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Protein Overview: emb-8

General Information:
Name(s) found: emb-8 / CE02018 [WormBase]
Description(s) found:
Found 21 descriptions.
SHOW ALL
  • WBGene00001262 locus:emb-8 NADPH--cytochrome P450 reductase status:Confirmed UniProt:Q09590 protein_id:CCD72861.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 662 amino acids

    Gene Ontology:
    Cellular Component: thylakoid membrane [IEALink to PubMed article]
    Biological Process: oocyte construction [IMPLink to PubMed article]
    electron transport [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    nitric oxide biosynthetic process [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: calmodulin binding [IEALink to PubMed article]
    NADP or NADPH binding [IEALink to PubMed article]
    FMN binding [IEALink to PubMed article]
    nitric-oxide synthase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    iron ion binding [IEALink to PubMed article]
    FAD binding [IEALink to PubMed article]
    2 iron, 2 sulfur cluster binding [IEALink to PubMed article]
    ferredoxin-NADP+ reductase activity [IEALink to PubMed article]
    heme binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAWIVSGLD TSDLVVLTLL AGGAIIFLFM KVFNQQPSSS RYSPTVASVT TSAAASKSNQ  60
   61 SFIDRMKNEN RQVLIMYGSQ TGTAEEMSGR LAKDLTRYTK KAVVVDPEDI ECEDLNRLSE 120
  121 VEDALLVLCI ATYGEGDPTD NAVTLVEYLN AGDCDLSGVR FAVFGLGNKT YEHFNEIGIQ 180
  181 MDKQLEKLGA KRIFHLGLGD DDANLEEDFM IWREAFLPKV AEEFGWELNT EAETMRQYQL 240
  241 EPVEEGKALF KGEFGRLGAY ERPRPPFDVK NPYLATVAIN DELHTEHSDR SCRHIEFSVE 300
  301 GSRIRYEAGD HLAVFPTNDP VLVDRLINML QFDPDHAFRL VNVDEDASKR HPFPCPTTFR 360
  361 TALSHYVDIC APVKSHVLKA ISEYCTDDTE KEFLNKLSTA NEEGLKEYAR YIVKERRSIV 420
  421 DVLTDQKTCK PPIEYLLELL PRLQARYYSI ASSPRLNEEK IAICAVVTKY SIGDRDINGV 480
  481 CTRYLTTKDA GSKSPVFVRK STMRLPHRTT TQVIMIGPGT GFAPFRGFLQ DRQFHKNAGK 540
  541 EIGAMHLYYG CRHPDHDYIY KDELAKFQED EVLTHLVCAF SRAQEHKIYV QDRLWETRDR 600
  601 IWDAINVGAH VYICGDARNM ARDVQATLQK IFREIGGKSE TEAVAYFKDM EKTKRYQADV 660
  661 WS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..662] PSI-BLAST 147.0 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • sulfite reductase (NADPH) activity
    		•  8.084406223553 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  4.30314846685644 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  4.19887641848781 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  4.06091555929351 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  3.8525097290463 bayes_pls_golite062009
  • arginine binding
    		•  3.31453699236145 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
    		•  3.111558299994 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  3.09973680094998 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.02740987944465 bayes_pls_golite062009
  • tetrahydrobiopterin binding
    		•  3.017442325411 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  3.01705400717654 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.84592668144284 bayes_pls_golite062009
  • FAD binding
    		•  2.07600122867642 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.07119387257991 bayes_pls_golite062009
  • coenzyme binding
    		•  1.94345417147733 bayes_pls_golite062009
  • binding
    		•  1.76189957257133 bayes_pls_golite062009
  • nitric-oxide synthase activity
    		•  1.73361245661515 bayes_pls_golite062009
  • cytochrome-b5 reductase activity
    		•  1.5685421124725 bayes_pls_golite062009
  • ferredoxin-NADP+ reductase activity
    		•  1.46342400843015 bayes_pls_golite062009
  • ferredoxin reductase activity
    		•  1.46342400843015 bayes_pls_golite062009
  • oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
    		•  1.46342400843015 bayes_pls_golite062009
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  1.30413377266725 bayes_pls_golite062009
  • monooxygenase activity
    		•  1.24895114339483 bayes_pls_golite062009
  • NADP or NADPH binding
    		•  1.18833847639357 bayes_pls_golite062009
  • demethylase activity
    		•  1.1768217851058 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  1.11231803143399 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  0.878188072733981 bayes_pls_golite062009
  • transferase activity
    		•  0.708491789248912 bayes_pls_golite062009
  • FMN binding
    		•  0.649158247260553 bayes_pls_golite062009
  • NAD(P)H oxidase activity
    		•  0.46219666758416 bayes_pls_golite062009
  • riboflavin synthase activity
    		•  0.380537461428523 bayes_pls_golite062009
  • protein binding
    		•  0.244726474314668 bayes_pls_golite062009
  • cofactor binding
    		•  0.205324283520452 bayes_pls_golite062009
  • transcription factor binding
    		•  0.065157440608373 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0373671593900911 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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