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Protein Overview: hsp-4

General Information:
Name(s) found: hsp-4 / CE07244 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00002008 locus:hsp-4 Heat shock 70 kDa protein D status:Partially_confirmed UniProt:P20163 protein_id:CCD63548.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 657 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEALink to PubMed article][ISSLink to PubMed article]
    Biological Process: embryonic development [IMPLink to PubMed article]
    endoplasmic reticulum unfolded protein response [IEPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    cell morphogenesis [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    protein folding [IEALink to PubMed article][ISSLink to PubMed article]
    response to stress [IDALink to PubMed article][ISSLink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    iron-sulfur cluster assembly [IEALink to PubMed article]
    Molecular Function: ATPase activity [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    unfolded protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVFSLILIA FVANAYCDEG ASTEKEEKMG TIIGIDLGTT YSCVGVFKNG RVEIIANDQG  60
   61 NRITPSYVAF SGDQGERLIG DAAKNQLTIN PENTIFDAKR LIGRFYNEKT VQQDIKHWPF 120
  121 KIVDKSNKPN VEVKVGSETK QFTPEEVSAM VLTKMKQIAE SYLGHEVKNA VVTVPAYFND 180
  181 AQKQATKDAG SIAGLNVVRI INEPTAAAIA YGLDKKDGER NILVFDLGGG TFDVSLLTID 240
  241 SGVFEVLATN GDTHLGGEDF DQRVMEYFIK LYKKKSGKDL RKDNRAVQKL RREVEKAKRA 300
  301 LSTQHQTKIE IESLFDGEDF SETLTRAKFE ELNMDLFRAT LKPVQKVLED ADMKKTDVHE 360
  361 IVLVGGSTRI PKVQQLIKDY FNGKEPSRGI NPDEAVAYGA AVQAGVIGGV ENTGDVVLLD 420
  421 VNPLTLGIET VGGVMTKLIG RNTVIPTKKS QVFSTAADSQ SAVSIVIYEG ERPMVMDNHK 480
  481 LGNFDVTGIP PAPRGVPQIE VTFEIDVNGI LHVSAEDKGT GNKNKLTITN DHNRLSPEDI 540
  541 ERMINDADKF AADDQAQKEK VESRNELEAY AYQMKTQIAD KEKLGGKLTD EDKVSIESAV 600
  601 ERAIEWLGSN QDASTEENKE QKKELESVVQ PIVSKLYSAG GQGEQASEEP SEDHDEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run knl-1 No Comments Cheeseman, I.M., et al. (2004)
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..587] PSI-BLAST 1000.0 crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
    2 View Details [588..657] PSI-BLAST 54.221849 DnaK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.97191512372019 bayes_pls_golite062009
  • structural molecule activity
    		•  3.59589495899762 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.46121037473545 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20983242331685 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • hydrolase activity
    		•  1.88613511243568 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68670098354938 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.43834016708999 bayes_pls_golite062009
  • peptidase activity
    		•  1.4127499531612 bayes_pls_golite062009
  • DNA binding
    		•  1.36804228074586 bayes_pls_golite062009
  • transporter activity
    		•  1.2883466875237 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.16749728168925 bayes_pls_golite062009
  • kinase activity
    		•  1.11102445353265 bayes_pls_golite062009
  • actin binding
    		•  1.03829083423378 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.953663805249074 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.900931843471417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.898645342556399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.875671218597808 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.796517590178929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.783439770973386 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.78242344952806 bayes_pls_golite062009
  • protein transporter activity
    		•  0.780308299678282 bayes_pls_golite062009
  • ATPase activity
    		•  0.687771333492666 bayes_pls_golite062009
  • myosin binding
    		•  0.607451856096 bayes_pls_golite062009
  • glucose binding
    		•  0.53527958884988 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.186218331473028 bayes_pls_golite062009
  • chromatin binding
    		•  0.155140608043269 bayes_pls_golite062009
  • protease binding
    		•  0.121259015422625 bayes_pls_golite062009
  • chaperone binding
    		•  0.00111313452804307 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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