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Protein Overview: trs-1

General Information:
Name(s) found: trs-1 / CE05434 [WormBase]
Description(s) found:
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  • WBGene00006617 locus:tars-1 Threonine--tRNA ligase, cytoplasmic status:Confirmed UniProt:P52709 protein_id:CAA93762.1 [WormBase]
  • pir||T19994 hypothetical protein C47D12.6 - Caenorhabditis elegans [NCBI NR]
  • gi|71984184|ref|NP_001022033.1| Threonyl tRNA Synthetase family member (trs-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|3875006|emb|CAA93762.1| C. elegans protein C47D12.6a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_496497.1| threonyl tRNA Synthetase (84.4 kD) (trs-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|1711653|sp|P52709.1|SYTC_CAEEL RecName: Full=Threonyl-tRNA synthetase, cytoplasmic; AltName: Full=Threonine--tRNA ligase; Short=ThrRS [NCBI NR]
  • (P52709) Threonyl-tRNA synthetase, cytoplasmic (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) [Swiss-Prot]
  • Threonine--tRNA ligase, cytoplasmic OS=Caenorhabditis elegans GN=trs-1 PE=3 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE05434 WBGene00006617 locus:trs-1 threonyl-tRNA synthetase (mitochondrial) status:Confirmed SW:P52709 protein_id:CAA93762.1 [wormpep150.fasta]
  • 05434 WBGene00006617 locus:trs-1 threonyl-tRNA synthetase (mitochondrial) status:Confirmed SW:P52709 protein_id:CAA93762.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • threonyl tRNA Synthetase (84.4 kD) (trs-1) [Caenorhabditis elegans]gi|3875006|emb|CAA93762.1| Hypothetical protein C47D12.6a [Caenorhabditis elegans]gi|7497557|pir||T19994 hypothetical protein C47D12.6 - Caenorhabditis elegansgi|1711653|sp|P52709|SYT_C [nrdb_11152004_Chlamydomonas]
  • locus:trs-1 threonyl-tRNA synthetase (mitochondrial) status:Partially_confirmed SW:P52709 protein_id:CAA93762.1 [wormpep115.fasta.reversed]
  • CE05434 locus:trs-1 threonyl-tRNA synthetase status:Partially_confirmed SW:P52709 protein_id:CAA93762.1 [wormpep80.hongbin]
  • CE05434 WBGene00006617 locus:trs-1 threonyl-tRNA synthetase (mitochondrial) status:Confirmed UniProt:SYTC_CAEEL protein_id:CAA93762.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE05434 WBGene00006617 locus:trs-1 threonyl-tRNA synthetase (mitochondrial) status:Confirmed UniProt:SYTC_CAEEL protein_id:CAA93762.1| [wormORF-contam.fasta]
  • Threonyl tRNA Synthetase family member (trs-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Threonyl-tRNA synthetase, cytoplasmic (Threonine--tRNA ligase) (ThrRS) [nr-271106-contam.fasta]
  • Hypothetical protein C47D12.6a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE05434 WBGene00006617 locus:trs-1 threonyl-tRNA synthetase (mitochondrial) status:Confirmed UniProt:P52709 protein_id:CAA93762.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE05434 WBGene00006617 locus:tars-1 threonyl-tRNA synthetase (mitochondrial) status:Confirmed UniProt:P52709 protein_id:CAA93762.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE05434 WBGene00006617 locus:tars-1 status:Confirmed UniProt:P52709 protein_id:CAA93762.1 Threonine--tRNA ligase, cytoplasmic [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 725 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: tRNA aminoacylation for protein translation [IEALink to PubMed article]
    glycyl-tRNA aminoacylation [IEALink to PubMed article]
    histidyl-tRNA aminoacylation [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    threonyl-tRNA aminoacylation [IEALink to PubMed article]
    prolyl-tRNA aminoacylation [IEALink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    translation [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    histidine-tRNA ligase activity [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    glycine-tRNA ligase activity [IEALink to PubMed article]
    aminoacyl-tRNA ligase activity [IEALink to PubMed article]
    proline-tRNA ligase activity [IEALink to PubMed article]
    threonine-tRNA ligase activity [IEALink to PubMed article]
    serine-type carboxypeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLNCFRIFV HIQKPTQIFK PFYRSLSSEA SDKYHFVNGH KMSKAPTDMA PWPAFIEERI  60
   61 KLWDKLKAEY DAEIAAKESE PIQITLPDGK IHEGKTWRTT PFEIAERISK GLAEAAVIAK 120
  121 VNGAVWDLDR PFEGNAKLEL LKFDDDEAKQ VFWHSSAHVL GEAMERYCGG HLCYGPPIQE 180
  181 GFYYDMWHEN RTICPDDFPK IDQIVKAAVK DKQKFERLEM TKEDLLEMFK YNEFKVRIIT 240
  241 EKIHTPKTTV YRCGPLIDLC RGPHVRHTGK VKAMAITKNS SSYWEGKADA ESLQRLYGIS 300
  301 FPDSKQLKEW QKLQEEAAKR DHRKLGKEHD LFFFHQLSPG SAFWYPKGAH IYNKLVDFIR 360
  361 KQYRRRGFTE VITPNMYNKK LWETSGHWQH YSEDMFKIEV EKEEFGLKPM NCPGHCLMFG 420
  421 HMPHTYNELP FRFADFGVLH RNEMSGALTG LTRVRRFQQD DAHIFCRQDQ ISEEIKQCLD 480
  481 FLEYAYEKVF GFTFKLNLST RPEGFLGNIE TWDKAEADLT NALNASGRKW VLNPGDGAFY 540
  541 GPKIDITIQD ALKRNFQCAT IQLDFQLPNQ FDLSYFDEKG EKQRPVMIHR AVLGSVERMT 600
  601 AILTESYGGK WPFWLSPRQC KIITVHESVR DYANDVKKQI FEAGFEIEYE ENCGDTMNKQ 660
  661 VRKAQLAQFN FILVIGAKEK ENGTVNVRTR DNAVRGEVAL DKLISKFRRF ADEYVADTEK 720
  721 SEEWA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] PSI-BLAST 3.39794 Crystal structure of the bifunctional catalytic fragment of RelSeq, the RelA/SpoT homolog from Streptococcus equisimilis.
    2 View Details [81..725] PSI-BLAST 151.0 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity, transferring phosphorus-containing groups
    		•  1.87905122835689 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.54766964052089 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.28424599869932 bayes_pls_golite062009
  • transferase activity
    		•  1.1355378442847 bayes_pls_golite062009
  • binding
    		•  1.05159429628737 bayes_pls_golite062009
  • DNA binding
    		•  1.00266449873436 bayes_pls_golite062009
  • catalytic activity
    		•  0.75232920999699 bayes_pls_golite062009
  • protein binding
    		•  0.117945573723438 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  6.47381405106149 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  2.99105702052936 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • binding
    		•  1.11470390774037 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.0753492604686 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.897558352141977 bayes_pls_golite062009
  • DNA binding
    		•  0.854148126675211 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.55217603492525 bayes_pls_golite062009
  • transcription factor activity
    		•  0.283508546234551 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle