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View Structure Prediction Details

Protein: mec-18
Organism: Caenorhabditis elegans
Length: 638 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mec-18.

Description E-value Query
Range
Subject
Range
gi|75701558, gi|... - gi|75907833|ref|YP_322129.1| amino acid adenylation [Anabaena variabilis ATCC 29413], gi|75701558|gb...
535.0 [0..37] [638..480]

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Predicted Domain #1
Region A:
Residues: [1-638]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIQNPFQIS WDKTAAQSFH DYFFSKISAH GSNLAIVDVD SGKQWRYSEI RNWCEMCATR  60
   61 LKELQVTSGS RVAVITGTTG QAIFVHLACS IIGCSAVAVN GWNAVDEIWT LVDLSEATHL 120
  121 IVENQFMQKA DDVRRKAQMR GGGRIKHVRQ IEDVLTAERI NVDSARKRSI DVKQKPPLVK 180
  181 EMSLAKINLT PVLPEDIADL TSPVSEVSGQ SKELNGDVES SVVDSEEVQT PIQQVSGQNP 240
  241 LLILFTSGTT GLAKAAELSH RSLIINIQQI SLPLYGPVQT KERFLLPLSI AHIYGIVSAY 300
  301 YALINGASLY LISKQSNRLF METLVNNQIN VMHITPAIVH WMATDAIVDD YKTPNLRSVL 360
  361 CAGAPIDSNS AAAMKSRLNI KDFRQSFGMT ELGGICTMSP YLDEKIESVG NPLPGMLFKV 420
  421 VNWETKQLCL PRQPGQIIVL GPQVSPCYYK NPKATSELFD ATGFVKTGDA GFYDEVGRIY 480
  481 VLDRIKDIIK CKGTMICPSE VELVLRAHAG IDDCAVVGRQ DHVTGEVPAA FVVKNAQHPL 540
  541 LASAEVRQYV SGKIATFKEL RGGVFFISEI PRSVCGKILR RNLRQFWDRE RTNSKVDSLT 600
  601 NKDGAKTAGA AKGAPAKKVN GSTTPSRRPP SAGRPVKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 96.39794
Match: 1ba3A
Description: FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming carbon-sulfur bonds 5.10123876514454 bayes_pls_golite062009
acid-thiol ligase activity 4.28278725989432 bayes_pls_golite062009
CoA-ligase activity 4.12850865352867 bayes_pls_golite062009
acetate-CoA ligase activity 3.83959707137518 bayes_pls_golite062009
fatty acid ligase activity 3.10420612952117 bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity 2.84227244567785 bayes_pls_golite062009
ligase activity 2.49556073715112 bayes_pls_golite062009
catalytic activity 1.83545185797733 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.464663038956639 bayes_pls_golite062009
binding 0.430808312294251 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle