Protein Overview: SPBC839.16

General Information:
Name(s) found:	SPBC839.16 [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	pir\|\|T40723 c-1-tetrahydrofolate synthase - fission yeast (Schizosaccharomyces pombe) [NCBI NR] gi\|74622501\|sp\|Q8WZJ7.1\|C1TC_SCHPO RecName: Full=C-1-tetrahydrofolate synthase, cytoplasmic; Short=C1-THF synthase; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; Includes: [NCBI NR] gi\|5441479\|emb\|CAB46709.1\| C1-5,6,7,8-tetrahydrofolate (THF) synthase [Schizosaccharomyces pombe] [NCBI NR] gi\|19112048\|ref\|NP_595256.1\| C-1-tetrahydrofolate synthase [Schizosaccharomyces pombe] [NCBI NR] C-1-tetrahydrofolate synthase [Sanger Pombe] C-1-tetrahydrofolate synthase, cytoplasmic OS=Schizosaccharomyces pombe GN=SPBC839.16 PE=2 SV=1 [Swiss-Prot] C-1-TETRAHYDROFOLATE SYNTHASE: CAB46709; [pompepVF.fasta] C-1-TETRAHYDROFOLATE SYNTHASE: ;N0ACC; [pompepV13] \|\|\|c-1-tetrahydrofolate synthase [pompepnew.fasta] SPBC839.16 protein [4896.FASTAC] \|\|\|C-1-tetrahydrofolate synthase (predicted)\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] \|\|\|C-1-tetrahydrofolate synthase\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pompep2242005.fasta] c-1-tetrahydrofolate synthase [Schizosaccharomyces pombe]gi\|5441479\|emb\|CAB46709.1\| SPBC839.16 [Schizosaccharomyces pombe]gi\|7490164\|pir\|\|T40723 c-1-tetrahydrofolate synthase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas] (Q8WZJ7) C-1-tetrahydrofolate synthase [pompep4896_normal_reversed] \|\|\|C1-5,6,7,8-tetrahydrofolate \|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] SPBC839.16 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] c-1-tetrahydrofolate synthase [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] C-1-tetrahydrofolate synthase, cytoplasmic OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC839.16 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	937 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA]
Biological Process:	folic acid biosynthetic process [IDA] 10-formyltetrahydrofolate biosynthetic process [IDA] purine base biosynthetic process [IDA] one-carbon metabolic process [IDA]
Molecular Function:	ATP binding [IEA] formate-tetrahydrofolate ligase activity [IDA] methenyltetrahydrofolate cyclohydrolase activity [IDA] methylenetetrahydrofolate dehydrogenase (NADP+) activity [IDA] single-stranded DNA binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLLEGTSL ARKVREELRE QISSIKSVDP YFNVSLKIIQ VGGREDSNVY VRMKTRAANE  60
   61 AGISCEHVNF PEDITEYDLL LAIKGFNEDP TVHGIIVQLP LPAHINEQII TEAVAPEKDV 120
  121 DGFCETNLGK LTKREGQPLF TACTPKGIMC ILKHYGINVQ GKHAVVIGRS NIVGRPMSIL 180
  181 LEKANATVTL CHSKTESIAD IVRTADIVVA AIGIPHFVKA DWLKKGVVAI DVGINSIPDA 240
  241 TKKSGYRLTG DIDFENAKEV ASAITPVPGS VGPMTVAMLL QNVVESAVRF RKMSRKRKPT 300
  301 LLPLKLQTPV PSDIEIARSQ TPKNIGDLAS EIGIAKSELE FYGSHKAKVN LEILQRLAHR 360
  361 RDGHYVVVTG ITPTPFGEGK STLTAGLVQA LSNLDKLAIA CVRQPSQGPT FGIKGGAAGG 420
  421 GYSQFIPMEE FNLHLTGDIH AITAATNLLA AAIDTRMFHE NTQSDAALYK RLTLVKGNKR 480
  481 EFAPVMFRRL KKLGIDKTNP EELTEEEQRK FARLDIEPST ISWNRTLDVN DRFLRKITIG 540
  541 ENPTEKGFTR QTGFDLSVAS ECMSVLALAT DLKDMRERLG RMVVASNKSG EPVTADDLGV 600
  601 GGALTVLLKD AIKPTLMQTL EGTPALVHAG PFANISIGAS SILADRIALK LAGTEVDEDA 660
  661 KKEAGYVVTE AGFASDIGME KFFNIKCRTS GLKPDAIVIV ATVQALKLHG GGPPVGPGKP 720
  721 IPEVYKREDV DLVRKGCANL AKHISNARKY GLPVVVAINK FSSDSPNEIS AIREEALAAG 780
  781 ATDAVDSNHW AEGGKGALGV ARALINACEN VDSEFRLLYD VHEPIEKKIE IIAKEMYGAD 840
  841 GIELSPLAKE RLETFTKQGY NNLPICIAKT QYSLSHDPDL KGAPTNFTVP IRDMRLSAGA 900
  901 GFIYPLAAAI STIPGLPTKP AYYNIDIAEN GDIVGLS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
translation initiation factor activity	2.41232228963167	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.55478124277326	bayes_pls_golite062009
histone acetyltransferase activity	1.55478124277326	bayes_pls_golite062009
hydrolase activity	1.29060292615008	bayes_pls_golite062009
purine ribonucleotide binding	1.1110976601505	bayes_pls_golite062009
ribonucleotide binding	1.11103644113672	bayes_pls_golite062009
purine nucleotide binding	1.1086792521709	bayes_pls_golite062009
nucleotide binding	1.1060655022247	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.854899277460172	bayes_pls_golite062009
RNA helicase activity	0.81256037545135	bayes_pls_golite062009
ATP binding	0.80197288940364	bayes_pls_golite062009
adenyl ribonucleotide binding	0.770085840885632	bayes_pls_golite062009
adenyl nucleotide binding	0.751575230566049	bayes_pls_golite062009
RNA-dependent ATPase activity	0.74918137191219	bayes_pls_golite062009
structural constituent of ribosome	0.738234102557832	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.694120974355463	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.69117331267457	bayes_pls_golite062009
N-acyltransferase activity	0.581315571752634	bayes_pls_golite062009
N-acetyltransferase activity	0.487240078246257	bayes_pls_golite062009
kinase activity	0.431162005044036	bayes_pls_golite062009
ligase activity	0.417681194526243	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.347619818489809	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.250756824614616	bayes_pls_golite062009
acetyltransferase activity	0.190660928077915	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.12351419478929	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
structural molecule activity	0.0558641287316701	bayes_pls_golite062009
RNA binding	0.0261282189186349	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.88

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..297]	PSI-BLAST	110.0	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
2	View Details	[298..937]	PSI-BLAST	1000.0	Formyltetrahydrofolate synthetase

Protein Overview: SPBC839.16

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: