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Protein Overview: unc-103

General Information:
Name(s) found: unc-103 / CE27805 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00006830 locus:unc-103 status:Confirmed UniProt:G5EDE3 protein_id:CAA84644.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 791 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: mating behavior [IMPLink to PubMed article]
    ion transport [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of oviposition [NASLink to PubMed article]
    regulation of muscle contraction [IMPLink to PubMed article]
    Molecular Function: ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSTNHTGI IQHHPSQSQQ QATTSSGAGN AVASQAKQLM VVLQSGSYKV LSLGADVLPE  60
   61 YKLQPTRIHH CTIVHYSPFK AVWDWIILLL VIYTAVFTPY VAAFLLRELQ DTAKKSRFTE 120
  121 PLEIVDLIVD IMFIVDIIIN FRTTYVNEND EACQVVSDPG KIATHYFKGW FIIDMVAAVP 180
  181 FDLLLVSTNS DETTTLIGLL KTARLLRLVR VARKLDRYSE YGAAVLLLLM ATFALIAHWL 240
  241 ACIWYAIGSA ELSHKEYTWL HQLSKQLAQP YTSTNGTIPT GGPTLKSRYV TSLYFTLSTI 300
  301 TSIGFGNVSA TTDSEKIFTI IMMILGSLMY ASVFGNVSAI IQRLYSGTAR YHTEMSRLRE 360
  361 FIRFHQIPNP LRQRLEEYFQ HAWSYTNGID MNLVLKGFPD CLQADICLHL NRNLLSGCAA 420
  421 FAGSTPGCLR ALSMRFRTTH SPPGDTLVHR GDILTGLYFI ARGSVEILND DNTVMGILGK 480
  481 DDIFGENPLL YDEVGKSSCN VRALTYCDLH KILRDDLLDV LDMYPEFAET FCKNLTITYN 540
  541 LRDDAQSLRK KFDRHKLLRM SSSMNKDRYT TPPDGDHGNA AVRRSAESVS RCDSNPIDRR 600
  601 QSAGSRSSSR CSPPHAALTA TRSEATPLLR RSTNHHEEDD ALFDDIRAFA RGNTVTMSPT 660
  661 VAGNSVSPTT AIHNDGIHSQ QLSDRSDDYE ERRANMFGRR LESIESQMER MQNKFNSDME 720
  721 TLIKLVKEQS IIRNNGSSNE EPNARYRPNN YISSAIRLPN GGGGGVVDEM RVSRLSSHEP 780
  781 PTPTQETDTI L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..364] PSI-BLAST 42.045757 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [365..608] PSI-BLAST 29.045757 HCN2J 443-645 in the presence of cGMP
    3 View Details [609..791] MSA 1.493991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • intracellular cyclic nucleotide activated cation channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • ion channel activity
    		•  8.54258173089828 bayes_pls_golite062009
  • gated channel activity
    		•  8.40583491856766 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  8.39905773163311 bayes_pls_golite062009
  • channel activity
    		•  8.39905773163311 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  8.39470084162975 bayes_pls_golite062009
  • cation channel activity
    		•  8.37340171056317 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  7.52815183034083 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  7.07543487134503 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.92543918512794 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.90247452112447 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.68461701924174 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  3.17407714154852 bayes_pls_golite062009
  • potassium channel activity
    		•  3.16645830461177 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.42821009576643 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.37087453697521 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.11234289483733 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.00131870009595 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.99073791328042 bayes_pls_golite062009
  • binding
    		•  1.39247933044015 bayes_pls_golite062009
  • signal transducer activity
    		•  0.758143612871078 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.758143612871078 bayes_pls_golite062009
  • protein binding
    		•  0.71319432010926 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.362412435891451 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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