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Protein Overview: hsp-60

General Information:
Name(s) found: hsp-60 / CE27244 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00002025 locus:hsp-60 Chaperonin homolog Hsp-60, mitochondrial status:Confirmed UniProt:P50140 protein_id:CCD73746.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 568 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    cellular protein metabolic process [IEALink to PubMed article]
    protein folding [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    unfolded protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRLARKGLQ TAVVRSYAKD VKFGAEGRQA MLVGVNLLAD AVSVTMGPKG RNVIIEQSWG  60
   61 SPKITKDGVT VAKSIDLKDK YQNLGAKLIQ DVANKANEEA GDGTTCATVL ARAIAKEGFE 120
  121 SIRQGGNAVE IRRGVMNAVE VVVAELKKIS KKVTTPEEIA QVATISANGD TVVGNLISDA 180
  181 MKKVGTTGVI TVKDGKTLND ELELIEGMKF DRGYISPYFI TSAKGAKVEY EKALVLLSEK 240
  241 KISQVQDIVP ALELANKLRR PLVIIAEDVD GEALTTLVLN RLKVGLQVVA IKAPGFGDNR 300
  301 KNTLKDMGIA TGATIFGDDS NLIKIEDITA NDLGEVDEVT ITKDDTLLLR GRGDQTEIEK 360
  361 RIEHITDEIE QSTSDYEKEK LNERLAKLSK GVAVLKIGGG SEVEVGEKKD RVTDALCATR 420
  421 AAVEEGIVPG GGVALLRSLT ALKNYKAANE DQQIGVNIVK KALTQPIATI VKNAGLEPSS 480
  481 IIDEVTGNSN TSYGYDALNG KFVDMFEAGI IDPTKVVRTA LQDASGVASL LATTECVVTE 540
  541 IPKEEAVGGP AGGMGGMGGM GGMGGMGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..568] PSI-BLAST 167.0 GroEL, E domain; GroEL, A domain; GroEL, I domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.60116801069598 bayes_pls_golite062009
  • misfolded protein binding
    		•  2.60932901317399 bayes_pls_golite062009
  • lipopolysaccharide binding
    		•  2.08823822762317 bayes_pls_golite062009
  • binding
    		•  2.07154556649829 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.90846357786961 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.85422470116133 bayes_pls_golite062009
  • protein binding
    		•  1.68543685258552 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.787685249362834 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.75018875403424 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.69634667457441 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.682843768728088 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.680378643689288 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.650832159017275 bayes_pls_golite062009
  • ATPase activity
    		•  0.584574936611857 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • insulin binding
    		•  0.54263404774246 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.44104272460881 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • cell surface binding
    		•  0.326492680678891 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.280457039468896 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0491351110520448 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle