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Protein Overview: nhr-49

General Information:
Name(s) found: nhr-49 / CE32693 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00003639 locus:nhr-49 Nuclear hormone receptor family member nhr-49 status:Confirmed UniProt:O45666 protein_id:CAD57702.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 501 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYFLDASKH IQLNQIDEES SDDFMDLVDP LAEPCAVCGD KSTGTHYGVI SCNGCKGFFR  60
   61 RTVLRDQKFT CRFNKRCVID KNFRCACRYC RFQKCVQVGM KREAIQFERD PVGSPTSGAS 120
  121 LNGTPFKKDR SPGYENGNSN GVGSNGMGQE NMRTVPQSSS VIDALMEMEA RVNQEMCNRY 180
  181 RRSQIFANGS GGSNGNDTDI QQGSDSGASA FAPPNRPCTT EVDLNEISRT TLLLMVEWAK 240
  241 TINPFMDLSM EDKIILLKNY APQHLILMPA FRSPDTTRVC LFNNTYMTRD NNTDLNGFAA 300
  301 FKTSNITPRV LDEIVWPMRQ LQMREQEFVC LKALAFLHPE AKGLSNSSQI MIRDARNRVL 360
  361 KALYAFILDQ MPDDAPTRYG NILLLAPALK ALTQLLIENM TLTKFFGLAE VDSLLSEFIL 420
  421 DDINDHSTAP VSLQQHLSSP TTLPTNGVSP LNPAGSVGSV SSVSGITPTG MLSATLAAPL 480
  481 AIHPLQSQDS ILNSEQNNHM L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] PSI-BLAST 29.221849 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    2 View Details [192..501] PSI-BLAST 51.09691 Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  4.81441024181511 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.91470119037087 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.79647267365529 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription activator binding
    		•  2.98235973123409 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • receptor activity
    		•  2.62895787183554 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.27959329058894 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • signal transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  1.71585537346083 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • estrogen response element binding
    		•  1.56094639526803 bayes_pls_golite062009
  • estrogen receptor activity
    		•  1.47290778095383 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • promoter binding
    		•  1.28787959668198 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  1.00607914318115 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.754240851368212 bayes_pls_golite062009
  • retinoic acid binding
    		•  0.676688935879073 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.47826452126899 bayes_pls_golite062009
  • lipid binding
    		•  0.475303782949439 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.42652610679613 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle