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Protein Overview: tax-4

General Information:
Name(s) found: tax-4 / CE27352 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00006526 locus:tax-4 Cyclic nucleotide-gated cation channel status:Confirmed UniProt:Q03611 protein_id:CAB63418.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 733 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    thermotaxis [IGILink to PubMed article][IMPLink to PubMed article]
    neuron projection morphogenesis [IMPLink to PubMed article]
    thermosensory behavior [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    regulation of neuron differentiation [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    olfactory behavior [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAEPAPDP TNPSTSGLAP TTNGIGSPPP TASAATKFSI LTKFLRRKNQ VHTTTAQQNE  60
   61 FMQKYMPNGN SNAVQPAATG GQPASSDGGS AIEVPPPKES YAVRIRKYLA NYTQDPSTDN 120
  121 FYYWTCVVTV AYIYNLLFVI ARQVFNDLIG PSSQSLCRFY NGTLNSTTQV ECTYNMLTNM 180
  181 KEMPTYSQYP DLGWSKYWHF RMLWVFFDLL MDCVYLIDTF LNYRMGYMDQ GLVVREAEKV 240
  241 TKAYWQSKQY RIDGISLIPL DYILGWPIPY INWRGLPILR LNRLIRYKRV RNCLERTETR 300
  301 SSMPNAFRVV VVVWYIVIII HWNACLYFWI SEWIGLGTDA WVYGHLNKQS LPDDITDTLL 360
  361 RRYVYSFYWS TLILTTIGEV PSPVRNIEYA FVTLDLMCGV LIFATIVGNV GSMISNMSAA 420
  421 RTEFQNKMDG IKQYMELRKV SKQLEIRVIK WFDYLWTNKQ SLSDQQVLKV LPDKLQAEIA 480
  481 MQVHFETLRK VRIFQDCEAG LLAELVLKLQ LQVFSPGDFI CKKGDIGREM YIVKRGRLQV 540
  541 VDDDGKKVFV TLQEGSVFGE LSILNIAGSK NGNRRTANVR SVGYTDLFVL SKTDLWNALR 600
  601 EYPDARKLLL AKGREILKKD NLLDENAPEE QKTVEEIAEH LNNAVKVLQT RMARLIVEHS 660
  661 STEGKLMKRI EMLEKHLSRY KALARRQKTM HGVSIDGGDI STDGVDERVR PPRLRQTKTI 720
  721 DLPTGTESES LLK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..430] PSI-BLAST 38.522879 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [431..496] PSI-BLAST 18.154902 No description for 2q0aA was found.
    3 View Details [497..733] PSI-BLAST 19.0 Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cyclic nucleotide-gated ion channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  9.72053268940283 bayes_pls_golite062009
  • cation channel activity
    		•  9.48749374439976 bayes_pls_golite062009
  • ion channel activity
    		•  9.4846197809463 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  9.3929063879608 bayes_pls_golite062009
  • channel activity
    		•  9.25176207085973 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  9.25176207085973 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  9.2472549851376 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • gated channel activity
    		•  9.19042473454294 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.57272328088253 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.54930851487319 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.54400173845933 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.34760703274696 bayes_pls_golite062009
  • potassium channel activity
    		•  5.29889968906368 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.1138025954757 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  4.96516802098805 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  4.52895684111035 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.95109938608832 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • protein binding
    		•  1.86347494944834 bayes_pls_golite062009
  • signal transducer activity
    		•  1.7487659479534 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.7487659479534 bayes_pls_golite062009
  • binding
    		•  1.59096092728475 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.52941414851886 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.40720858109605 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33862527414723 bayes_pls_golite062009
  • DNA binding
    		•  1.17942022803543 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.930640481652164 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.910527807644534 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.848189810874263 bayes_pls_golite062009
  • transcription factor activity
    		•  0.720377542376114 bayes_pls_golite062009
  • transcription activator activity
    		•  0.659469524274627 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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