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Protein Overview: mtm-6

General Information:
Name(s) found: mtm-6 / CE32050 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00003478 locus:mtm-6 status:Confirmed UniProt:G5EBF2 protein_id:CAD45596.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 782 amino acids

    Gene Ontology:
    Cellular Component: apical plasma membrane [IDA]
    Biological Process: phospholipid dephosphorylation [IEALink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEALink to PubMed article]
    inositol or phosphatidylinositol phosphatase activity [IEALink to PubMed article]
    protein tyrosine phosphatase activity [IEALink to PubMed article]
    phosphatase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTPSSVTT PLSAWWNNMS LSGIYPSIST STPSSSSSWS SHFVFGGHHH HTNNNTANTP  60
   61 QSTVPPSALS SGYTEDITVA GSLLKDKING LVDSLMGRES VHSGCGYGED GRIAMMVDKV 120
  121 CLVDRLGCQE NLVGTVHVTT THIIFRAENG SKELWLATGL ISSVEKGTLT AAGCMLVIRC 180
  181 KHFQVITLLI SRDKSCQDLY ETLQRAAKPV SVNVTELLAF ENREPVEDVR GWRRLDWNSE 240
  241 MTRQGITKSQ WTESNINEGY TICDTYPNKL WFPTAASTSV LLGSCKFRSR GRLPVLTYFH 300
  301 QQTEAALCRC AQPLTGFSAR CVEDEKLMEL VGKANTNSDN LFLVDTRPRV NAMVNKVQGK 360
  361 GFEDERNYSN MRFHFFDIEN IHVMRASQAR LLDAVTKCRD VTEYWKTLEA SGWLKHVRSV 420
  421 VECSLFLAES ISRGTSCVVH CSDGWDRTSQ VVALCQLLLD PYYRTIHGFQ VLIEKDWLGF 480
  481 GHKFDDRCGH VGALNDEAGK EVSPIFTQWL DCIWQIMQQK PRAFQFNERY LIEMHEHVYS 540
  541 CQFGTFIGNC DKDRRDLNLS KRTKSLWTWM DARHDDYMNP FYSPTAHVAL LDLDTRAARF 600
  601 TVWTAMYNRF DNGLQPRERL EDLTMAAMEH VGVLESHVAQ LRTRLAELKT QQNQQITSTN 660
  661 TPTNMVDSGM SSATDDLKNL SLSHPLDPLS STLPILERAT SQESGVMDSS LYYPDEALTK 720
  721 YSLKWQPLRG ADRCSNPACR GEFSSTIERR IHCHLCGMIF CRRCLKVSAD ERERVCDKCK 780
  781 TD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..666] PSI-BLAST 1000.0 Crystal Structure of Myotubularin-related protein 2 complexed with phosphate
    2 View Details [667..782] PSI-BLAST 15.045757 Hrs

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  7.03758345564381 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.82821455971597 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.83769298632658 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.3097342170423 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  4.03975183132282 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  2.60529675907066 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  2.05577133553311 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.95004535887255 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
    		•  1.72084618199574 bayes_pls_golite062009
  • hydrolase activity
    		•  1.5596484415033 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  1.51576958903553 bayes_pls_golite062009
  • binding
    		•  1.42026750513729 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • protein binding
    		•  1.07441758584517 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.724257798127697 bayes_pls_golite062009
  • kinase activity
    		•  0.541255358115631 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.532875179381704 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.359793029026564 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.291525352733402 bayes_pls_golite062009
  • receptor activity
    		•  0.191946218805025 bayes_pls_golite062009
  • transferase activity
    		•  0.0332461821062801 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.29426800901388 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.10798835472416 bayes_pls_golite062009
  • protein binding
    		•  1.42349040268084 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.14205751938857 bayes_pls_golite062009
  • phospholipid binding
    		•  0.80395524110653 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.725027596988427 bayes_pls_golite062009
  • kinase activity
    		•  0.708043480245413 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.566514217996404 bayes_pls_golite062009
  • phosphatidylinositol binding
    		•  0.41867699028241 bayes_pls_golite062009
  • transferase activity
    		•  0.245705939593188 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.146643072181441 bayes_pls_golite062009
  • protein kinase activity
    		•  0.135620195215743 bayes_pls_golite062009
  • lipid binding
    		•  0.131242568396849 bayes_pls_golite062009
  • DNA binding
    		•  0.0738691893159623 bayes_pls_golite062009
  • transporter activity
    		•  0.0727830088566982 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.072726677214319 bayes_pls_golite062009
  • lipid kinase activity
    		•  0.0124079901149139 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.54

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle