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Protein Overview: uaf-1

General Information:
Name(s) found: uaf-1 / CE27339 [WormBase]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • WBGene00006697 locus:uaf-1 Splicing factor U2AF 65 kDa subunit status:Confirmed UniProt:P90978 protein_id:CCD62278.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 496 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    spliceosomal complex [ISSLink to PubMed article]
    Biological Process: embryonic development [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    mRNA processing [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: nucleic acid binding [IEALink to PubMed article]
    RNA binding [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDHQDGMKL EDIERQFLDV AQREGGLEAI QPTTGPLENE ENLKSSTGGG GGEDDNDRKK  60
   61 RKRSRSRDRD TRRRSRSRDR GERRGGGGGG DRDRSRSRER RRGGGGRDEP RRRGGDDEAR 120
  121 SRREPEPQKP REPKKYRFWD VPPTGFETTT PMEYKNMQAA GQVPRGSVQS AVPVVGPSVT 180
  181 CQSRRLYVGN IPFGCNEEAM LDFFNQQMHL CGLAQAPGNP ILLCQINLDK NFAFIEFRSI 240
  241 DETTAGMAFD GINFMGQQLK VRRPRDYQPS QNTFDMNSRM PVSTIVVDSA NKIFIGGLPN 300
  301 YLTEDQVKEL LCSFGPLKAF SLNVDSQGNS KGYAFAEYLD PTLTDQAIAG LNGMQLGDKQ 360
  361 LVVQLACANQ QRHNTNLPNS ASAIAGIDLS QGAGRATEIL CLMNMVTEDE LKADDEYEEI 420
  421 LEDVRDECSK YGIVRSLEIP RPYEDHPVPG VGKVFVEFAS TSDCQRAQAA LTGRKFANRT 480
  481 VVTSYYDVDK YHNRQF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] MSA 3.313996 View MSA. No confident structure predictions are available.
    2 View Details [158..289] PSI-BLAST 34.69897 No description for 2g4bA was found.
    3 View Details [290..394] PSI-BLAST 17.045757 Splicing factor U2AF 65 KDa subunit
    4 View Details [395..496] PSI-BLAST 14.0 Splicing factor U2AF 65 KDa subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • U1 snRNA binding
    		•  3.02511982045347 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.92450390013691 bayes_pls_golite062009
  • DNA binding
    		•  1.8021593476478 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15127506309683 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.425042944899091 bayes_pls_golite062009
  • transporter activity
    		•  0.417047632648771 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.288834004308736 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.288804044686487 bayes_pls_golite062009
  • snoRNA binding
    		•  0.0568636182001701 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00171911393626201 bayes_pls_golite062009
    4
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • U1 snRNA binding
    		•  3.02511982045347 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.92450390013691 bayes_pls_golite062009
  • DNA binding
    		•  1.8021593476478 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15127506309683 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.425042944899091 bayes_pls_golite062009
  • transporter activity
    		•  0.417047632648771 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.288834004308736 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.288804044686487 bayes_pls_golite062009
  • snoRNA binding
    		•  0.0568636182001701 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00171911393626201 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle