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View Structure Prediction Details

Protein: clp-4
Organism: Caenorhabditis elegans
Length: 716 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for clp-4.

Description E-value Query
Range
Subject
Range
clp-4 - status:Confirmed UniProt:Q8IAA8 protein_id:AAO12403.1
709.0 [0..1] [602..1]

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Predicted Domain #1
Region A:
Residues: [1-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANHAKLVDQ EIYRSPVDDF ELNYQEYLND DDDDKQEAPV AVSKAPKGKG SNHGLGCRMK  60
   61 GLFDGFGGTD LKTIMRHLRR RRPKSGQALT NFMLSGNMEK VVDQHVKDFV HHFGRINPEN 120
  121 GRIMGALRGN DFFNFGGLHN NLGNTGKVYL DNLMKGKCGK KRKVHKFKPI VVEELDFGAP 180
  181 KPAVPATPKA PVAPVAPVIP APAVT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.30103
Match: 2fe0A
Description: No description for 2fe0A was found.

Predicted Domain #2
Region A:
Residues: [206-716]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQKPKVDEPT YADSVSDFGL DFETEREKCL RNKTLFEDPE FPATAASLYY RTPPRDRIIW  60
   61 KRPGEIIANP QLITQGESRF DVKQGALGDC WFLAALANIT LYDALFYRIV PPNQSFTENY 120
  121 AGIFHFQFWH YGKWVDVVVD DRLPTVNNQL YYLHSADNTE FWSALVEKAY AKLHGGYENL 180
  181 DGGTTAEALE DFTGGLTEYF DLRKSEKAAV LAALVKGMEM GSLFGCSIDA DANIKEAQLR 240
  241 NGLVCGHAYS ITAIHSITYY GEDTTLLRLR NPWGNEKEWN GAWSDGSSEW SKIDEATKKQ 300
  301 IDVQFARDGE FWMSFEDFFS NFTQMEVCNL TAEIFDEIAE MTGVNRATET VEEEHQWHEI 360
  361 MEDGEWSSKK GTAGGCNNNP STYPKNPQFS TFFTAPQSSI EADGNVTVIV AVLQKYRREL 420
  421 RSKGKDVLPI GVSIYSLGAE GTARSPLTAQ FFSQNRPIAR TTVFVNTREV TVRFRVPPGQ 480
  481 YVIVPCTFDA YDDAEFLLRV YANGTLKSSL L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 169.0
Match: 1kfuL
Description: Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.28868056127375 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.01472402774099 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.77258741259391 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.07520173658976 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.896934807256194 bayes_pls_golite062009
cytoskeletal protein binding 0.833714375875501 bayes_pls_golite062009
calcium ion binding 0.687204894708051 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
nucleic acid binding 0.313326619937245 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.053663265361386 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle