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Protein Overview: pcca-1

General Information:
Name(s) found: pcca-1 / CE04451 [WormBase]
Description(s) found:
Found 24 descriptions.
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  • WBGene00017864 locus:pcca-1 Propionyl-CoA carboxylase alpha chain, mitochondrial status:Confirmed UniProt:Q19842 protein_id:CCD67920.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 724 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    acetyl-CoA carboxylase complex [IEALink to PubMed article]
    Biological Process: sodium ion transport [IEALink to PubMed article]
    gluconeogenesis [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    peptidoglycan biosynthetic process [IEALink to PubMed article]
    protein modification process [IEALink to PubMed article]
    purine base biosynthetic process [IEALink to PubMed article]
    fatty acid biosynthetic process [IEALink to PubMed article]
    Molecular Function: oxaloacetate decarboxylase activity [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    D-alanine-D-alanine ligase activity [IEALink to PubMed article]
    acetyl-CoA carboxylase activity [IEALink to PubMed article]
    pyruvate carboxylase activity [IEALink to PubMed article]
    biotin binding [IEALink to PubMed article]
    ligase activity [IEALink to PubMed article]
    hydroxymethyl-, formyl- and related transferase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRAASSIRA VANRGLATAA VARPGVPLDE REGKEIYTTV GIDYNEPKFD KILIANRGEI  60
   61 ACRVIKTARA MGIKTVAVHS DVDSNSLHVK MADEAVCVGE APTAKSYLRA DRILQAVEDT 120
  121 GAQAVHPGYG FLSENTKFAA ELEKAGAKFI GPNSKAILDM GDKIHSKKIA TAARVSMIPG 180
  181 YDGEIADEDM CVKVSRDIGY PVMIKASAGG GGKGMRVAWN DKQAREGYRL SKQEAASSFG 240
  241 DDRMLVEKFI DNPRHIEMQV LCDKHGNALW LNERECSIQR RNQKVIEEAP SSFVPPEMRR 300
  301 KMGEQAVQLA KAVGYDSAGT VEFLVDSQRN FYFLEMNTRL QVEHPITECI TGIDIVQQML 360
  361 RVSYGHPLPI TQEQVPLNGW AFESRVYAED PYKGFGLPSV GRLSRYVEPK HVDGVRCDSG 420
  421 IREGSEISIY YDPLICKLVT HGDNREQALN RMQEALDNYV IRGVTHNIPL LRDIVQEKRF 480
  481 RTGDITTKYL PEVYPEGFQG TSLSPKEQDV VIAFASALNA RKLARANQFL NQNKQRSTHV 540
  541 ASFSKTYKFV SSLPVKEGER PTEHAVEVEF VEGSANKAQV RIGGKTVTIS GDLNLSHPVN 600
  601 SIEVDGEHIT TQIVGKRAGE ITVLYKGTPF KVKVLPEQAV KYLQYMKEKA KVDLSTVVLS 660
  661 PMPGAIKNVN VKPGDMVSEG QELVVMEAMK MQNSLHAGKT GRVKAVNVKV GATVDEGEVL 720
  721 VELE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..544] PSI-BLAST 139.0 No description for 2gpwA was found.
    2 View Details [545..647] deduced N/A No confident structure predictions are available.
    3 View Details [648..724] PSI-BLAST 15.09691 No description for 2d5dA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • CoA carboxylase activity
    		•  9.83581323285097 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  9.81059565938621 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  9.76633430002009 bayes_pls_golite062009
  • ligase activity
    		•  7.71401892529536 bayes_pls_golite062009
  • biotin carboxylase activity
    		•  6.9547407447638 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  4.25267317906061 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  4.17451795830682 bayes_pls_golite062009
  • methylcrotonoyl-CoA carboxylase activity
    		•  2.98357921316004 bayes_pls_golite062009
  • catalytic activity
    		•  2.5009559386228 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.20282197109991 bayes_pls_golite062009
  • succinate-CoA ligase activity
    		•  2.14741613881765 bayes_pls_golite062009
  • CoA-ligase activity
    		•  1.74681936947183 bayes_pls_golite062009
  • phosphoribosylaminoimidazole carboxylase activity
    		•  1.57708889650281 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  1.54123288984373 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  1.25618100691869 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.11645327303429 bayes_pls_golite062009
  • phosphoribosylamine-glycine ligase activity
    		•  1.04915286326924 bayes_pls_golite062009
  • glutathione binding
    		•  1.01891534702164 bayes_pls_golite062009
  • propionyl-CoA carboxylase activity
    		•  0.643677287269589 bayes_pls_golite062009
  • glutathione synthase activity
    		•  0.197350998474496 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  0.07169743897532 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  0.034607288669523 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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