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View Structure Prediction Details

Protein: set1
Organism: Schizosaccharomyces pombe
Length: 920 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for set1.

Description E-value Query
Range
Subject
Range
SET1_CANAL - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Candida albicans (strain SC5314 / ATCC M...
SET1_CANAL - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Candida albicans GN=SET1 PE=3 SV=1
304.0 [0..5] [920..134]
SET1_EMENI - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Emericella nidulans GN=set1 PE=3 SV=1
SET1_EMENI - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Emericella nidulans (strain FGSC A4 / AT...
291.0 [0..16] [920..178]
gi|49656923, gi|... - gi|50425321|ref|XP_461254.1| hypothetical protein DEHA0F22176g [Debaryomyces hansenii CBS767], gi|49...
SET1_DEBHA - Histone-lysine N-methyltransferase, H3 lysine-4 specific - Debaryomyces hansenii (Yeast) (Torulaspor...
285.0 [0..16] [920..163]
SET1_YARLI - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Yarrowia lipolytica GN=SET1 PE=3 SV=1
SET1_YARLI - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Yarrowia lipolytica (strain CLIB 122 / E...
280.0 [0..7] [920..318]
SET1_ASHGO - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Ashbya gossypii GN=SET1 PE=3 SV=1
SET1_ASHGO - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Ashbya gossypii (strain ATCC 10895 / CBS...
278.0 [0..32] [920..108]
gi|114560105, gi... - gi|114560107|ref|XP_001160638.1| PREDICTED: ash1 (absent, small, or homeotic)-like isoform 1 [Pan tr...
278.0 [0..360] [919..1749]
gi|225000936 - gi|225000936|gb|AAI72595.1| Ash1 (absent, small, or homeotic)-like (Drosophila) [synthetic construct...
gi|122889180, gi... - gi|123289370|emb|CAI13211.2| ash1 (absent, small, or homeotic)-like (Drosophila) [Homo sapiens], gi|...
278.0 [0..360] [919..1749]
gi|109489033 - gi|109489033|ref|XP_220986.4| PREDICTED: similar to Enhancer of zeste homolog 1 (ENX-2) [Rattus norv...
277.0 [0..340] [903..177]

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Predicted Domain #1
Region A:
Residues: [1-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFNTSTRSK SQPVQRNNYK VLYDPELGIK ENLGRKIIYR FNGVSKPPLV VRDPRLKNPI  60
   61 YARGIPKSGR PFLKSLQTIN YDYNENSLGP EPPTQVFVSN ISPLVTSEQL RYHFKSFGEV 120
  121 FDLDLKLNPY TGTSLGLCCI SFDKRSSISV AAHSAKIAVQ QANGLRFSGK PLSVVLDRDG 180
  181 SLCEEAFKKA LNAVEKQFQE ETLQKQRFER EDESSRQKLS AAMNEDIPPW RQPSKNSQTL 240
  241 SNGDLQHSKV QNVDQKSGFL TSSETDVPKN INDYIYLLID DRFVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.39794
Match: 1ha1A
Description: HNRNP A1 (RBD1,2) FROM HOMO SAPIENS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 4.03831655839461 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
nucleic acid binding 3.49140899351099 bayes_pls_golite062009
RNA binding 2.47430823231895 bayes_pls_golite062009
single-stranded telomeric DNA binding 1.45281129851941 bayes_pls_golite062009
structure-specific DNA binding 1.44189759422835 bayes_pls_golite062009
single-stranded DNA binding 1.35024639492346 bayes_pls_golite062009
mRNA binding 1.30169099150772 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
DNA binding 0.563753238006617 bayes_pls_golite062009
transcription regulator activity 0.400831329848221 bayes_pls_golite062009
structural molecule activity 0.347575413104581 bayes_pls_golite062009
0.269380373063071 bayes_pls_golite062009
cytoskeletal protein binding 0.220812525173636 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [286-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDRVYYTDIK HHFRKFLYEK IYMNKDGFYI TFNNYREASN CYRALDRTYV QNCRIKLKFH  60
   61 DIPSRTKEDG KKSAVRRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.221849
Match: 2go9A
Description: No description for 2go9A was found.

Predicted Domain #3
Region A:
Residues: [364-583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLPPEEAYAE ATSVVLRDLE AALLRDVKSK IIGPAIFKYL HSMPKPSVKE ELQENLLVSS  60
   61 TSVPDVPLKI ESTVGKLPSL PKFKKRVDSS KMNLSAGSKT KSKLQRRRRR RHEARPLHYQ 120
  121 LNQMYNSSAS EAESDQELLL SSGDERVERG KIGSIKSVKS DEATPVFSDT SDENDKFHRF 180
  181 RTKSKISKKK YEKMEVDYTS SSETESDASI LSPSAAIPKS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [584-920]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSAIKDELIS PKKEIDEVLA LAPKWRINEF DETGSVYYGA LPYNYPEDDV LLDLDGLQYL  60
   61 VKNDEDYSYL QEALKDEPLM DINDPNFWAY ERKSCKFKNG DVKYGDTAIL PEPKGYFRSN 120
  121 TSGSAKSEGY YIIPTTEKSL YLPLRNRSTI DTISHSTSRI TSRMNRVNNR RLAAGVEKSQ 180
  181 LPAEADLLRF NALKARKKQL HFGPSRIHTL GLFAMENIDK NDMVIEYIGE IIRQRVADNR 240
  241 EKNYVREGIG DSYLFRIDED VIVDATKKGN IARFINHSCA PNCIARIIRV EGKRKIVIYA 300
  301 DRDIMHGEEL TYDYKFPEEA DKIPCLCGAP TCRGYLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.39794
Match: 2r3aA
Description: No description for 2r3aA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle