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Protein Overview: crn-3

General Information:
Name(s) found: crn-3 / CE32797 [WormBase]
Description(s) found:
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  • WBGene00000796 locus:crn-3 status:Confirmed UniProt:Q8I129 protein_id:CAD59140.1 [WormBase]
  • gi|32564304|ref|NP_871964.1| Cell-death-Related Nuclease family member (crn-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|26985796|emb|CAD59140.1| C. elegans protein C14A4.4b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • CE32797 WBGene00000796 locus:crn-3 status:Confirmed TR:Q8I129 protein_id:CAD59140.1 [wormpep150.fasta]
  • 32797 WBGene00000796 locus:crn-3 status:Partially_confirmed TR:Q8I129 protein_id:CAD59140.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • 3'-5' exonuclease (68.1 kD) (2K881C) [Caenorhabditis elegans]gi|26985796|emb|CAD59140.1| Hypothetical protein C14A4.4b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE32797 WBGene00000796 locus:crn-3 status:Partially_confirmed TR:Q8I129 protein_id:CAD59140.1 [wormpep132.fasta]
  • 32797 WBGene00000796 locus:crn-3 status:Confirmed TR:Q8I129 protein_id:CAD59140.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:crn-3 status:Confirmed TR:Q8I129 protein_id:CAD59140.1 [wormpep115.fasta.reversed]
  • CE32797 WBGene00000796 locus:crn-3 status:Confirmed UniProt:Q8I129_CAEEL protein_id:CAD59140.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE32797 WBGene00000796 locus:crn-3 status:Confirmed UniProt:Q8I129_CAEEL protein_id:CAD59140.1| [wormORF-contam.fasta]
  • Cell-death-Related Nuclease family member (crn-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein C14A4.4b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE32797 WBGene00000796 locus:crn-3 status:Confirmed UniProt:Q8I129 protein_id:CAD59140.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • Isoform of G5EBX6, Cell-death-Related Nuclease OS=Caenorhabditis elegans GN=crn-3 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 594 amino acids

    Gene Ontology:
    Cellular Component: nuclear exosome (RNase complex) [IEALink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    intracellular [IEALink to PubMed article]
    exosome (RNase complex) [TASLink to PubMed article]
    Biological Process: embryonic development [IMPLink to PubMed article]
    tRNA processing [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    DNA fragmentation involved in apoptosis [IGILink to PubMed article][IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    apoptotic cell clearance [IDALink to PubMed article]
    RNA processing [IEALink to PubMed article][TASLink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: nucleic acid binding [IEALink to PubMed article]
    3'-5' exonuclease activity [IEALink to PubMed article]
    exonuclease activity [ISSLink to PubMed article]
    ribonuclease activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGEESMPDE EQKQSEEEEE MIRKRTLAMR KKVEEIMRNG AGLVRESNGL PKAGADYELY  60
   61 NSYPTFNTFM KRSEQRLNAL MNKVTKSIGC AMRVPDVGSS VEHYTECVIE AQDNIAERAA 120
  121 TLHEALKKAE LDEIVKVPEF ITKAAPTNRK TEAEVSAAMR TFSANIGTVL AEKFRERREE 180
  181 AAQMVVLEKP QKTYNISSDN SQAPFSSKLT VKHHAIEKRT GIVLHDDDES GRRDWISAET 240
  241 ETEEEHPYIA EILHFKVPEA QLKSAECLKF TALKDTPLTM IDTKEKLEAL TKTLNSVKEF 300
  301 AVDLEHHQMR SYLGLTCLIQ ISTRDEDFII DPFPIWDHVG MLNEPFANPR ILKVFHGSDS 360
  361 DVLWLQRDYG VHVVNLFDTY VKVKKLLNEL DKFVTPFECY QMMMITKEKQ EEEERKEAER 420
  421 KKLEEGDLPK TMFSHHDAPI NRKPEFDAKL LNVDTLKLVP DDPNKPKDPE PSPMEESSSE 480
  481 PQIFDPSRFT DDQLLSKKAM KRKRDAARRN IDVSVVLGES SSSSDPKKKK SDDDAPVEDF 540
  541 DYEKADSSAF EKPVRDNNAD FDPFHQKYRL KNKTKKNMAM KKSSNRQGTI NYKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] PSI-BLAST 8.09691 Divalent metal ions (manganese) bound to T5 5'-exonuclease
    2 View Details [151..594] PSI-BLAST 52.221849 No description for 2hbjA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.845290320008287 bayes_pls_golite062009
  • hydrolase activity
    		•  0.31554871338907 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.12799711467808 bayes_pls_golite062009
  • nuclease activity
    		•  0.0878151841480506 bayes_pls_golite062009
    2
    Term Confidence Notes
  • catalytic activity
    		•  0.722279828632226 bayes_pls_golite062009
  • hydrolase activity
    		•  0.29272620969648 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.24934115119652 bayes_pls_golite062009
  • nuclease activity
    		•  0.239989310123501 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle