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Protein Overview: set1

General Information:
Name(s) found: set1 / SPCC306.04c [Sanger Pombe]
Description(s) found:
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  • pir||T41282 probable transcription silencing protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74698592|sp|Q9Y7R4.1|SET1_SCHPO RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-4 specific; AltName: Full=Set1 complex component set1; Short=Set1C component set1; AltName: Full=COMPASS component set1; AltName: Full=SET domain-containing pro [NCBI NR]
  • gi|4704279|emb|CAB41652.1| histone lysine methyltransferase Set1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075312|ref|NP_587812.1| histone lysine methyltransferase Set1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • histone lysine methyltransferase Set1 [Sanger Pombe]
  • Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Schizosaccharomyces pombe GN=set1 PE=1 SV=1 [Swiss-Prot]
  • SET DOMAIN PROTEIN; PUTATIVE CHROMATIN MEDIATED TRANSCRIPTIONAL SILENCING; SIMILAR TO S. CEREVISIAE SET1: Q9Y7R4; [pompepVF.fasta]
  • SET DOMAIN PROTEIN; TRANSCRIPTIONAL SILENCING: Q9Y7R4; [pompepV13]
  • Set domain protein, transcriptional silencing [pompep4896]
  • |set1||SET1 complex (TAP) (PMID 12488447) [pompepnew.fasta]
  • Set1 protein (Spcc306.04c protein) [4896.FASTAC]
  • |set1||SET1 complex (TAP) (PMID 12488447)|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • set domain protein; transcriptional silencing [Schizosaccharomyces pombe]gi|4704279|emb|CAB41652.1| SPCC306.04c [Schizosaccharomyces pombe]gi|7493085|pir||T41282 probable transcription silencing protein - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |set1||histone lysine methyltransferase|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • (Q9Y7R4) Set domain protein, transcriptional silencing [pompep4896_normal_reversed]
  • |set1||histone lysine methyltransferase Set1|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Histone-lysine N-methyltransferase, H3 lysine-4 specific (Set1 complex component set1) (Set1C component set1) (COMPASS component set1) (SET domain-containing protein 1) (Spset1) [nr-271106-contam.fasta]
  • hypothetical protein SPCC306.04c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPCC306.04c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • |set1|kmt2|histone lysine methyltransferase Set1|Schizosaccharomyces pombe|chr 3|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=set1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 920 amino acids

    Gene Ontology:
    Cellular Component: Set1C/COMPASS complex [IDALink to PubMed article]
    nuclear chromatin [NAS]
    cytoplasm [IDALink to PubMed article]
    Biological Process: DNA damage checkpoint [IGILink to PubMed article]
    chromatin remodeling [ISSLink to PubMed article]
    histone methylation [ICLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    [NOT]chromatin silencing [IMPLink to PubMed article]
    Molecular Function: histone methyltransferase activity (H3-K4 specific) [TASLink to PubMed article]
    RNA binding [ISSLink to PubMed article]
    histone-lysine N-methyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFNTSTRSK SQPVQRNNYK VLYDPELGIK ENLGRKIIYR FNGVSKPPLV VRDPRLKNPI  60
   61 YARGIPKSGR PFLKSLQTIN YDYNENSLGP EPPTQVFVSN ISPLVTSEQL RYHFKSFGEV 120
  121 FDLDLKLNPY TGTSLGLCCI SFDKRSSISV AAHSAKIAVQ QANGLRFSGK PLSVVLDRDG 180
  181 SLCEEAFKKA LNAVEKQFQE ETLQKQRFER EDESSRQKLS AAMNEDIPPW RQPSKNSQTL 240
  241 SNGDLQHSKV QNVDQKSGFL TSSETDVPKN INDYIYLLID DRFVPPDRVY YTDIKHHFRK 300
  301 FLYEKIYMNK DGFYITFNNY REASNCYRAL DRTYVQNCRI KLKFHDIPSR TKEDGKKSAV 360
  361 RRVVLPPEEA YAEATSVVLR DLEAALLRDV KSKIIGPAIF KYLHSMPKPS VKEELQENLL 420
  421 VSSTSVPDVP LKIESTVGKL PSLPKFKKRV DSSKMNLSAG SKTKSKLQRR RRRRHEARPL 480
  481 HYQLNQMYNS SASEAESDQE LLLSSGDERV ERGKIGSIKS VKSDEATPVF SDTSDENDKF 540
  541 HRFRTKSKIS KKKYEKMEVD YTSSSETESD ASILSPSAAI PKSGSAIKDE LISPKKEIDE 600
  601 VLALAPKWRI NEFDETGSVY YGALPYNYPE DDVLLDLDGL QYLVKNDEDY SYLQEALKDE 660
  661 PLMDINDPNF WAYERKSCKF KNGDVKYGDT AILPEPKGYF RSNTSGSAKS EGYYIIPTTE 720
  721 KSLYLPLRNR STIDTISHST SRITSRMNRV NNRRLAAGVE KSQLPAEADL LRFNALKARK 780
  781 KQLHFGPSRI HTLGLFAMEN IDKNDMVIEY IGEIIRQRVA DNREKNYVRE GIGDSYLFRI 840
  841 DEDVIVDATK KGNIARFINH SCAPNCIARI IRVEGKRKIV IYADRDIMHG EELTYDYKFP 900
  901 EEADKIPCLC GAPTCRGYLN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..285] PSI-BLAST 42.39794 HNRNP A1 (RBD1,2) FROM HOMO SAPIENS
    2 View Details [286..363] PSI-BLAST 5.221849 No description for 2go9A was found.
    3 View Details [364..583] deduced N/A No confident structure predictions are available.
    4 View Details [584..920] PSI-BLAST 54.39794 No description for 2r3aA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • telomeric DNA binding
    		•  4.03831655839461 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.49140899351099 bayes_pls_golite062009
  • RNA binding
    		•  2.47430823231895 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  1.45281129851941 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.44189759422835 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.35024639492346 bayes_pls_golite062009
  • mRNA binding
    		•  1.30169099150772 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • DNA binding
    		•  0.563753238006617 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.400831329848221 bayes_pls_golite062009
  • structural molecule activity
    		•  0.347575413104581 bayes_pls_golite062009
    		• 0.269380373063071 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.220812525173636 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle