV KDATPYGLTG 480
  481 AVFSQDKEFL YRLATTKNTS FCTGFQGLKN FI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..512] PSI-BLAST 107.0 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.09598561374689 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  4.35175408702761 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  3.27180265380824 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  2.70230501280821 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • aminobutyraldehyde dehydrogenase activity
    		•  2.35958138496479 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  1.75951883819887 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  1.6559690223037 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • binding
    		•  0.868255071997355 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  0.38785102096584 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.258030369394064 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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