General Information: |
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Name(s) found: |
hda-1 /
CE08952
[WormBase]
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Description(s) found:
SHOW ONLY BEST |
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Organism: | Caenorhabditis elegans |
Length: | 461 amino acids |
Gene Ontology: |
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Cellular Component: |
female germ cell nucleus
[IDA]
nucleus [IDA] cytoplasm [IDA] NuRD complex [IPI] histone deacetylase complex [IPI] |
Biological Process: |
negative regulation of vulval development
[IGI][IMP]
DNA repair [IMP] hermaphrodite genitalia development [IMP] embryonic development ending in birth or egg hatching [IMP] embryonic digestive tract morphogenesis [IGI] gamete generation [IMP] negative regulation of Notch signaling pathway [IMP] reproduction [IMP] negative regulation of transcription from RNA polymerase II promoter [IMP] negative regulation of Ras protein signal transduction [IGI] gonad development [IMP] regulation of cell differentiation [IGI] histone deacetylation [IDA] |
Molecular Function: |
histone deacetylase activity
[IDA]
transcription corepressor activity [IPI] |
Sequence: |
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Sequence: [PDR BLAST] [ProtParam] |
1 11 21 31 41 51 | | | | | | 1 MNSNGPLMEH GKRRVAYYYD SNIGNYYYGQ GHVMKPHRIR MTHHLVLNYG LYRNLEIFRP 60 61 FPASFEDMTR FHSDEYMTFL KSANPDNLKS FNKQMLKFNV GEDCPLFDGL YEFCQLSSGG 120 121 SLAAATKLNK QKVDIAINWM GGLHHAKKSE ASGFCYTNDI VLGILELLKY HKRVLYVDID 180 181 VHHGDGVEEA FYTTDRVMTV SFHKYGDFFP GTGDLKDIGA GKGKLYSVNV PLRDGITDVS 240 241 YQSIFKPIMT KVMERFDPCA VVLQCGADSL NGDRLGPFNL TLKGHGECAR FFRSYNVPLM 300 301 MVGGGGYTPR NVARCWTYET SIAVDKEVPN ELPYNDYFEY FGPNYRLHIE SSNAANENSS 360 361 DMLAKLQTDV IANLEQLTFV PSVQMRPIPE DALSALNDDS LIADQANPDK RLPPQITDGM 420 421 IQDDGDFYDG EREGDDRRNE SDAKRAAQFE SEGGEKRQKT E |
The following runs contain data for this protein:
  | BAIT | COMMENTS | PUBLICATION |
View Run | hcp1 IP from december2004 | Cheeseman, I.M., et al. (2005) |
NOT SHOWING SINGLE HITS. [ Show Single Hits ]
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Domains predicted:
# | Region(s) | Method | Confidence | Match Description | |
1 | View Details | [1..388] | 94.0 | Crystal Structure of human HDAC8 complexed with Trichostatin A | |
2 | View Details | [389..461] | 1.097991 | View MSA. No confident structure predictions are available. |
Functions predicted (by domain):
# | Gene Ontology predictions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 |
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2 | No functions predicted. |
Protein predicted to be: | GLOBULAR (No transmembrane regions or signal peptide) |
Confidence of classification: | 0.99 |
Source: Reynolds et al. (2008)