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Protein Overview: alh-4

General Information:
Name(s) found: alh-4 / CE33307 [WormBase]
Description(s) found:
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  • WBGene00000110 locus:alh-4 Aldehyde dehydrogenase status:Confirmed UniProt:Q86S57 protein_id:CCD72039.1 [WormBase]
  • gi|32566756|ref|NP_504634.2| ALdehyde deHydrogenase family member (alh-4) [Caenorhabditis elegans] [NCBI NR]
  • gi|27885066|gb|AAO26003.1| Aldehyde dehydrogenase protein 4, isoform c, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • CE33307 WBGene00000110 locus:alh-4 status:Confirmed TR:Q86S57 protein_id:AAO26003.1 [wormpep150.fasta]
  • 33307 WBGene00000110 locus:alh-4 status:Confirmed TR:Q86S57 protein_id:AAO26003.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • ALDH3C1, ALdehyde deHydrogenase (alh-4) [Caenorhabditis elegans]gi|27885066|gb|AAO26003.1| Aldehyde dehydrogenase protein 4, isoform c [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:alh-4 status:Confirmed TR:Q86S57 protein_id:AAO26003.1 [wormpep115.fasta.reversed]
  • CE33307 WBGene00000110 locus:alh-4 status:Confirmed UniProt:Q86S57_CAEEL protein_id:AAO26003.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE33307 WBGene00000110 locus:alh-4 status:Confirmed UniProt:Q86S57_CAEEL protein_id:AAO26003.1| [wormORF-contam.fasta]
  • Aldehyde dehydrogenase protein 4, isoform c [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • ALdehyde deHydrogenase family member (alh-4) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE33307 WBGene00000110 locus:alh-4 status:Confirmed UniProt:Q86S57 protein_id:AAO26003.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE33307 WBGene00000110 locus:alh-4 status:Confirmed UniProt:Q86S57 protein_id:CCD72039.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE33307 WBGene00000110 locus:alh-4 status:Confirmed UniProt:Q86S57 protein_id:CCD72039.1 Aldehyde dehydrogenase [wormpep246-ecoli-contam.fasta]
  • Aldehyde dehydrogenase OS=Caenorhabditis elegans GN=alh-4 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 494 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IEALink to PubMed article]
    Biological Process: cellular aldehyde metabolic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    proline biosynthetic process [IEALink to PubMed article]
    valine metabolic process [IEALink to PubMed article]
    betaine biosynthetic process [IEALink to PubMed article]
    Molecular Function: 1-pyrroline-5-carboxylate dehydrogenase activity [IEALink to PubMed article]
    betaine-aldehyde dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    aldehyde dehydrogenase [NAD(P)+] activity [IEALink to PubMed article]
    methylmalonate-semialdehyde dehydrogenase (acylating) activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFTELVETQ RKYFRTGETK PVKFRKQQLL KLKKFIEENR EALSEAVWKD LRRRHESTEI  60
   61 LEIGMTIQEI DYFLKNIDDW VKPTHVEKTF TTALDKPVIE KDPKGVVLII SPWNYPVSMI 120
  121 LLPMVPAIAA GNTVVIKPSE LSENVAATFE KLIPKYFESK YVTVVNGGIP ETTDLLKERF 180
  181 DHILYTGCPP VAKIIMTAAA KHLTPVTLEL GGKCPVVVED DADIDISAKR IAWGKWLNCG 240
  241 QTCLAPDYIL VNSTVKPKLV AAIRKYVNEF YGEDVKASKD YARMINQRHF DRISGLLDKT 300
  301 QGAVLIGGER DRADLYIPPT VLDVEKSDPF MHDEIFGPVL PIITVQSFSE SLEYIADGEK 360
  361 PLAAYIFTRN EAKVKRLLNE TSSGGVTVND VLMHITVDTL PFGGVGVSGM GRYRGKYGFD 420
  421 TFTHEKSVLH RGFFGESLLA ARYPPLSQQK LDQMRRLTGK RISLNLMNVA TLPIVMASFV 480
  481 FGMLFQVCRG KSAQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..494] PSI-BLAST 116.0 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  4.34495776828926 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  4.2273960318884 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  2.6673036327943 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • acyl-CoA binding
    		•  2.26220696569489 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.02102050611755 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • binding
    		•  1.06673666884196 bayes_pls_golite062009
  • retinoid binding
    		•  0.983782635681687 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.900374761028287 bayes_pls_golite062009
  • protein binding
    		•  0.894945263794726 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  0.882678635212924 bayes_pls_golite062009
  • electron carrier activity
    		•  0.869224905025397 bayes_pls_golite062009
  • hydrolase activity
    		•  0.352374326884796 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.177840865580085 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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