YRC Public Data Repository - Protein Structure Prediction

Protein:	apl3
Organism:	Schizosaccharomyces pombe
Length:	878 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for apl3.

Description	E-value	Query Range	Subject Range
gi\|162138932, gi... - gi\|51859448\|gb\|AAH81786.1\| Adaptor-related protein complex 2, alpha 2 subunit [Rattus norvegicus], g...	639.0	[0..3]	[874..6]
gi\|50510693 - gi\|50510693\|dbj\|BAD32332.1\| mKIAA0899 protein [Mus musculus]	636.0	[0..3]	[874..35]
gi\|109125572 - gi\|109125572\|ref\|XP_001115439.1\| PREDICTED: similar to adaptor-related protein complex 2, alpha 1 su...	630.0	[0..3]	[874..6]
AP2A2_BOVIN - AP-2 complex subunit alpha-2 OS=Bos taurus GN=AP2A2 PE=1 SV=1	629.0	[0..3]	[874..6]
gi\|62898848 - gi\|62898848\|dbj\|BAD97278.1\| adaptor-related protein complex 2, alpha 2 subunit variant [Homo sapiens...	628.0	[0..3]	[874..6]

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Predicted Domain #1

Region A:
Residues: [1-507]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVASNNMKGL RAFISDLRSL EHDDEEKRVN VELAKIRAKF QSSTLSAYDR KKYVSKLLYI  60
   61 YMLGYPITFG HMEAAKLLSG TKYSEKLIGY LAVALLLNEN HELMKLVINS IKKDLLSHDS 120
  121 LQNSLALHTI ANIGGRELCE TVYYDIYKLL MSASNENIVR QKSALALLHI YRKFPDLINP 180
  181 EWFEPIVMIL GDDDLNVSLA VSNFVNLIVI REPKYQKFAY GKAVGKLKNI VFEHGYSSDY 240
  241 LYYSVPCPWL QVNLCRILLA CERPSDNPTR ATLIRVLDRI LSLPNDNSNV QQVNAVNAIL 300
  301 FEAIKLAFLV DESHSLYEKC MDRLADMIAD KESNIRYLAF ETTAYLISCG HSITSLKHYK 360
  361 ELILSSLRYK DVSLRKKSLE LLYMMCDEEN AKLIVADLLQ YLPHLDSVTQ EDLISKVAII 420
  421 SETFATDYEW YVDVTIQLLR IAGKSADDGV WHQLVHVIVN NEEIQEYATK RLFSLLQSET 480
  481 IHECLVKAGG YVLGEFGHLI TDYPDSQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.522879
Match:	1gw5A
Description:	Adaptin alpha C subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
clathrin binding	4.70716704570713	bayes_pls_golite062009
protein transporter activity	4.58709163830613	bayes_pls_golite062009
binding	2.86831493830281	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
cytoskeletal protein binding	1.97003189625955	bayes_pls_golite062009
protein binding	1.63705839411934	bayes_pls_golite062009
protein transmembrane transporter activity	1.4515576307774	bayes_pls_golite062009
actin binding	1.4328432044371	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
molecular transducer activity	0.877307852212156	bayes_pls_golite062009
signal transducer activity	0.877307852212156	bayes_pls_golite062009
nucleic acid binding	0.877265261129885	bayes_pls_golite062009
nuclear localization sequence binding	0.753137855305501	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
transcription regulator activity	0.221086931523202	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
DNA binding	0.164787712168699	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [508-594]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVHQFSTIYR KLNVSSPSTR VLLLTTLIKL ANLQPELNDR IAKVFQEYST IINPEVQQRA  60
   61 CEYLQLLKMP RDFLQLVCDE VPPFLDG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.0
Match:	1g3jA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [595-878]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRDGVHPKSR PSSKVNLVDT YPQTIPNVSK PSTPIDVPEY DISACLPGFY RLCWKDKGIL  60
   61 YQDSQIQIGV RSEYHNSEGA IYLYYENRQS NTLKSLSSTL IRTFSTFHLA TTFQDTNLPS 120
  121 GVQLQQKYVM SGVNEIFEPP IIHVSYVTGV IRSIDLQLPV LLSKFMKPTI FDSYDFFNHW 180
  181 GQMGVEREAQ LTFGLNSKDR KLDAKRLTKI VSGFHWGICQ NVDSIALNIV GAGIIRFGTQ 240
  241 NVGCLLRIEP NYEQNLIRLS IRSTNTSIAN TLAKEMQEIL RNSF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.522879
Match:	1ky6A
Description:	Alpa-adaptin AP2 ear domain, N-terminal subdomain; Alpa-adaptin AP2, C-terminal subdomain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: