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Protein Overview: exl-1

General Information:
Name(s) found: exl-1 / CE24922 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00001371 locus:exl-1 Chloride intracellular channel exl-1 status:Confirmed UniProt:O45405 protein_id:CAB04193.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 238 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: chloride transport [IEALink to PubMed article]
    Molecular Function: voltage-gated chloride channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTFSLWLPA GSNNVHPCGD PYAHHLFMRC LYHAKHDPTM KFDVKTTNVN KTSQEFKNTG  60
   61 LRRMPGISAE ESGETQTFET EDDILDFLEY LKPERGDDEE AENATCDLFR QFARFVKDVE 120
  121 HRDTAFNTEL LRLDKYLSEQ ETKFLISDDV THIDCLVLTR LHSIRVAAKM LKNYEIPADL 180
  181 SHVLDYLKAG YATEMFRVSC PSDQEIVLHW TELKDTPRLS AKDRAKLVRE EPVFSFSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 33.39794 Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • anion channel activity
    		•  3.43309717940669 bayes_pls_golite062009
  • chloride channel activity
    		•  3.43309717940669 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  2.95357085969061 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.80355375991545 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.57358006453916 bayes_pls_golite062009
  • ion channel activity
    		•  1.93467867578363 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.85548385190106 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.85004112385169 bayes_pls_golite062009
  • channel activity
    		•  1.85004112385169 bayes_pls_golite062009
  • voltage-gated chloride channel activity
    		•  1.53793640572798 bayes_pls_golite062009
  • voltage-gated anion channel activity
    		•  1.53793640572798 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.48840493532061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.48840493532061 bayes_pls_golite062009
  • transporter activity
    		•  1.27462890839069 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07599729927609 bayes_pls_golite062009
  • gated channel activity
    		•  1.02378767677496 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.861215137904704 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.677675994999412 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.661169709002081 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  0.659499362710003 bayes_pls_golite062009
  • protein disulfide isomerase activity
    		•  0.659499362710003 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  0.536401864923239 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.52671047749426 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.32476916216195 bayes_pls_golite062009
  • DNA binding
    		•  0.278017923256183 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.00678211696545472 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle