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Protein Overview: apl3

General Information:
Name(s) found: apl3 / SPBC691.03c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • AP-2 adaptor complex subunit Alp3 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 878 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cell cortex [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    AP-2 adaptor complex [ISSLink to PubMed article]
    Biological Process: vesicle-mediated transport [ISSLink to PubMed article]
    intracellular protein transport [ICLink to PubMed article]
    Molecular Function: protein transporter activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVASNNMKGL RAFISDLRSL EHDDEEKRVN VELAKIRAKF QSSTLSAYDR KKYVSKLLYI  60
   61 YMLGYPITFG HMEAAKLLSG TKYSEKLIGY LAVALLLNEN HELMKLVINS IKKDLLSHDS 120
  121 LQNSLALHTI ANIGGRELCE TVYYDIYKLL MSASNENIVR QKSALALLHI YRKFPDLINP 180
  181 EWFEPIVMIL GDDDLNVSLA VSNFVNLIVI REPKYQKFAY GKAVGKLKNI VFEHGYSSDY 240
  241 LYYSVPCPWL QVNLCRILLA CERPSDNPTR ATLIRVLDRI LSLPNDNSNV QQVNAVNAIL 300
  301 FEAIKLAFLV DESHSLYEKC MDRLADMIAD KESNIRYLAF ETTAYLISCG HSITSLKHYK 360
  361 ELILSSLRYK DVSLRKKSLE LLYMMCDEEN AKLIVADLLQ YLPHLDSVTQ EDLISKVAII 420
  421 SETFATDYEW YVDVTIQLLR IAGKSADDGV WHQLVHVIVN NEEIQEYATK RLFSLLQSET 480
  481 IHECLVKAGG YVLGEFGHLI TDYPDSQPVH QFSTIYRKLN VSSPSTRVLL LTTLIKLANL 540
  541 QPELNDRIAK VFQEYSTIIN PEVQQRACEY LQLLKMPRDF LQLVCDEVPP FLDGNRDGVH 600
  601 PKSRPSSKVN LVDTYPQTIP NVSKPSTPID VPEYDISACL PGFYRLCWKD KGILYQDSQI 660
  661 QIGVRSEYHN SEGAIYLYYE NRQSNTLKSL SSTLIRTFST FHLATTFQDT NLPSGVQLQQ 720
  721 KYVMSGVNEI FEPPIIHVSY VTGVIRSIDL QLPVLLSKFM KPTIFDSYDF FNHWGQMGVE 780
  781 REAQLTFGLN SKDRKLDAKR LTKIVSGFHW GICQNVDSIA LNIVGAGIIR FGTQNVGCLL 840
  841 RIEPNYEQNL IRLSIRSTNT SIANTLAKEM QEILRNSF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..507] PSI-BLAST 90.522879 Adaptin alpha C subunit N-terminal fragment
    2 View Details [508..594] PSI-BLAST 17.0 beta-Catenin
    3 View Details [595..878] PSI-BLAST 73.522879 Alpa-adaptin AP2 ear domain, N-terminal subdomain; Alpa-adaptin AP2, C-terminal subdomain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  4.70716704570713 bayes_pls_golite062009
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • binding
    		•  2.86831493830281 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.97003189625955 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.4515576307774 bayes_pls_golite062009
  • actin binding
    		•  1.4328432044371 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.877307852212156 bayes_pls_golite062009
  • signal transducer activity
    		•  0.877307852212156 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.877265261129885 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.753137855305501 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.221086931523202 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • DNA binding
    		•  0.164787712168699 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle