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Protein Overview: pink-1

General Information:
Name(s) found: pink-1 / CE28904 [WormBase]
Description(s) found:
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  • WBGene00017137 locus:pink-1 Serine\/threonine-protein kinase pink-1, mitochondrial status:Confirmed UniProt:Q09298 protein_id:CCD68737.1 [WormBase]
  • gi|39932726|sp|Q09298.2|PINK1_CAEEL RecName: Full=Serine/threonine-protein kinase pink-1, mitochondrial; AltName: Full=PTEN-induced kinase 1 homolog; Flags: Precursor [NCBI NR]
  • gi|17532823|ref|NP_495017.1| PINK (PTEN-induced kinase) homolog family member (pink-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|15277377|gb|AAK93845.1|U23484_17 Pink (pten-induced kinase) homolog protein 1, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • (Q09298) Putative serine/threonine-protein kinase EEED8.9 (EC 2.7.11.1) [Swiss-Prot]
  • Serine/threonine-protein kinase pink-1, mitochondrial OS=Caenorhabditis elegans GN=pink-1 PE=3 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE28904 WBGene00017137 locus:pink-1 status:Partially_confirmed SW:Q09298 protein_id:AAK93845.1 [wormpep150.fasta]
  • 28904 WBGene00017137 status:Partially_confirmed SW:Q09298 protein_id:AAK93845.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • ring finger protein eeed8.9 (73.1 kD) (2F684) [Caenorhabditis elegans]gi|15277377|gb|AAK93845.1| Hypothetical protein EEED8.9 [Caenorhabditis elegans]gi|39932726|sp|Q09298|YQO9_CAEEL Putative serine/threonine-protein kinase EEED8.9 [nrdb_11152004_Chlamydomonas]
  • CE28904 WBGene00017137 status:Partially_confirmed SW:Q09298 protein_id:AAK93845.1 [wormpep132.fasta]
  • 28904 WBGene00017137 locus:pink-1 status:Partially_confirmed SW:Q09298 protein_id:AAK93845.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • status:Partially_confirmed TN:AAK93845 protein_id:AAK93845.1 [wormpep115.fasta.reversed]
  • CE28904 status:Partially_confirmed protein_id:AAK93845.1 [wormpep80.hongbin]
  • CE28904 WBGene00017137 locus:pink-1 status:Partially_confirmed UniProt:Q09298 protein_id:AAK93845.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE28904 WBGene00017137 locus:pink-1 status:Partially_confirmed UniProt:Q09298 protein_id:AAK93845.1| [wormORF-contam.fasta]
  • Serine/threonine-protein kinase pink-1, mitochondrial precursor (PTEN-induced kinase 1 homolog) [nr-271106-contam.fasta]
  • Pink (pten-induced kinase) homolog protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • PINK (PTEN-induced kinase) homolog family member (pink-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE28904 WBGene00017137 locus:pink-1 status:Confirmed UniProt:Q09298 protein_id:CCD68737.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE28904 WBGene00017137 locus:pink-1 status:Confirmed UniProt:Q09298 protein_id:CCD68737.1 Serine\/threonine-protein kinase pink-1, mitochondrial [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 641 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    mitochondrion [IDA]
    Biological Process: protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMKRFGKAA YRIANELVAK GGRLPIFQRF LPRIFPATYN LGVHVVLKKA PFPRQNALRI  60
   61 ARLVTRHGRV FRPFSSVIIE RHRFQNQNDW RRKFQPIRKE LPRNVDLVER IRQIFGNSLR 120
  121 YNEDLKSTEW PNRIDSYEFG EFLGQGCNAA VYSARLANSD AESSGNTHYG AGFNEVTNIL 180
  181 AEIPPVSKVA QKKFPLAIKL MFNFEHDRDG DAHLLKSMGN ELAPYPNAAK LLNGQMGTFR 240
  241 PLPAKHPNVV RIQTAFIDSL KVLPDAIERY PDALHTARWY ESIASEPKTM YVVMRRYRQT 300
  301 LHEYVWTRHR NYWTGRVIIA QLLEACTYLH KHKVAQRDMK SDNILLEYDF DDEIPQLVVA 360
  361 DFGCALACDN WQVDYESDEV SLGGNAKTKA PEIATAVPGK NVKVNFEMAD TWAAGGLSYE 420
  421 VLTRSNPFYK LLDTATYQES ELPALPSRVN FVARDVIFDL LKRDPNERVK PNIAANALNL 480
  481 SLFRMGEDVK QMMEKCGISQ MTTLLAGSSK VLSQKINSRL DKVMNLITAE TIMANLAPHL 540
  541 ISRAERQLRA TFLSRMNRED IWRSLQYFFP AGVQLDTPAT SSDCLETISS LMSSFSNDSE 600
  601 NYEKQQKPAK NGYNNVPLLL RNVIRTDADG INGIVHRVRS K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] PSI-BLAST 12.045757 No description for 2uvmA was found.
    2 View Details [67..486] PSI-BLAST 56.0 CHICKEN SRC TYROSINE KINASE
    3 View Details [487..549] PSI-BLAST 73.30103 Crystal Structure of ROCK 1 bound to fasudil
    4 View Details [550..641] PSI-BLAST 6.39794 No description for 2ux0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein kinase activity
    		•  2.62276884151553 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  2.50483678534826 bayes_pls_golite062009
  • binding
    		•  2.30345550898346 bayes_pls_golite062009
  • kinase activity
    		•  1.85072548514531 bayes_pls_golite062009
  • protein binding
    		•  1.56366829708752 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.41631708186013 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.35441545960336 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.16822929050287 bayes_pls_golite062009
  • transferase activity
    		•  0.876865688160088 bayes_pls_golite062009
  • catalytic activity
    		•  0.673946834085468 bayes_pls_golite062009
  • ATP binding
    		•  0.261039303134118 bayes_pls_golite062009
  • nucleotide binding
    		•  0.251407596862474 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.219959447941569 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.215871730509016 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.202000470670323 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.201952708752098 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.199843476277027 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.169343150501543 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.128999677980942 bayes_pls_golite062009
  • actin binding
    		•  0.123104851483289 bayes_pls_golite062009
  • tubulin binding
    		•  0.121530745814215 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.117998167722028 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.117645147388277 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle