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Protein Overview: sex-1

General Information:
Name(s) found: sex-1 / CE03323 [WormBase]
Description(s) found:
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  • WBGene00004786 locus:sex-1 Steroid hormone receptor family member cnr14 status:Confirmed UniProt:P41830 protein_id:CAA90722.1 [WormBase]
  • pir||T22154 hypothetical protein F44A6.2 - Caenorhabditis elegans [NCBI NR]
  • gi|71990178|ref|NP_001024662.1| Signal Element on X family member (sex-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|3877091|emb|CAA90722.1| C. elegans protein F44A6.2, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_509713.2| nuclear Hormone Receptor, X-chromosome counting element, determines nematode sex, probably a transcriptional repressor, Signal Element on X SEX-1 (60.8 kD) (sex-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|1705961|sp|P41830.2|CNR14_CAEEL RecName: Full=Steroid hormone receptor family member cnr14; AltName: Full=Nuclear receptor subfamily 1 group G member 1 [NCBI NR]
  • gi|1203792|gb|AAA96982.1| steroid hormone receptor family member CNR14 [NCBI NR]
  • (P41830) Steroid hormone receptor family member cnr14 [Swiss-Prot]
  • Steroid hormone receptor family member cnr14 OS=Caenorhabditis elegans GN=cnr-14 PE=2 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE03323 WBGene00004786 locus:sex-1 nuclear hormone receptor status:Confirmed SW:P41830 protein_id:CAA90722.1 [wormpep150.fasta]
  • 03323 WBGene00004786 locus:sex-1 nuclear hormone receptor status:Confirmed SW:P41830 protein_id:CAA90722.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • nuclear Hormone Receptor, X-chromosome counting element, determines nematode sex, probably a transcriptional repressor, Signal Element on X SEX-1 (60.8 kD) (sex-1) [Caenorhabditis elegans]gi|3877091|emb|CAA90722.1| Hypothetical protein F44A6.2a [Caenorha [nrdb_11152004_Chlamydomonas]
  • locus:sex-1 nuclear hormone receptor status:Confirmed SW:P41830 protein_id:CAA90722.1 [wormpep115.fasta.reversed]
  • CE03323 locus:sex-1 nuclear hormone receptor status:Confirmed SW:P41830 protein_id:CAA90722.1 [wormpep80.hongbin]
  • CE03323 WBGene00004786 locus:sex-1 nuclear hormone receptor status:Confirmed UniProt:P41830 protein_id:CAA90722.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE03323 WBGene00004786 locus:sex-1 nuclear hormone receptor status:Confirmed UniProt:P41830 protein_id:CAA90722.1| [wormORF-contam.fasta]
  • Signal Element on X family member (sex-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • steroid hormone receptor family member CNR14 [nr-271106-contam.fasta]
  • Hypothetical protein F44A6.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Steroid hormone receptor family member cnr14 [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE03323 WBGene00004786 locus:sex-1 status:Confirmed UniProt:P41830 protein_id:CAA90722.1 Steroid hormone receptor family member cnr14 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    negative regulation of transcription [IDALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed articleLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    sex determination [IGILink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    ligand-dependent nuclear receptor activity [ISSLink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFETKPNYL LLTNPDTPLS VCTSPYYSPS GKTASIPSSE ASKPEGTNGQ WSHLPTGATY  60
   61 VTDEFSSEFQ IQNGSTAAQS GNANNYADPL SHRRYFNNVN GYNHHQFYDT ASQASVSSPA 120
  121 TSVTSSLSPP DSLSNGHTTQ RHHIGKAISF CKVCGDKASG YHYGVTSCEG CKGFFRRSIQ 180
  181 RKIDYRCLKQ QVCEIKRESR NRCQYCRFKK CLDSGMSKDS VRQMKFRNAM RDDKSPDSVF 240
  241 VPEISTLERQ EEVDAVYEAV LRAHTTFSFY TDIKIRSIVA RPFNVRINED SKMNRLNAWQ 300
  301 IYAHEIDVDI KEVVNFVKEI PKFNFINGND KAVLLRKNAF PLYLLRIVRG MSNRGLMLRD 360
  361 GRLIDFKSLQ LLYGSLADEM LAFANHIITI GCTDGDIALF IVLILCQPLT TEQQFSTNFK 420
  421 SQLQLLEMFD FYKKVLFQKM TCRIDGCDTY KQLMKCIHEL NRLNELHKQQ LNILRENLSF 480
  481 LNLPPLVVEM FQLSTLPLPV NHNNQENQYT PAPEHQSPQP QQPTPNQQQT PVHC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] MSA 2.322992 View MSA. No confident structure predictions are available.
    2 View Details [140..227] PSI-BLAST 20.522879 No description for 2hanB was found.
    3 View Details [228..534] PSI-BLAST 50.0 Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.91348392022358 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • hormone receptor binding
    		•  1.8288193687002 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  1.72196998170947 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.62841402245495 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62405765585032 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • androgen receptor binding
    		•  1.48596869620742 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.46067968492906 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  1.28090460550476 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.14370842685155 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.10242633521642 bayes_pls_golite062009
  • structural molecule activity
    		•  1.03433454627943 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.979635034577337 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • receptor activity
    		•  0.230063209127305 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    3
    Term Confidence Notes
  • vitamin D3 receptor activity
    		•  5.5563493713822 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  4.81441024181511 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  4.66615836207965 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.91470119037087 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.79647267365529 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription activator activity
    		•  3.20381581407476 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.01488410150634 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • receptor activity
    		•  2.62895787183554 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • vitamin D binding
    		•  2.05947211013242 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • signal transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • prostacyclin receptor activity
    		•  1.74944518684208 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.56146647486761 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.48246587604476 bayes_pls_golite062009
  • estrogen receptor activity
    		•  1.47290778095383 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.23834725221597 bayes_pls_golite062009
  • promoter binding
    		•  1.16363620574097 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • juvenile hormone binding
    		•  0.814202236506491 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.754240851368212 bayes_pls_golite062009
  • steroid binding
    		•  0.687964316511791 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • retinoid binding
    		•  0.234953048620166 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.190887599354128 bayes_pls_golite062009
  • lipid binding
    		•  0.164046651023989 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009
  • estrogen response element binding
    		•  4.73336420190096E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle