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Protein Overview: clp-4

General Information:
Name(s) found: clp-4 / CE33219 [WormBase]
Description(s) found:
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  • WBGene00000545 locus:clp-4 status:Confirmed UniProt:Q8IAA9 protein_id:CCD73776.1 [WormBase]
  • gi|32564629|ref|NP_497460.2| CaLPain family member (clp-4) [Caenorhabditis elegans] [NCBI NR]
  • gi|27374459|gb|AAO12402.1| Calpain family protein 4, isoform a [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • CE33219 WBGene00000545 locus:clp-4 status:Partially_confirmed TR:Q8IAA9 protein_id:AAO12402.1 [wormpep150.fasta]
  • 33219 WBGene00000545 locus:clp-4 status:Partially_confirmed TR:Q8IAA9 protein_id:AAO12402.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CaLPain family member (80.3 kD) (clp-4) [Caenorhabditis elegans]gi|27374459|gb|AAO12402.1| Calpain family protein 4, isoform a [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:clp-4 status:Partially_confirmed TR:Q8IAA9 protein_id:AAO12402.1 [wormpep115.fasta.reversed]
  • CE33219 WBGene00000545 locus:clp-4 status:Partially_confirmed UniProt:Q8IAA9_CAEEL protein_id:AAO12402.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE33219 WBGene00000545 locus:clp-4 status:Partially_confirmed UniProt:Q8IAA9_CAEEL protein_id:AAO12402.1| [wormORF-contam.fasta]
  • Calpain family protein 4, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CaLPain family member (clp-4) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE33219 WBGene00000545 locus:clp-4 status:Confirmed UniProt:Q8IAA9 protein_id:AAO12402.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE33219 WBGene00000545 locus:clp-4 status:Confirmed UniProt:Q8IAA9 protein_id:CCD73776.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CaLPain family OS=Caenorhabditis elegans GN=clp-4 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 716 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IEALink to PubMed article]
    calcium-dependent cysteine-type endopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANHAKLVDQ EIYRSPVDDF ELNYQEYLND DDDDKQEAPV AVSKAPKGKG SNHGLGCRMK  60
   61 GLFDGFGGTD LKTIMRHLRR RRPKSGQALT NFMLSGNMEK VVDQHVKDFV HHFGRINPEN 120
  121 GRIMGALRGN DFFNFGGLHN NLGNTGKVYL DNLMKGKCGK KRKVHKFKPI VVEELDFGAP 180
  181 KPAVPATPKA PVAPVAPVIP APAVTPQKPK VDEPTYADSV SDFGLDFETE REKCLRNKTL 240
  241 FEDPEFPATA ASLYYRTPPR DRIIWKRPGE IIANPQLITQ GESRFDVKQG ALGDCWFLAA 300
  301 LANITLYDAL FYRIVPPNQS FTENYAGIFH FQFWHYGKWV DVVVDDRLPT VNNQLYYLHS 360
  361 ADNTEFWSAL VEKAYAKLHG GYENLDGGTT AEALEDFTGG LTEYFDLRKS EKAAVLAALV 420
  421 KGMEMGSLFG CSIDADANIK EAQLRNGLVC GHAYSITAIH SITYYGEDTT LLRLRNPWGN 480
  481 EKEWNGAWSD GSSEWSKIDE ATKKQIDVQF ARDGEFWMSF EDFFSNFTQM EVCNLTAEIF 540
  541 DEIAEMTGVN RATETVEEEH QWHEIMEDGE WSSKKGTAGG CNNNPSTYPK NPQFSTFFTA 600
  601 PQSSIEADGN VTVIVAVLQK YRRELRSKGK DVLPIGVSIY SLGAEGTARS PLTAQFFSQN 660
  661 RPIARTTVFV NTREVTVRFR VPPGQYVIVP CTFDAYDDAE FLLRVYANGT LKSSLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..205] PSI-BLAST 22.30103 No description for 2fe0A was found.
    2 View Details [206..716] PSI-BLAST 169.0 Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.28868056127375 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.01472402774099 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.77258741259391 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.896934807256194 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.833714375875501 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.053663265361386 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle