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Protein Overview: tbx-2

General Information:
Name(s) found: tbx-2 / CE01245 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00006543 locus:tbx-2 T-box protein 2 status:Partially_confirmed UniProt:Q19691 protein_id:CCD69847.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article][ISSLink to PubMed article]
    transcription factor complex [ISSLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: muscle organ development [IMPLink to PubMed articleLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    locomotion [IMPLink to PubMed article]
    regulation of protein localization [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    muscle cell fate specification [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    olfactory behavior [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    protein binding [IPILink to PubMed article]
    RNA polymerase II transcription factor activity, enhancer binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFNPFALGR PDLLLPFMGA GVGGPGAGGP PPNLFFSMLQ AGFPPGPVGS PPEDDGVTDD  60
   61 PKVELDEREL WQQFSQCGTE MVITKSGRRI FPAYRVKISG LDKKSQYFVM MDLVPADEHR 120
  121 YKFNNSRWMI AGKADPEMPK TLYIHPDSPS TGEHWMSKGA NFHKLKLTNN ISDKHGYTIL 180
  181 NSMHKYQPRL HVVRCADRHN LMYSTFRTFV FRETEFIAVT AYQNEKVTEL KIENNPFAKG 240
  241 FRDAGAGKRE KKRQLHRMNG DATQSPPGKT ASLPTHSPHP SESNSEDDEP TLKKCKPEPS 300
  301 QTPTTSSLST STTPTLSAHH PLRSPQFCIP PPIDMMYQNM PMDLLAHWQM ATLFPQFSMA 360
  361 LNSPAAAASL LSKHLAKASS ECKVEATSED SEEAEKPEVK KEQKSVTPPK KGGFDVLDLL 420
  421 SKP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..252] PSI-BLAST 88.522879 T-box protein 3, tbx3
    2 View Details [253..423] MSA 9.255996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.29102864831653 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.92025295308511 bayes_pls_golite062009
  • DNA binding
    		•  1.86143461884692 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.68075928646599 bayes_pls_golite062009
  • transcription factor activity
    		•  1.33446362838411 bayes_pls_golite062009
  • protein binding
    		•  0.74749676675118 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.47331695689559 bayes_pls_golite062009
  • transcription activator activity
    		•  0.33290695293257 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.0812057721813604 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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