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Protein Overview: mec-18

General Information:
Name(s) found: mec-18 / CE16940 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00003179 locus:mec-18 status:Partially_confirmed UniProt:O45873 protein_id:CCD65418.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 638 amino acids

    Gene Ontology:
    Cellular Component: cell [IDALink to PubMed article]
    Biological Process: propionate catabolic process, 2-methylcitrate cycle [IEALink to PubMed article]
    teichoic acid biosynthetic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    menaquinone biosynthetic process [IEALink to PubMed article]
    detection of mechanical stimulus involved in sensory perception of touch [IMPLink to PubMed article]
    siderophore biosynthetic process [IEALink to PubMed article]
    Molecular Function: D-alanine-poly(phosphoribitol) ligase activity [IEALink to PubMed article]
    CoA-ligase activity [TAS]
    AMP binding [IEALink to PubMed article]
    acetate-CoA ligase activity [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    propionate-CoA ligase activity [IEALink to PubMed article]
    o-succinylbenzoate-CoA ligase activity [IEALink to PubMed article]
    (2,3-dihydroxybenzoyl)adenylate synthase activity [IEALink to PubMed article]
    ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIQNPFQIS WDKTAAQSFH DYFFSKISAH GSNLAIVDVD SGKQWRYSEI RNWCEMCATR  60
   61 LKELQVTSGS RVAVITGTTG QAIFVHLACS IIGCSAVAVN GWNAVDEIWT LVDLSEATHL 120
  121 IVENQFMQKA DDVRRKAQMR GGGRIKHVRQ IEDVLTAERI NVDSARKRSI DVKQKPPLVK 180
  181 EMSLAKINLT PVLPEDIADL TSPVSEVSGQ SKELNGDVES SVVDSEEVQT PIQQVSGQNP 240
  241 LLILFTSGTT GLAKAAELSH RSLIINIQQI SLPLYGPVQT KERFLLPLSI AHIYGIVSAY 300
  301 YALINGASLY LISKQSNRLF METLVNNQIN VMHITPAIVH WMATDAIVDD YKTPNLRSVL 360
  361 CAGAPIDSNS AAAMKSRLNI KDFRQSFGMT ELGGICTMSP YLDEKIESVG NPLPGMLFKV 420
  421 VNWETKQLCL PRQPGQIIVL GPQVSPCYYK NPKATSELFD ATGFVKTGDA GFYDEVGRIY 480
  481 VLDRIKDIIK CKGTMICPSE VELVLRAHAG IDDCAVVGRQ DHVTGEVPAA FVVKNAQHPL 540
  541 LASAEVRQYV SGKIATFKEL RGGVFFISEI PRSVCGKILR RNLRQFWDRE RTNSKVDSLT 600
  601 NKDGAKTAGA AKGAPAKKVN GSTTPSRRPP SAGRPVKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..638] PSI-BLAST 96.39794 FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-sulfur bonds
    		•  5.10123876514454 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  4.28278725989432 bayes_pls_golite062009
  • CoA-ligase activity
    		•  4.12850865352867 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  3.83959707137518 bayes_pls_golite062009
  • fatty acid ligase activity
    		•  3.10420612952117 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  2.84227244567785 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.464663038956639 bayes_pls_golite062009
  • binding
    		•  0.430808312294251 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.32

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle