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Protein Overview: nas-38

General Information:
Name(s) found: nas-38 / CE31188 [WormBase]
Description(s) found:
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  • WBGene00003554 locus:nas-38 Zinc metalloproteinase nas-38 status:Partially_confirmed UniProt:Q20942 protein_id:CCD69445.1 [WormBase]
  • gi|57012921|sp|Q20942.2|NAS38_CAEEL RecName: Full=Zinc metalloproteinase nas-38; AltName: Full=Nematode astacin 38; Flags: Precursor [NCBI NR]
  • gi|25150905|ref|NP_508120.2| Nematode AStacin protease family member (nas-38) [Caenorhabditis elegans] [NCBI NR]
  • gi|21629499|gb|AAA83298.2| Nematode astacin protease protein 38, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • Zinc metalloproteinase nas-38 OS=Caenorhabditis elegans GN=nas-38 PE=3 SV=2 [Swiss-Prot]
  • [wormpep88.fasta]
  • CE31188 WBGene00003554 locus:nas-38 status:Partially_confirmed SW:Q20942 protein_id:AAA83298.2 [wormpep150.fasta]
  • 31188 WBGene00003554 locus:nas-38 status:Partially_confirmed TR:Q20942 protein_id:AAA83298.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • metalloprotease family member (83.3 kD) (XB181) [Caenorhabditis elegans]gi|21629499|gb|AAA83298.2| Nematode astacin protease protein 38 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE31188 WBGene00003554 locus:nas-38 status:Partially_confirmed TR:Q20942 protein_id:AAA83298.2 [wormpep132.fasta]
  • 31188 WBGene00003554 locus:nas-38 status:Partially_confirmed SW:Q20942 protein_id:AAA83298.2 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:nas-38 status:Partially_confirmed TR:Q20942 protein_id:AAA83298.2 [wormpep115.fasta.reversed]
  • CE31188 WBGene00003554 locus:nas-38 status:Partially_confirmed UniProt:Q20942 protein_id:AAA83298.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE31188 WBGene00003554 locus:nas-38 status:Partially_confirmed UniProt:Q20942 protein_id:AAA83298.2| [wormORF-contam.fasta]
  • Nematode astacin protease protein 38 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Nematode AStacin protease family member (nas-38) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Zinc metalloproteinase nas-38 precursor (Nematode astacin 38) [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE31188 WBGene00003554 locus:nas-38 status:Partially_confirmed UniProt:Q20942 protein_id:CCD69445.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE31188 WBGene00003554 locus:nas-38 status:Partially_confirmed UniProt:Q20942 protein_id:CCD69445.1 Zinc metalloproteinase nas-38 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 745 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSPSYNRHI IIASCFCCLL IFSSAARVPK ASKKHLARVK QLLNDEAERH NTLIQSDSVT  60
   61 VFDDIQRNPN TGVHHDELAV NNADEYFQGD VDLSEQQVKI IEDQFTQGKR EKRKIGRNPL 120
  121 YKKWDTRGPI SFDYAESIPF QTRQKIRSAM LLWQQHTCLR FEEGGPNVDR LEFFDGGGCS 180
  181 SFVGRVGGTQ GISISTPGCD VVGIISHEIG HALGIFHEQA RPDQERHIAI NYNNIPLSRW 240
  241 NNFQAVGENH AETYNLPYDT GSVMHYGPYG FASDPYTPTI RTLERVQQST IGQRAGPSFL 300
  301 DYQAINMAYG CTESCADLPC LRNGYTHPNN CSMCACPEGL SGRYCEQVYP SNAQCARGKL 360
  361 TRERHINERE CYQSAIWTAT KEVKYITSPN YPDKFPIDTE CNWIIAAPIE GRVFMEFEGD 420
  421 FDFLCEDTCD KAYVEVKYHS DKRLTGARYC CSLLPKNRFI SFKNEMIIIM RGYRSSGAGF 480
  481 KAKFWSNLGE PEGVSTPLPP TTAPLPEISE TTQKPEPTTV QSTTTYTTAI PRRTAKKQFF 540
  541 TRKPITIPLT PLTSSSTTTE STTVSSTTQS TTWLPTEPSF ATGETEITTA SPTITLFPSL 600
  601 STILPPINSL AGVLPSTQAP DIINSVLECG CGAWSEWQGE CSQQCGGCGH RLRKRECKKE 660
  661 ACRKEEKRPC NFSACPDGTN FLINNAEFHI LWRGCCVGLF RSGDQCSALE TESNPFFKII 720
  721 NSLLNIQDAK NNDTLIAKRM MRGEH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] deduced N/A No confident structure predictions are available.
    2 View Details [118..222] PSI-BLAST 40.69897 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [223..497] PSI-BLAST 30.09691 Mannose-binding protein associated serine protease 2, MASP2
    4 View Details [498..745] PSI-BLAST 5.09691 Solution structure of dimeric form of properdin by X-ray solution scattering and analytical ultracentrifugation

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.87713655504947 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.50720289959102 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.55317823694462 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.52973705827479 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30803642767787 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.81132179546381 bayes_pls_golite062009
  • catalytic activity
    		•  1.26162753036584 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.71491631246151 bayes_pls_golite062009
  • binding
    		•  0.210557818016724 bayes_pls_golite062009
    3
    Term Confidence Notes
  • peptidase activity
    		•  1.72322649047672 bayes_pls_golite062009
  • protein binding
    		•  1.279921135544 bayes_pls_golite062009
  • binding
    		•  1.20290372802439 bayes_pls_golite062009
  • receptor binding
    		•  0.82821806463643 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.759649002808058 bayes_pls_golite062009
  • hydrolase activity
    		•  0.647380592098528 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.58509255952441 bayes_pls_golite062009
  • catalytic activity
    		•  0.34605294925773 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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