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Protein Overview: tkt-1

General Information:
Name(s) found: tkt-1 / CE09163 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00008506 locus:tkt-1 status:Confirmed UniProt:O17759 protein_id:CAB02889.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 618 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    terpenoid biosynthetic process [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: aldehyde-lyase activity [IEALink to PubMed article]
    thiamin pyrophosphate binding [IEALink to PubMed article]
    1-deoxy-D-xylulose-5-phosphate synthase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    transketolase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVSEQLRND LEDAANRMRI SSIEMTCASK SGHPTSSTSA AEIMSTLFFS EMKYDVAEPK  60
   61 SASADRFVLS KGHACPILYA AWEEAGLLSH EQVLSLRKID SDIEGHPTPR LNFIDVATGS 120
  121 LGQGLGVATG MAYVGKYIDK ASYRVFCLLG DGESAEGSVW EAAAFASIYK LDNLVAIVDV 180
  181 NRLGQSQATS LGHDVETYKA RFAAFGFNAI IVNGHNVDEL LAAYETARST KGKPTAIIAK 240
  241 TLKGKGIEGI ENEDNWHGKP VPEGTVNAIK ARFHGSQKGK LVAQKPINDA PAIDLHVGSI 300
  301 KMAAPEYKKG DKVATRAAYG TALAKLGDAS PRVIGLDGDT KNSTFSDKLL KKHPDQFIEC 360
  361 FIAEQNLVGV AVGAQCRDRT IPFTSTFAAF FTRATDQIRM AAVSFANLKC VGSHVGVSIG 420
  421 EDGPSQMALE DLAIFRTIPG ATVFYPTDAV SAERATELAA NTKGVVFIRT GRPALPVLYD 480
  481 NEEPFHIGQA KVVKQSAQDK IVLVGSGVTL YESLKAAEEL EKEGIHATVI DPFTIKPLDG 540
  541 KTIAEHALKV GGRVVTTEDH YAAGGIGEAV SAALADYPTI RVRSLNVKEV PRSGPPDALV 600
  601 DMYGISARHI VAAVKNFQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..618] PSI-BLAST 170.0 Transketolase (TK), Pyr module; Transketolase (TK), PP module; Transketolase (TK), C-domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transketolase activity
    		•  6.17852985073866 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  2.93250853993668 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  2.81702263447118 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  2.6977837113283 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.21959520697519 bayes_pls_golite062009
  • binding
    		•  0.551586872853971 bayes_pls_golite062009
  • catalytic activity
    		•  0.545407789079971 bayes_pls_golite062009
  • thiamin pyrophosphate binding
    		•  0.297191393111081 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  0.173822256668691 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle