Protein Overview: nhr-3

General Information:
Name(s) found:	nhr-3 / CE18798 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00003602 locus:nhr-3 Nuclear hormone receptor family member nhr-3 status:Confirmed UniProt:Q9XTJ4 protein_id:CAA16168.1 [WormBase] gi\|4139070\|gb\|AAD03680.1\| nuclear receptor NHR-3 [Caenorhabditis elegans] [NCBI NR] gi\|3878017\|emb\|CAA16168.1\| C. elegans protein H01A20.1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|17568425\|ref\|NP_510423.1\| Nuclear Hormone Receptor family member (nhr-3) [Caenorhabditis elegans] [NCBI NR] pir\|\|T43344 nuclear receptor NHR-3 - Caenorhabditis elegans [NCBI NR] gi\|10720139\|sp\|Q9XTJ4.1\|NHR3_CAEEL RecName: Full=Nuclear hormone receptor family member nhr-3 [NCBI NR] gi\|10197967\|gb\|AAG15118.1\| nuclear receptor NHR-3 [Caenorhabditis elegans] [NCBI NR] Nuclear hormone receptor family member nhr-3 OS=Caenorhabditis elegans GN=nhr-3 PE=2 SV=1 [Swiss-Prot] [wormpep67.fasta] CE18798 WBGene00003602 locus:nhr-3 Zinc finger, C4 type (two domains) status:Confirmed SW:Q9XTJ4 protein_id:CAA16168.1 [wormpep150.fasta] 18798 WBGene00003602 locus:nhr-3 Zinc finger, C4 type (two domains) status:Confirmed SW:Q9XTJ4 protein_id:CAA16168.1 [wormpep130-phg-ecoli-orf-rand.fasta] nuclear Hormone Receptor (51.3 kD) (nhr-3) [Caenorhabditis elegans]gi\|3878017\|emb\|CAA16168.1\| Hypothetical protein H01A20.1 [Caenorhabditis elegans]gi\|10197967\|gb\|AAG15118.1\| nuclear receptor NHR-3 [Caenorhabditis elegans]gi\|4139070\|gb\|AAD03680.1\| nucl [nrdb_11152004_Chlamydomonas] CE18798 WBGene00003602 locus:nhr-3 Zinc finger, C4 type (two domains) status:Partially_confirmed SW:Q9XTJ4 protein_id:CAA16168.1 [wormpep132.fasta] locus:nhr-3 Zinc finger, C4 type (two domains) status:Confirmed SW:Q9XTJ4 protein_id:CAA16168.1 [wormpep115.fasta.reversed] CE18798 locus:nhr-3 Zinc finger, C4 type (two domains) status:Confirmed SW:Q9XTJ4 protein_id:CAA16168.1 [wormpep80.hongbin] CE18798 WBGene00003602 locus:nhr-3 Zinc finger, C4 type (two domains) status:Confirmed UniProt:Q9XTJ4 protein_id:CAA16168.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE18798 WBGene00003602 locus:nhr-3 Zinc finger, C4 type (two domains) status:Confirmed UniProt:Q9XTJ4 protein_id:CAA16168.1\| [wormORF-contam.fasta] Hypothetical protein H01A20.1 [Caenorhabditis elegans] [nr-271106-contam.fasta] nuclear receptor NHR-3 [Caenorhabditis elegans] [nr-271106-contam.fasta] Nuclear Hormone Receptor family member (nhr-3) [Caenorhabditis elegans] [nr-271106-contam.fasta] Nuclear hormone receptor family member nhr-3 [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE18798 WBGene00003602 locus:nhr-3 status:Confirmed UniProt:Q9XTJ4 protein_id:CAA16168.1 Nuclear hormone receptor family member nhr-3 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	463 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC][IEA]
Biological Process:	response to ethanol [IEP] regulation of transcription, DNA-dependent [IEA] regulation of transcription [TAS]
Molecular Function:	DNA binding [IEA] transcription factor activity [IEA] zinc ion binding [IEA] transcription regulator activity [TAS] steroid hormone receptor activity [IEA] sequence-specific DNA binding [IEA] steroid binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDTQSPFSF AAALLQCGSP GQTFSMESLL KPELGEYSPS GENGIDGEES TICSVCCDEA  60
   61 SGRHYGVVAC FGCKGFFRRT VRAGKNYVCR YSKKCRIDKA GRNVCRSCRF QKCLEVGMEP 120
  121 DAIRPDRDKT GRQKNPRRNT EGSIKKVSVG SILGDLPCLN KFKDDSDDAA TSPSSRADSA 180
  181 PMDLRPSFID ESVLTTLTEI ENIVIQLQDN FETNQQSLPP MGEAITKPSL IAARTLLNFN 240
  241 GAKGVADANC VSSNLRRMIV FTFDYINTLR PIADLHPSEK LVIARSIISP FCILFCGYQS 300
  301 VAIEAPEHDS IYLPSGHKLP ASQLLFTKDS DQKKYILLEN KADNVRRNMT EMIIQQLRRL 360
  361 NVTKTEMVAL KAIMALDHNV KGLSAESCEL LVVARESVQN ALFSHLIATF GTAEATSRFA 420
  421 HLLLLIASAT RVAYSLSSFF QLSRDVNYEI DYVLEELLFL DRI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
transcription regulator activity	5.53061626347066	bayes_pls_golite062009
DNA binding	4.92165988569962	bayes_pls_golite062009
nucleic acid binding	4.78024150262074	bayes_pls_golite062009
transcription activator activity	4.53302455129434	bayes_pls_golite062009
sequence-specific DNA binding	4.11614358606713	bayes_pls_golite062009
transcription factor activity	4.0914094580319	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	3.89763470197726	bayes_pls_golite062009
binding	3.85318710398432	bayes_pls_golite062009
protein binding	3.21524787168952	bayes_pls_golite062009
transcription factor binding	2.68044489404568	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.38308182853979	bayes_pls_golite062009
steroid hormone receptor activity	2.30195937604451	bayes_pls_golite062009
transcription repressor activity	2.20686235000733	bayes_pls_golite062009
receptor activity	2.07573173722434	bayes_pls_golite062009
transcription cofactor activity	1.73827483890179	bayes_pls_golite062009
nuclear hormone receptor binding	1.60419100774741	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.34794228300778	bayes_pls_golite062009
retinoic acid receptor binding	1.28118886948947	bayes_pls_golite062009
transcription coactivator activity	1.23834725221597	bayes_pls_golite062009
molecular transducer activity	1.19872119297817	bayes_pls_golite062009
signal transducer activity	1.19872119297817	bayes_pls_golite062009
retinoid X receptor binding	0.99801784942981	bayes_pls_golite062009
retinoic acid receptor activity	0.853869057774515	bayes_pls_golite062009
protein dimerization activity	0.797229273848179	bayes_pls_golite062009
hormone receptor binding	0.74373733735458	bayes_pls_golite062009
promoter binding	0.58091332905515	bayes_pls_golite062009
protein N-terminus binding	0.57701453824007	bayes_pls_golite062009
thyroid hormone receptor activity	0.49784404390361	bayes_pls_golite062009
protein heterodimerization activity	0.45265806678057	bayes_pls_golite062009
receptor binding	0.418843034756825	bayes_pls_golite062009
ligand-regulated transcription factor activity	0.202197503742221	bayes_pls_golite062009
lipid binding	0.164046651023989	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.15737167800277	bayes_pls_golite062009
catalytic activity	0.106902059021677	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..126]	PSI-BLAST	23.69897	Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
2	View Details	[127..463]	PSI-BLAST	30.69897	Pregnane x receptor, PXR

Protein Overview: nhr-3

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: