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Protein Overview: hda-1

General Information:
Name(s) found: hda-1 / CE08952 [WormBase]
Description(s) found:
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  • WBGene00001834 locus:hda-1 Histone deacetylase 1 status:Confirmed UniProt:O17695 protein_id:CAB03984.1 [WormBase]
  • pir||T20163 hypothetical protein C53A5.3 - Caenorhabditis elegans [NCBI NR]
  • gi|3875199|emb|CAB03984.1| C. elegans protein C53A5.3, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|3023926|sp|O17695.1|HDA1_CAEEL RecName: Full=Histone deacetylase 1 [NCBI NR]
  • gi|17561978|ref|NP_506599.1| Histone DeAcetylase family member (hda-1) [Caenorhabditis elegans] [NCBI NR]
  • Histone deacetylase 1 OS=Caenorhabditis elegans GN=hda-1 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE08952 WBGene00001834 locus:hda-1 Yeast RPD3 protein like status:Partially_confirmed SW:O17695 protein_id:CAB03984.1 [wormpep150.fasta]
  • 08952 WBGene00001834 locus:hda-1 Yeast RPD3 protein like status:Partially_confirmed SW:O17695 protein_id:CAB03984.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • histone deacetylase, abnormal GONad development GON-10 (52.1 kD) (hda-1) [Caenorhabditis elegans]gi|3875199|emb|CAB03984.1| Hypothetical protein C53A5.3 [Caenorhabditis elegans]gi|7497847|pir||T20163 hypothetical protein C53A5.3 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:hda-1 Yeast RPD3 protein like status:Partially_confirmed SW:O17695 protein_id:CAB03984.1 [wormpep115.fasta.reversed]
  • CE08952 locus:hda-1 Yeast RPD3 protein like status:Partially_confirmed SW:O17695 protein_id:CAB03984.1 [wormpep80.hongbin]
  • CE08952 WBGene00001834 locus:hda-1 Yeast RPD3 protein like status:Confirmed UniProt:O17695 protein_id:CAB03984.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE08952 WBGene00001834 locus:hda-1 Yeast RPD3 protein like status:Confirmed UniProt:O17695 protein_id:CAB03984.1| [wormORF-contam.fasta]
  • Histone deacetylase 1 [nr-271106-contam.fasta]
  • Hypothetical protein C53A5.3 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Histone DeAcetylase family member (hda-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE08952 WBGene00001834 locus:hda-1 Yeast RPD3 protein like status:Confirmed SW:O17695 protein_id:CAB03984.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE08952 WBGene00001834 locus:hda-1 status:Confirmed UniProt:O17695 protein_id:CAB03984.1 Histone deacetylase 1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 461 amino acids

    Gene Ontology:
    Cellular Component: female germ cell nucleus [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    NuRD complex [IPILink to PubMed article]
    histone deacetylase complex [IPILink to PubMed article]
    Biological Process: negative regulation of vulval development [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    DNA repair [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic digestive tract morphogenesis [IGILink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    negative regulation of Notch signaling pathway [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed articleLink to PubMed article]
    negative regulation of Ras protein signal transduction [IGILink to PubMed articleLink to PubMed article]
    gonad development [IMPLink to PubMed article]
    regulation of cell differentiation [IGILink to PubMed article]
    histone deacetylation [IDALink to PubMed article]
    Molecular Function: histone deacetylase activity [IDALink to PubMed article]
    transcription corepressor activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNGPLMEH GKRRVAYYYD SNIGNYYYGQ GHVMKPHRIR MTHHLVLNYG LYRNLEIFRP  60
   61 FPASFEDMTR FHSDEYMTFL KSANPDNLKS FNKQMLKFNV GEDCPLFDGL YEFCQLSSGG 120
  121 SLAAATKLNK QKVDIAINWM GGLHHAKKSE ASGFCYTNDI VLGILELLKY HKRVLYVDID 180
  181 VHHGDGVEEA FYTTDRVMTV SFHKYGDFFP GTGDLKDIGA GKGKLYSVNV PLRDGITDVS 240
  241 YQSIFKPIMT KVMERFDPCA VVLQCGADSL NGDRLGPFNL TLKGHGECAR FFRSYNVPLM 300
  301 MVGGGGYTPR NVARCWTYET SIAVDKEVPN ELPYNDYFEY FGPNYRLHIE SSNAANENSS 360
  361 DMLAKLQTDV IANLEQLTFV PSVQMRPIPE DALSALNDDS LIADQANPDK RLPPQITDGM 420
  421 IQDDGDFYDG EREGDDRRNE SDAKRAAQFE SEGGEKRQKT E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..388] PSI-BLAST 94.0 Crystal Structure of human HDAC8 complexed with Trichostatin A
    2 View Details [389..461] MSA 1.097991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  12.8220438463909 bayes_pls_golite062009
  • histone deacetylase activity
    		•  12.6231784270509 bayes_pls_golite062009
  • deacetylase activity
    		•  11.5037545953213 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  9.39837596691907 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  9.35288901670927 bayes_pls_golite062009
  • histone deacetylase activity (H3-K16 specific)
    		•  6.99181745976945 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  4.16874113003585 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K27 specific)
    		•  3.8227021325477 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.65015413158247 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.49362347258099 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05701986980927 bayes_pls_golite062009
  • transcription factor binding
    		•  2.19991964087943 bayes_pls_golite062009
  • hydrolase activity
    		•  2.17916401684365 bayes_pls_golite062009
  • NAD-independent histone deacetylase activity
    		•  2.1026758793482 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09632179671955 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.98907367314887 bayes_pls_golite062009
  • DNA binding
    		•  1.982290944939 bayes_pls_golite062009
  • binding
    		•  1.948738669065 bayes_pls_golite062009
  • protein binding
    		•  1.77599011146146 bayes_pls_golite062009
  • catalytic activity
    		•  1.68836803454021 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  1.48241147541212 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  1.37118634909958 bayes_pls_golite062009
  • transcription activator activity
    		•  1.31578100431097 bayes_pls_golite062009
  • transcription factor activity
    		•  1.24596588472933 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84972377395539 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.396822865624511 bayes_pls_golite062009
  • transferase activity
    		•  0.323230424038105 bayes_pls_golite062009
  • chromatin binding
    		•  0.104097933861351 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle