Protein Overview: nhr-49

General Information:
Name(s) found:	nhr-49 / CE32693 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00003639 locus:nhr-49 Nuclear hormone receptor family member nhr-49 status:Confirmed UniProt:O45666 protein_id:CAD57702.1 [WormBase] gi\|76803806\|sp\|O45666.2\|NHR49_CAEEL RecName: Full=Nuclear hormone receptor family member nhr-49 [NCBI NR] gi\|32563635\|ref\|NP_871798.1\| Nuclear Hormone Receptor family member (nhr-49) [Caenorhabditis elegans] [NCBI NR] gi\|25814793\|emb\|CAD57702.1\| C. elegans protein K10C3.6c, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] Nuclear hormone receptor family member nhr-49 OS=Caenorhabditis elegans GN=nhr-49 PE=1 SV=2 [Swiss-Prot] [wormpep104.fasta] CE32693 WBGene00003639 locus:nhr-49 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) status:Confirmed SW:O45666 protein_id:CAD57702.1 [wormpep150.fasta] 32693 WBGene00003639 locus:nhr-49 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) status:Confirmed TR:Q8I4H4 protein_id:CAD57702.1 [wormpep130-phg-ecoli-orf-rand.fasta] nuclear Hormone Receptor (55.4 kD) (nhr-49) [Caenorhabditis elegans]gi\|25814793\|emb\|CAD57702.1\| Hypothetical protein K10C3.6c [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas] CE32693 WBGene00003639 locus:nhr-49 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) status:Confirmed TR:Q8I4H4 protein_id:CAD57702.1 [wormpep132.fasta] 32693 WBGene00003639 locus:nhr-49 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) status:Confirmed SW:O45666 protein_id:CAD57702.1 [wormpep150-phg-orf-ecoli-rand.fasta] Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) status:Confirmed TR:Q8I4H4 protein_id:CAD57702.1 [wormpep115.fasta.reversed] CE32693 WBGene00003639 locus:nhr-49 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) status:Confirmed UniProt:O45666 protein_id:CAD57702.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE32693 WBGene00003639 locus:nhr-49 Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) status:Confirmed UniProt:O45666 protein_id:CAD57702.1\| [wormORF-contam.fasta] Hypothetical protein K10C3.6c [Caenorhabditis elegans] [nr-271106-contam.fasta] Nuclear hormone receptor family member nhr-49 [nr-271106-contam.fasta] Nuclear Hormone Receptor family member (nhr-49) [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE32693 WBGene00003639 locus:nhr-49 status:Confirmed UniProt:O45666 protein_id:CAD57702.1 Nuclear hormone receptor family member nhr-49 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	501 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA]
Biological Process:	locomotory behavior [IMP] nematode larval development [IMP] positive regulation of growth rate [IMP ] embryonic development ending in birth or egg hatching [IMP] regulation of transcription, DNA-dependent [IEA] positive regulation of locomotion [IMP]
Molecular Function:	DNA binding [IEA] transcription factor activity [IEA] zinc ion binding [IEA] steroid hormone receptor activity [IEA] sequence-specific DNA binding [IEA] steroid binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYFLDASKH IQLNQIDEES SDDFMDLVDP LAEPCAVCGD KSTGTHYGVI SCNGCKGFFR  60
   61 RTVLRDQKFT CRFNKRCVID KNFRCACRYC RFQKCVQVGM KREAIQFERD PVGSPTSGAS 120
  121 LNGTPFKKDR SPGYENGNSN GVGSNGMGQE NMRTVPQSSS VIDALMEMEA RVNQEMCNRY 180
  181 RRSQIFANGS GGSNGNDTDI QQGSDSGASA FAPPNRPCTT EVDLNEISRT TLLLMVEWAK 240
  241 TINPFMDLSM EDKIILLKNY APQHLILMPA FRSPDTTRVC LFNNTYMTRD NNTDLNGFAA 300
  301 FKTSNITPRV LDEIVWPMRQ LQMREQEFVC LKALAFLHPE AKGLSNSSQI MIRDARNRVL 360
  361 KALYAFILDQ MPDDAPTRYG NILLLAPALK ALTQLLIENM TLTKFFGLAE VDSLLSEFIL 420
  421 DDINDHSTAP VSLQQHLSSP TTLPTNGVSP LNPAGSVGSV SSVSGITPTG MLSATLAAPL 480
  481 AIHPLQSQDS ILNSEQNNHM L

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
transcription regulator activity	5.53061626347066	bayes_pls_golite062009
DNA binding	4.92165988569962	bayes_pls_golite062009
steroid hormone receptor activity	4.81441024181511	bayes_pls_golite062009
nucleic acid binding	4.78024150262074	bayes_pls_golite062009
transcription activator activity	4.53302455129434	bayes_pls_golite062009
sequence-specific DNA binding	4.11614358606713	bayes_pls_golite062009
transcription factor activity	4.0914094580319	bayes_pls_golite062009
nuclear hormone receptor binding	3.91470119037087	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	3.89763470197726	bayes_pls_golite062009
binding	3.85318710398432	bayes_pls_golite062009
transcription repressor activity	3.83878598697109	bayes_pls_golite062009
hormone receptor binding	3.79647267365529	bayes_pls_golite062009
protein binding	3.21524787168952	bayes_pls_golite062009
transcription activator binding	2.98235973123409	bayes_pls_golite062009
transcription factor binding	2.68044489404568	bayes_pls_golite062009
receptor activity	2.62895787183554	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.38308182853979	bayes_pls_golite062009
transcription coactivator activity	2.27959329058894	bayes_pls_golite062009
molecular transducer activity	2.04709877069886	bayes_pls_golite062009
signal transducer activity	2.04709877069886	bayes_pls_golite062009
transcription cofactor activity	1.73827483890179	bayes_pls_golite062009
ecdysteroid hormone receptor activity	1.71585537346083	bayes_pls_golite062009
retinoic acid receptor binding	1.59968001933699	bayes_pls_golite062009
estrogen response element binding	1.56094639526803	bayes_pls_golite062009
estrogen receptor activity	1.47290778095383	bayes_pls_golite062009
retinoid X receptor binding	1.45560845709347	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.34794228300778	bayes_pls_golite062009
promoter binding	1.28787959668198	bayes_pls_golite062009
palmitoyl-CoA hydrolase activity	1.00607914318115	bayes_pls_golite062009
transcription corepressor activity	0.995333369475571	bayes_pls_golite062009
retinoic acid receptor activity	0.853869057774515	bayes_pls_golite062009
protein dimerization activity	0.797229273848179	bayes_pls_golite062009
steroid hormone receptor binding	0.754240851368212	bayes_pls_golite062009
retinoic acid binding	0.676688935879073	bayes_pls_golite062009
protein N-terminus binding	0.57701453824007	bayes_pls_golite062009
thyroid hormone receptor activity	0.49784404390361	bayes_pls_golite062009
structure-specific DNA binding	0.47826452126899	bayes_pls_golite062009
lipid binding	0.475303782949439	bayes_pls_golite062009
protein heterodimerization activity	0.45265806678057	bayes_pls_golite062009
double-stranded DNA binding	0.42652610679613	bayes_pls_golite062009
receptor binding	0.418843034756825	bayes_pls_golite062009
ligand-regulated transcription factor activity	0.202197503742221	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.15737167800277	bayes_pls_golite062009
catalytic activity	0.106902059021677	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.86

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..191]	PSI-BLAST	29.221849	Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
2	View Details	[192..501]	PSI-BLAST	51.09691	Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

Protein Overview: nhr-49

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: