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Protein Overview: alh-5

General Information:
Name(s) found: alh-5 / CE13415 [WormBase]
Description(s) found:
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  • WBGene00000111 locus:alh-5 Aldehyde dehydrogenase status:Confirmed UniProt:O44555 protein_id:CCD72111.1 [WormBase]
  • pir||T30897 hypothetical protein T08B1.3 - Caenorhabditis elegans [NCBI NR]
  • gi|2736371|gb|AAB94178.1| Aldehyde dehydrogenase protein 5 [Caenorhabditis elegans] [NCBI NR]
  • gi|17564084|ref|NP_503545.1| ALdehyde deHydrogenase family member (alh-5) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE13415 WBGene00000111 locus:alh-5 aldehyde dehydrogenase status:Confirmed TR:O44555 protein_id:AAB94178.1 [wormpep150.fasta]
  • 13415 WBGene00000111 locus:alh-5 aldehyde dehydrogenase status:Confirmed TR:O44555 protein_id:AAB94178.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • ALDH3C2, ALdehyde deHydrogenase (48.8 kD) (alh-5) [Caenorhabditis elegans]gi|2736371|gb|AAB94178.1| Aldehyde dehydrogenase protein 5 [Caenorhabditis elegans]gi|7507434|pir||T30897 hypothetical protein T08B1.3 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:alh-5 aldehyde dehydrogenase status:Confirmed TR:O44555 protein_id:AAB94178.1 [wormpep115.fasta.reversed]
  • CE13415 aldehyde dehydrogenase status:Confirmed TR:O44555 protein_id:AAB94178.1 [wormpep80.hongbin]
  • CE13415 WBGene00000111 locus:alh-5 aldehyde dehydrogenase status:Confirmed UniProt:O44555_CAEEL protein_id:AAB94178.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE13415 WBGene00000111 locus:alh-5 aldehyde dehydrogenase status:Confirmed UniProt:O44555_CAEEL protein_id:AAB94178.1| [wormORF-contam.fasta]
  • ALdehyde deHydrogenase family member (alh-5) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Aldehyde dehydrogenase protein 5 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE13415 WBGene00000111 locus:alh-5 aldehyde dehydrogenase status:Confirmed UniProt:O44555 protein_id:AAB94178.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE13415 WBGene00000111 locus:alh-5 aldehyde dehydrogenase status:Confirmed UniProt:O44555 protein_id:CCD72111.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE13415 WBGene00000111 locus:alh-5 status:Confirmed UniProt:O44555 protein_id:CCD72111.1 Aldehyde dehydrogenase [wormpep246-ecoli-contam.fasta]
  • Aldehyde dehydrogenase OS=Caenorhabditis elegans GN=alh-5 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 437 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IEALink to PubMed article]
    Biological Process: cellular aldehyde metabolic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    proline biosynthetic process [IEALink to PubMed article]
    valine metabolic process [IEALink to PubMed article]
    betaine biosynthetic process [IEALink to PubMed article]
    Molecular Function: 1-pyrroline-5-carboxylate dehydrogenase activity [IEALink to PubMed article]
    betaine-aldehyde dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    aldehyde dehydrogenase [NAD(P)+] activity [IEALink to PubMed article]
    methylmalonate-semialdehyde dehydrogenase (acylating) activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLHRIVEAQ RAYFNTGATK PAEFRKEQLL QLKKLIEENR AALTEVVWKD LRRRHEVTEP  60
   61 MELGGSLEEI AYYLKNLDDW MKPTYVEPTV ATLPTDKPYI VKDPKGVVLV ISPWNYPVSM 120
  121 VLLPMIPSIA AGNTIVIKPS ELSENTAILF EKLIPKYFDP KYVTIVNGGI PETTELLKER 180
  181 FDHIIYTGCP PVAKIIMAAA AKHLTPVTLE LGGKCPVVVE DDADIEISAQ RIARGKWLNC 240
  241 GQTCLAPDYI LVSSATKPKF VAAIQKCLKE FYGGNAKESK DYSRVINQRH FDRISALLDE 300
  301 SKGVVLAGNE ESRDRSDRFI PPTVLDVEKT DPFMHDEIFG PVLPIITVKN LCESIDFINK 360
  361 GEKPLAAYIF TKDEAKVQRF LNETTSGGVT VNDVIMHVAV ITLPFGGVGV SGMGRYRGKF 420
  421 GFDTFTHEKS VLQRVFA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..437] PSI-BLAST 108.0 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  4.34495776828926 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  2.6673036327943 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  1.59279206536309 bayes_pls_golite062009
  • binding
    		•  1.06673666884196 bayes_pls_golite062009
  • protein binding
    		•  0.894945263794726 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  0.882678635212924 bayes_pls_golite062009
  • electron carrier activity
    		•  0.869224905025397 bayes_pls_golite062009
  • hydrolase activity
    		•  0.352374326884796 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.258030369394064 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle