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Protein Overview: iki3

General Information:
Name(s) found: iki3 / SPBC36.07 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • RNA polymerase II elongator subunit Iki3 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1253 amino acids

    Gene Ontology:
    Cellular Component: Elongator holoenzyme complex [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: tRNA modification [ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNLVTHLHH VFPNVNGSIK ALAFNSISDK IYVVCGLDNE NPGIEIYEIS ENDDVSKLVE  60
   61 FDSPSFVSDN GDIDEIQSMQ FLGEPMAICL SLKGGDIVMV KVDPSPEEAP WEIIGNVENG 120
  121 IVASCWSTDE QVFCIITGGD TILFMTKNFD IISETSLSDA DLNEFNKHIS VGWGRSETQF 180
  181 RGKRVRAKLR DPTLPEKIDE GKLSDVDDGK TYICWRGDSQ YVSINRLEKG PRRAIRVYSR 240
  241 EGLLDSISEP QDGQQSLLSW KPSGSVLATI KSDSSDNSSK VIFFERNGLR HGEFSLRRRE 300
  301 DEKYTGLAWN VSSSILAVST ENSVMLWTTG NYHWYLKKEI NIPQNALISW HPEHANTLYI 360
  361 TGKNHIEKVV FDLKYVTEFS TSPNDFGLIP VIDGSSLLVT PLSLCNIPPP MCRYKLSLDY 420
  421 NVQMTSINAT SDMLFAADDR RLTAFTFNSQ EDIAKFGEFD ISTYAEGLNF KSLLGLSGNQ 480
  481 VLLLADGTNN CSKFFVFQCD EDNESLKLLA SESFESCILN ASYCSEMLFF QTSSGKLISY 540
  541 NLNVKSIESI SLSFPKPCSD FVVVPVHETF VPIGLTSYGR LYAEQRLLST GVLSFFCTER 600
  601 FVLFTTTKNL LKFVHLVSTV DDLQVVEDDA VDRHDERCRV VERGSKIVAS MPSKMAVVLQ 660
  661 MPRGNLETIY PRIMVLDGVR TYIKALKYGD AFKVCRTHRL DLNILFDYDP DLFLKNIPVF 720
  721 VDGLYRVDYL DLFLTSLKPE NVTTGMYSDT SKSQSQQSVT TIDNKVNLLC KIIREHLTSK 780
  781 YGDTHFQAII TSYLCESPPK IEAALGMISG LIKAQSETVD LAIEHMCFLV DVNMLFDHAL 840
  841 GLYDLKLALL IAQQSQKDPR EYVPFLHEFQ KQESLRRKFN IDCYLKRYER ALGHLKEMEN 900
  901 AFDEFKNFTI QHKLYPRALE LYKYDKEAQK EVLIIFAQYL RENGKSNEAA IAYESVGKIS 960
  961 EAIEAYKSAG MWRECLSILQ QTTNSEDLIR ETAEDLASLC IEKREHCDAG SINLLYLSNP1020
 1021 REAVIQMCKG SQYSEAIRIA RATGDSSIYK DLLISVLGES FGEASELVAD FRNQIKSQTE1080
 1081 RILVLREKKK EDPISWMEGT MEDQTPDDIS LASTSLSTNR SLYTQYTKSS NSSKMTRNTS1140
 1141 KNNRRLERKR ARGKKGTVFE EEYLVNSLRR LIARVEEIRP EVHRLLEALV RCNMTTQASE1200
 1201 LQRNFANVIG TIGEKVIPIL SVPVSTFETA LGEQPQAPVV PNVKPFEKLS ILI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..621] PSI-BLAST 41.0 Actin interacting protein 1
    2 View Details [622..755] PSI-BLAST 4.0 No description for 2gbcA was found.
    3 View Details [756..857] deduced N/A No confident structure predictions are available.
    4 View Details [858..1028] PSI-BLAST 6.154902 Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
    5 View Details [1029..1098] deduced N/A No confident structure predictions are available.
    6 View Details [1099..1253] MSA 1.047969 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • snoRNA binding
    		•  3.21038659166441 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.99343906593123 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
    		• 2.40807791198019 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.5281054405163 bayes_pls_golite062009
  • kinase activity
    		•  1.5053563627859 bayes_pls_golite062009
  • RNA binding
    		•  1.50295916950465 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.33036729957356 bayes_pls_golite062009
  • protein kinase activity
    		•  1.3214585007945 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • ligase activity
    		•  0.93058496790047 bayes_pls_golite062009
  • transferase activity
    		•  0.913674310517261 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.722742354759599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.658573452658359 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.618638900707402 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.28606552120995 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  0.262596110845942 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.182612389752591 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • actin binding
    		•  0.00606924241186668 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle