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Protein Overview: mis16

General Information:
Name(s) found: mis16 / SPCC1672.10 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • kinetochore protein Mis16 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    nuclear chromatin [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Mis6-Sim4 complex [TASLink to PubMed article]
    Biological Process: chromosome segregation [IMPLink to PubMed article]
    kinetochore assembly [TASLink to PubMed article]
    chromatin remodeling at centromere [IMPLink to PubMed article]
    regulation of histone deacetylation at centromere [IMPLink to PubMed article]
    histone deacetylation [IMPLink to PubMed article]
    CenH3-containing nucleosome assembly at centromere [TASLink to PubMed article]
    cellular protein localization [IGILink to PubMed article]
    cell cycle [RCALink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEEVVQDAP LENNELNAEI DLQKTIQEEY KLWKQNVPFL YDLVITHALE WPSLTIQWLP  60
   61 DKKTIPGTDY SIQRLILGTH TSGNDQNYLQ IASVQLPNFD EDTTEFTPST IRRAQATGSY 120
  121 TIEISQKIPH DGDVNRARYM PQKPEIIATM GEGGNAYIFD TTCHDALTTG EALPQAVLKG 180
  181 HTAEGFGLCW NPNLPGNLAT GAEDQVICLW DVQTQSFTSS ETKVISPIAK YHRHTDIVND 240
  241 VQFHPQHEAL LASVSDDCTL QIHDTRLNPE EEAPKVIQAH SKAINAVAIN PFNDYLLATA 300
  301 SADKTVALWD LRNPYQRLHT LEGHEDEVYG LEWSPHDEPI LASSSTDRRV CIWDLEKIGE 360
  361 EQTPEDAEDG SPELLFMHGG HTNRISEFSW CPNERWVVGS LADDNILQIW SPSRVIWGRD 420
  421 HVQVSPRDLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..430] PSI-BLAST 27.0 Actin interacting protein 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone methyltransferase activity (H3-K4 specific)
    		•  4.71992275913384 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.85374902981345 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35098520158193 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31615347567536 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.14917998298348 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.79445416141967 bayes_pls_golite062009
  • peroxisome targeting sequence binding
    		•  2.43196533618619 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20122168933317 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.18628561734369 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.85632145559025 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • actin binding
    		•  1.40054662654509 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.35170368882651 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • tubulin binding
    		•  1.10875870970504 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • microtubule binding
    		•  1.03769395387791 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  1.01962930136588 bayes_pls_golite062009
  • dynein binding
    		•  0.99104010024574 bayes_pls_golite062009
    		• 0.88172763425403 bayes_pls_golite062009
  • transporter activity
    		•  0.692270256454453 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.428715007921149 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • snoRNA binding
    		•  0.347797037104681 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.161639372576406 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.121183207943714 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle