Protein Overview: dhc-1

General Information:
Name(s) found:	dhc-1 / CE23997 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00000962 locus:dhc-1 Dynein heavy chain, cytoplasmic status:Partially_confirmed UniProt:Q19020 protein_id:CCD64267.1 [WormBase] gi\|495017\|gb\|AAC37251.1\| dynein heavy chain [Caenorhabditis elegans] [NCBI NR] gi\|2494203\|sp\|Q19020.1\|DYHC_CAEEL RecName: Full=Dynein heavy chain, cytoplasmic; AltName: Full=Dynein heavy chain, cytosolic; Short=DYHC [NCBI NR] gi\|17506419\|ref\|NP_491363.1\| Dynein Heavy Chain family member (dhc-1) [Caenorhabditis elegans] [NCBI NR] gi\|13384544\|gb\|AAK21472.1\| Dynein heavy chain protein 1 [Caenorhabditis elegans] [NCBI NR] Dynein heavy chain, cytoplasmic OS=Caenorhabditis elegans GN=dhc-1 PE=1 SV=1 [Swiss-Prot] [wormpep67.fasta] CE23997 WBGene00000962 locus:dhc-1 dynein heavy chain status:Partially_confirmed SW:Q19020 protein_id:AAK21472.1 [wormpep150.fasta] 23997 WBGene00000962 locus:dhc-1 dynein heavy chain status:Partially_confirmed SW:Q19020 protein_id:AAK21472.1 [wormpep130-phg-ecoli-orf-rand.fasta] dynein heavy chain, LEThal LET-354 (dhc-1) [Caenorhabditis elegans]gi\|13384544\|gb\|AAK21472.1\| Dynein heavy chain protein 1 [Caenorhabditis elegans]gi\|495017\|gb\|AAC37251.1\| dynein heavy chaingi\|2494203\|sp\|Q19020\|DYHC_CAEEL Dynein heavy chain, cytosolic [nrdb_11152004_Chlamydomonas] locus:dhc-1 dynein heavy chain status:Partially_confirmed SW:Q19020 protein_id:AAK21472.1 [wormpep115.fasta.reversed] CE23997 locus:dhc-1 dynein heavy chain status:Partially_confirmed [wormpep80.hongbin] CE23997 WBGene00000962 locus:dhc-1 dynein heavy chain status:Partially_confirmed UniProt:Q19020 protein_id:AAK21472.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE23997 WBGene00000962 locus:dhc-1 dynein heavy chain status:Partially_confirmed UniProt:Q19020 protein_id:AAK21472.1\| [wormORF-contam.fasta] Dynein heavy chain, cytosolic (DYHC) [nr-271106-contam.fasta] Dynein heavy chain protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta] Dynein Heavy Chain family member (dhc-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] dynein heavy chain [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE23997 WBGene00000962 locus:dhc-1 dynein heavy chain status:Partially_confirmed UniProt:Q19020 protein_id:CCD64267.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE23997 WBGene00000962 locus:dhc-1 status:Partially_confirmed UniProt:Q19020 protein_id:CCD64267.1 Dynein heavy chain, cytoplasmic [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	4568 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] cytoplasm [IDA] cell cortex [IDA] spindle [IDA] dynein complex [IEA] proteinaceous extracellular matrix [IEA] gas vesicle [IEA]
Biological Process:	embryonic cleavage [IMP] spindle organization [IMP] pronuclear migration [IMP ] synaptic vesicle transport [IMP] embryonic development ending in birth or egg hatching [IMP ] cytokinesis [IMP] cell adhesion [IEA] blood coagulation [IEA] synaptic transmission, GABAergic [IGI][IMP] microtubule-based movement [IEA] gas vesicle organization [IEA]
Molecular Function:	nucleotide binding [IEA] ATPase activity [IEA] ATP binding [IEA] microtubule motor activity [IEA] nucleoside-triphosphatase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSGNESSII QPPNLKTAAE GDVKEYIVQV VTSHFGLSPR DQTTLDVELT AATTFITDFI  60
   61 NEADKNVIVV DRVVAREQGD QPAGAESGGE ESAPATFQVH DGLFMTDRGQ AMMFVKQSNV 120
  121 IEAEKKIATQ VSAFPLNGGS AWEQLHFLMS RLLNPYCKSF IGQSGRGERD GDKLAPTVQK 180
  181 CFTEAEAALL HLQQNIDIPE INLVVNQHIL DAIEQAGKEN RRAKIEDLGD LVEDANFLNA 240
  241 LQSGCNRWVK EIRKVTQLER DPSSGTSLQE MTFWLNLERA LLKISQKRDG EEVTLTLEAL 300
  301 KCGKRFHATV GFDSDNGLKQ KLAVVQDYNT LMKEFPLSEL VSATDVPKLM HAVVGIFLHL 360
  361 RKLRSTKYPL QRALRLVEAI SRDLNSQLLK VLSSYNLMRT PIAEFNEIMS QCQALFSKWD 420
  421 DEYDKFIALL RDINKKKRDD PSKLSWKVTA VHKRLETRLM QILQFRKQHE QFRTVIERVL 480
  481 RPVGNGSRER EQLMIDSSEG EKSPDEQVDI AYEFLKNVDF LDVDSPAWEN AFKRYEDQIG 540
  541 VVETAITTRL KSQLESSRNS NEMFSIFSRY NALFIRPRIR GAIYEYQTRL INRVKEDINE 600
  601 LQARFTKARG EQGVKIMQTV GLPPFSAKIM WIRNYERQLQ RYMKRVEDVL GKQWENHVDG 660
  661 RQLKADGDNF KVKLNTQPMF DEWVESVQSQ NWTLPNKILT VDRVQVDGRM QLQLKINYHS 720
  721 DSSVLYKEVS HLKSMGFRVP LKIVNWAHQA NQMRPSATSL IEAARTFASV NAALASVQGV 780
  781 DSLLASYKKD IQNQLIEGAT LGWDSYKVDQ YQLKLAETVN TYQERCEELL NVVRIVNADL 840
  841 NVLKSCRYDK ETIENLLTSI QKGVDQLSLG NYSNLAQWVN TLDRQIETIL ARRVEDAIRV 900
  901 WTLVFSQSEE VEELRERQVV LPTVKNVVVD LCMTAQTLYI SPSTRETREK ILEQLYEWHS 960
  961 VCTAQMRISG KRFQMVMNEE IEPETYHNIL NVMPEGQACL EKAYDCVNGI MSDLEEYLSE1020
 1021 WLSYQSLWVL QAEQLFEMLG TSLSKWMKTL MEIRKGRLVF DTQDTRKVIF PVSVEYGKAQ1080
 1081 QKILFKYDYW HKEMLVKFGA VVGDEMQKFF NSVSKWRNVL ETQSVDGGST SDTIGLISFV1140
 1141 QSLKKQTKSG QDAVDLYRSS QRLLNQQRYQ FPAQWLYSEN VEGEWSAFTE ILSLRDASIQ1200
 1201 TQMMNLQTKF AQEDELVEKR TVETLTEWNK SKPVEGAQRP QEALNVITAF EAKLNKLTEE1260
 1261 RNKMRKARVA LDLSDSAHAP SEGDKLTVAT EELAAMKDVW KALQPVYTGI DEAKEKTWLS1320
 1321 VQPRKIRQSL DELMNQLKQL PVKCRTYKSY EHVKQMLHTY GKMNMLVAEL KSEALKERHW1380
 1381 HQMMKEMRVN WNLSDLTLGQ VWDADILRHE HTIKKILLVA QGEMALEEFL REMREYWQNY1440
 1441 EVELVNYQNK TRLIKGWDDL FNKLKEHQNS LSAMKLSPYY KQFEESAQSW DEKLNKINAM1500
 1501 FDVWIDVQRR WVYLEGLFSG SAEISTLLPF ESSRFATITT DVLALMKKVA ASPRILDVVN1560
 1561 MQGAQRLLER LADMLAKIQK ALGEYLERER SSFPRFYFVG DEDLLEIMGN SKDITRIQKH1620
 1621 LKKMFAGITA IDINEEDRSI TAFHSREGEK VDLVKIVSTK DVRINDWLQA LEAEMKHTLA1680
 1681 RQLAASLTHF SKMNIQTMTT DDYVEWLDKF PAQVITLTAE IWWCDEMEKT LADGKGAENV1740
 1741 EQAVVKTLEL LADSVLKEQP PIRRKKMEAL ITELVHKRDT CRKLVSMKIR AANDFGWLQC1800
 1801 MRFYFDPKQV DPVRCCVVKM ANSQFFYGFE YLGIQERLVR TPLTDRCYLT MTQALHSRLG1860
 1861 GSPFGPAGTG KTESVKALGH QLGRFVLVFN CDETFDFQAM GRILVGLCQV GAWGCFDEFN1920
 1921 RLEERMLSAV SQQIQTIQEA VRAGGDMSVD LVGKRLNVNS NIGIFITMNP GYSGRSNLPD1980
 1981 NLKQLFRSLA MTQPDRQLIA QVMLFSQGFR TAETLANKIV PLFILCKEQL SDQCHYDFGL2040
 2041 RALKYVLVSA GNIKRDKLDK MGSAALEDVA EQQMLIQSVC ETLVPKLVNE DIALLFSLLS2100
 2101 DVFPGIHYTA NQMRELRQQL STVCDEHLLI YSDVQGEMGS MWLDKVLQLY QITNLNHGLM2160
 2161 LVGSSGSGKT MAWKVLLKAL ERWENVEGVA HVIDAKAMSK DSLYGVMDPN TREWTDGLFT2220
 2221 SVIRKIIDNV RGEADRRQWI IFDGDVDPEW VENLNSVLDD NKLLTLPNGE RLSIPPNVRI2280
 2281 IFEVADLKYA TLATVSRCGM VWFSEEVVTS EMLFERYLSI IRRVPLDSDS AISFSSSSAP2340
 2341 VNLIGEDAKP TRSIEIQRTA ALALQTHFSP DGIVPGSLKY AVSELEHIMP PTPQRLLSSF2400
 2401 FSMMSYSIRK IVSHDEGLID DSVEIDQIQS FVLRSMLTNL VWAFSGDGKW KSREMMSDFI2460
 2461 RQATTISLPP NQQACLIDYE VQLSGDWQPW LSKVPTMEIE SHRVAAADLV VPTIDTVRHE2520
 2521 MLLAAWLAEH KPLVLCGPPG SGKTMTLLAA LRSQQEMEVV NVNFSSSTTP ELLLRTFDHY2580
 2581 CEYRRTPNGV VLAPVQLSQW LVIFCDEINL PAPDKYGTQR VISFLRQLVE LNGFYRTSDH2640
 2641 SWVSLERIQF VGACNPPTDP GRHPMTSRFL RHVPIVYVDY PGQTSLQQIY GTFNRAMLKM2700
 2701 TPAVRGLADQ LTNAMVDVYL ASQEHFTQDD QPHYVYSPRE LTRWVRGISE AITPLESLSA2760
 2761 EQLVRLWAHE AIRLFQDRLV TEEEREWTDK LVDTTAERYF GNACRLDEAL KRPLLYSCWL2820
 2821 SRNYVPVTRE ELQDYVSARL KGFYEEELDV KLVLFDQMLD HVLRIDRIYR QSQGHLLLIG2880
 2881 TAGAGKTTLS RFVAWLNGLS VFQLKVHSKY TAADFDEDMR TVLRRAGCRN EKLCFIMDES2940
 2941 NMLDTGFLER LNTLLANGEV PGLFEGDEHT TLMTQIKEGA QRQGLILDSH DELYKWFTQQ3000
 3001 VMRNLHVVFT MNPSGSGLRE RASTSPALFN RCVLNWFGDW SENALYQVGS ELTRTMDLDR3060
 3061 TDYEGSVRLT PSCELVPSQP TYRDAVVNTL CLVHKTVQKF NEMETKKGHR VMACTPRHFL3120
 3121 DFIKQFMSLF HEKRSDLEEE KIHLNIGLNK ISETEEQVKE LQKSLKLKSN ELQEKKEAAN3180
 3181 LKLKEMLGDQ QKAEEEKKFS EQLQKELAEQ LKQMAEKKTF VENDLAQVEP AVAEAQTAVQ3240
 3241 GIKKSQLVEV KSMSSPPVTV KLTLEAICIL LGENVGTDWK AIRQVMMKDD FMTRILQFDT3300
 3301 ELLTPEILKQ MEKYIQNPDW EFDKVNRASV ACGPMVKWAR AQLLYSTMLH KVEPLRNELK3360
 3361 RLEQEAAKKT QEGKVVDVRI TELEESIGKY KEEYAQLIGQ AENIKQDLLS VQEKVNRSTE3420
 3421 LLSSLRSERD RWSSGSAGFS QQMDSLVGDA LLSSAFLAYA GYYDQMLRDE IFHKWFNHVV3480
 3481 NAGLHFRHDL ARIEYLSTVD DRLQWQLNSL PVDDLCTENA IMLHRFNRYP LIIDPSGQAV3540
 3541 EYIMKQFAGK NIQKTSFLDE SFRKNLESAL RFGNSLLVQD VEAYDPILNP VLNREVKRAG3600
 3601 GRVLITIGDQ DIDLSPSFQI FMITRDSTVE FSPDICSRVT FVNFTVTSSS LASQCLNQVL3660
 3661 RSERPDVDKK RNDLLKLQGE FAVRLRHLEK ALLAALNESK GKILDDNSVI ETLEKLKNEA3720
 3721 AEVAQKSAET DKVMAEVDAV SAQYQRLSTA CSHIYHTLQQ LNEIHFLYHY SLDFLVEIFT3780
 3781 HVLKTPELSS TTDYAKRLRI ITTSLFQTVF RRVSRGMLHT DKVLLALLLM RIHIRSNPSA3840
 3841 PAYEQHFDLL LGRSDFVAKN DEADSTIPGG LDFLTVENKK SIAKARKVVG FENVFAHLQH3900
 3901 NSAAVTSWLT NDNPESNVPV VWDDADGKLS PLCIAMNSLI VVHALRPDRL MASAHRVVST3960
 3961 AFDDHFMQQD KVVDILSIVD NEVSPSEPVL LCSATGYDAS GKIEDLAVET NRQLTSIAIG4020
 4021 SAEGFNQADS ALGTATKSGR WVLLKNVHLA PSWLAQLEKR LHSMKPHAQF RLFLTAEIHP4080
 4081 KLPSSILRAS RVVVFEPATG LKANLLRSLS SIPPQRLTKA PTERSRLYLL VCWLHALVQE4140
 4141 RLRYTPLGWS TAYEFSDADL RVACDTLDAA VDAVAQGRPN VEPERLPWTT LRTLLSQCIY4200
 4201 GGKIDNQFDQ VLLDCVLENL FTAKSFEQDH VLIPKYDGDD SLFTPNMSKK DQMIGWVEEL4260
 4261 KNEQLPAWLG LPNNAEKVLL TKRGESMLRN MLKVTDEELA FNEDGKEEVK PQWMAQLGEL4320
 4321 AKQWLQLLPK EIVKMRRTVE NIKDPLFRFF EREVNLGSQL LKDIRRDLNE ISAVCRAEKK4380
 4381 QNNETRALAA SLQKGEVPTG WKRYTVPREV TVMDWMTDLN ERLKQLIRIG GADNLKRETF4440
 4441 WLGGTFSPEA YITATRQQVA QANTWSLEQL NLHIHIGRTD STDVFRISGI DIRGAKSVGG4500
 4501 NKLELCELVK SECDIVEFSW KQDVADGTRL PLYLYGDRRQ LISPLAFHLS SATVFYQRGV4560
 4561 ALVANSTL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	hcp-1	hcp1 IP from december2004	Cheeseman, I.M., et al. (2005)
View Run	hcp-2	hcp2 ip from december	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: dhc-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: