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Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate. Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA = vanillin + acetyl-CoA. Catalysis of the reaction: 2-dehydro-3-deoxy-D-pentonate = glycolaldehyde + pyruvate. Catalysis of the reaction: 5-dehydro-2-deoxy-D-gluconate 6-phosphate = malonate semialdehyde + dihydroxy-acetone-phosphate. Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. Catalysis of the reaction: D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate. Catalysis of the reaction: L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate. Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde. Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = desmosterol + acetaldehyde. Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O. Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde. Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde. Catalysis of the reaction: erythrulose 1-phosphate = glycerone phosphate + formaldehyde. Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate. Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate. Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde. Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. Catalysis of the reaction: L-threo-3-phenylserine = glycine + benzaldehyde. Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde. Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde. Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone. Catalysis of the reaction: (S)-lactate = formate + acetaldehyde. Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. Catalysis of the reaction: (CH3)3NO = (CH3)2NH + formaldehyde. Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. Catalysis of the reaction: 2 propanal = 4-hydroxy-3-hexanone. Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. Catalysis of the reaction: benzoin = 2 benzaldehyde. Catalysis of the reaction: L-threonine = glycine + acetaldehyde. Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate. Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: aldehyde-lyase activity
Acc: GO:0016832
Aspect: Molecular Function
Desc: Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
Synonyms:
  • GO:0016228
  • aldolase activity
Proteins in PDR annotated with:
   This term: 25 [Search]
   Term or descendants: 141 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016832 - aldehyde-lyase activity (interactive image map)
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Created and Maintained by: Michael Riffle