Protein Overview: vha-18

General Information:
Name(s) found:	vha-18 / CE04638 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00018698 locus:vha-18 Probable V-type proton ATPase subunit H 1 status:Confirmed UniProt:Q20666 protein_id:CCD70812.1 [WormBase] pir\|\|F89130 protein F52E1.10 [imported] - Caenorhabditis elegans [NCBI NR] gi\|17561240\|ref\|NP_505171.1\| Vacuolar H ATPase family member (vha-18) [Caenorhabditis elegans] [NCBI NR] gi\|12585452\|sp\|Q20666.1\|VATH1_CAEEL RecName: Full=Probable V-type proton ATPase subunit H 1; Short=V-ATPase subunit H 1; AltName: Full=Vacuolar proton pump subunit H 1 [NCBI NR] gi\|1086810\|gb\|AAB37043.1\| Hypothetical protein F52E1.10 [Caenorhabditis elegans] [NCBI NR] Probable V-type proton ATPase subunit H 1 OS=Caenorhabditis elegans GN=vha-18 PE=3 SV=1 [Swiss-Prot] (Q20666) Probable vacuolar ATP synthase subunit H 1 (EC 3.6.3.14) (V-ATPase H subunit 1) (Vacuolar proton pump H subunit 1) (Vacuolar proton pump subunit SFD 1) [Swiss-Prot] [wormpep67.fasta] CE04638 WBGene00018698 ATPase status:Partially_confirmed SW:Q20666 protein_id:AAB37043.1 [wormpep150.fasta] 04638 WBGene00018698 ATPase status:Partially_confirmed SW:Q20666 protein_id:AAB37043.1 [wormpep130-phg-ecoli-orf-rand.fasta] vacuolar atp synthase (52.4 kD) (5I892) [Caenorhabditis elegans]gi\|1086810\|gb\|AAB37043.1\| Hypothetical protein F52E1.10 [Caenorhabditis elegans]gi\|25375104\|pir\|\|F89130 protein F52E1.10 [imported] - Caenorhabditis elegansgi\|12585452\|sp\|Q20666\|VAH1_CAEEL [nrdb_11152004_Chlamydomonas] ATPase status:Partially_confirmed SW:Q20666 protein_id:AAB37043.1 [wormpep115.fasta.reversed] CE04638 ATPase status:Partially_confirmed SW:Q20666 protein_id:AAB37043.1 [wormpep80.hongbin] CE04638 WBGene00018698 locus:vha-18 ATPase status:Partially_confirmed UniProt:VATH1_CAEEL protein_id:AAB37043.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE04638 WBGene00018698 locus:vha-18 ATPase status:Partially_confirmed UniProt:VATH1_CAEEL protein_id:AAB37043.1\| [wormORF-contam.fasta] Hypothetical protein F52E1.10 [Caenorhabditis elegans] [nr-271106-contam.fasta] F52E1.10 [Caenorhabditis elegans] [nr-271106-contam.fasta] Probable vacuolar ATP synthase subunit H 1 (V-ATPase H subunit 1) (Vacuolar proton pump subunit H 1) [nr-271106-contam.fasta] CE04638 WBGene00018698 locus:vha-18 ATPase status:Partially_confirmed SW:Q20666 protein_id:AAB37043.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta] CE04638 WBGene00018698 locus:vha-18 ATPase status:Partially_confirmed UniProt:Q20666 protein_id:AAB37043.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE04638 WBGene00018698 locus:vha-18 ATPase status:Confirmed UniProt:Q20666 protein_id:CCD70812.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE04638 WBGene00018698 locus:vha-18 status:Confirmed UniProt:Q20666 protein_id:CCD70812.1 Probable V-type proton ATPase subunit H 1 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	451 amino acids
Gene Ontology:
Cellular Component:	vacuolar proton-transporting V-type ATPase, V1 domain [IEA] peripheral to membrane of membrane fraction [IEA]
Biological Process:	ATP synthesis coupled proton transport [IEA]
Molecular Function:	ATP binding [IEA] proton-transporting ATPase activity, rotational mechanism [IEA] hydrogen ion transporting ATP synthase activity, rotational mechanism [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFGENQDLI RTHFQKEADK VRAMKTNWGL FTRTRMIAQS DYDFIVTYQQ AENEAERSTV  60
   61 LSVFKEKAVY AFVHLMSQIS KDDYVRYTLT LIDDMLREDV TRTIIFEDVA VLLKRSPFSF 120
  121 FMGLLHRQDQ YIVHITFSIL TKMAVFGNIK LSGDELDYCM GSLKEAMNRG TNNDYIVTAV 180
  181 RCMQTLFRFD PYRVSFVNIN GYDSLTHALY STRKCGFQIQ YQIIFCMWLL TFNGHAAEVA 240
  241 LSGNLIQTIS GILGNCQKEK VIRIVVSTLR NLITSNQDVY MKKQAALQMI QNRIPTKLDH 300
  301 LENRKFTDVD LVEDMVYLQT ELKKVVQVLT SFDEYENELR QGSLHWSPAH KCEVFWNENA 360
  361 HRLNDNRQEL LKLLVAMLEK SNDPLVLCVA AHDIGEFVRY YPRGKLKVEQ LGGKEAMMRL 420
  421 LTVKDPNVRY HALLAAQKLM INNWKDLGLE I

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

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Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
hydrogen ion transmembrane transporter activity	8.27793692177437	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	6.61991113486273	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	5.91856058767561	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	3.08652472111805	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.01705909078235	bayes_pls_golite062009
protein transporter activity	2.91465420196082	bayes_pls_golite062009
ion transmembrane transporter activity	2.62570967627286	bayes_pls_golite062009
cation transmembrane transporter activity	2.5665080711484	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
binding	2.4389817190572	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
clathrin binding	2.07672364145383	bayes_pls_golite062009
RNA binding	1.90677197622326	bayes_pls_golite062009
protein binding	1.63705839411934	bayes_pls_golite062009
cation-transporting ATPase activity	1.60849969922683	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
protein transmembrane transporter activity	1.02389895825558	bayes_pls_golite062009
hydrolase activity	0.528047226063932	bayes_pls_golite062009
nucleic acid binding	0.294257360897755	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
signal sequence binding	0.14931345687137	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	0.0949889863173228	bayes_pls_golite062009
signal transducer activity	0.0689818654521059	bayes_pls_golite062009
molecular transducer activity	0.0689818654521059	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..451]	PSI-BLAST	68.0	Regulatory subunit H of the V-type ATPase

Protein Overview: vha-18

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: